2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Circulation
JANUARY 27, 2025
Circulation, Ahead of Print.
Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours
The New England Journal of Medicine
APRIL 2, 2025
In patients with posterior circulation stroke for whom thrombectomy was not planned, alteplase administered 4.5 to 24 hours after stroke onset resulted in less disability at 90 days than standard treatment.
Circulation 
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Alteplase increases frequency of functional independence after posterior circulation stroke
Medical Xpress - Cardiology
APRIL 4, 2025
For patients with mainly mild posterior circulation ischemic stroke who do not receive thrombectomy, alteplase administered at 4.5
Circulation 52
52 
Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial
Circulation: Cardiovascular Interventions
MARCH 9, 2025
Circulation: Cardiovascular Interventions, Ahead of Print. No significant differences were observed in documented arrhythmias, bleeding, or stroke. Background:Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder (GSO), are used for transcatheter patent foramen ovale (PFO) closure.
Chest Pain 70
70 
Blood platelet score detects previously unmeasured risk of heart attack and stroke
Medical Xpress - Cardiology
AUGUST 20, 2024
Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels.
Heart attacks 102
102 
New mechanisms in the development of stroke discovered
Medical Xpress - Cardiology
JUNE 14, 2024
A group of researchers from the University of Tartu and international scientists discovered new mechanisms of how stroke occurs by studying changes in mouse and human cells.
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89 Abstract WP167: Posterior Circulation Stroke is Associated with Increased Risk of Misdiagnosis as Compared to Anterior Circulation Stroke in a Multistate Cohort
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP167-AWP167, February 1, 2025. Background:Small studies have found that patients presenting with posterior circulation ischemic strokes are more likely than patients with anterior circulation strokes to suffer a missed or delayed diagnosis in the ED.
Circulation 40
40 
O2 pulse slope correlates with stroke volume during exercise in patients with a Fontan circulation
Open Heart
NOVEMBER 7, 2023
Background Peak oxygen pulse (O 2 pulse=oxygen consumption/heart rate) is calculated by the product of stroke volume (SV) and oxygen extraction. It has been shown to be reduced in patients with a Fontan circulation. However, in the Fontan population, it may be a poor marker of SV.
Exercise 52
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Early Neurologic Deterioration and Efficacy of Dual Antiplatelet in Anterior Versus Posterior Circulation Stroke
Journal of the American Heart Association
JANUARY 23, 2025
BackgroundAnterior circulation stroke (ACS) differs from posterior circulation stroke (PCS) in several aspects. Primary outcome was occurrence of END at 7 days, defined as 2point increase in National Institutes of Health Stroke Scale score compared with baseline. Median age was 66 years and 35.1% were women.
Circulation 40
40 
Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories
DAIC
JUNE 18, 2024
A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. This includes a doubling of stroke rates. population.
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105 Atherogenic circulating lipoproteins in ischemic stroke
Frontiers in Cardiovascular Medicine
DECEMBER 5, 2024
However, the corresponding studies are scarcer in the field of ischemic stroke, despite carotid arteriosclerosis progression underlies at least 20% of ischemic strokes. The present review relates qualitative alterations of LDL and HDL with the development of carotid arteriosclerosis and the occurrence of ischemic stroke.
Circulation 40
40 
Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques
Frontiers in Cardiovascular Medicine
APRIL 24, 2024
The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. EVs were isolated from serum by precipitation.
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Abstract TMP82: First line aspiration versus stent retriever for posterior circulation stroke; A meta-analysis
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATMP82-ATMP82, February 1, 2025. Introduction:Aspiration and stent retriever thrombectomy are the primary approaches for endovascular management of posterior circulation stroke. However, the optimal first-line choice of surgical technique remains unclear.
Stent 40
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American Heart Month Puts Spotlight on Cardiovascular Disease and Stroke Statistics
DAIC
FEBRUARY 1, 2024
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4
Abstract WMP120: Circulating Mucosal-Associated Invariant T Cells Are Associated with Acute Human Ischemic Stroke and Predict Poor Outcome
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP120-AWMP120, February 1, 2025. Introduction:We previously demonstrated that Mucosal-associated Invariant T (MAIT) cells were involved in acute ischemic stroke by regulating neuroinflammation (JAHA 2021). 0.15), 0.31% (0.15-0.79), 0.79), 0.31% (0.19-0.80); 0.80); p <0.0001] (Figure 1A).
Circulation 40
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Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association
Circulation
JUNE 4, 2024
Circulation, Ahead of Print. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. to 3.8%), stroke (3.9% in 2020 to 61.0% The prevalences of poor diet, inadequate physical activity, and smoking are estimated to improve over time, whereas inadequate sleep will worsen.
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Abstract WP354: Neuroinflammatory Factor Response in Acute Ischemic Stroke Correlates with Lesion Volume and Stroke Severity: Circulating Blood from a Mobile Stroke Unit and during Hospitalization
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP354-AWP354, February 1, 2025. Background:Circulating neuroinflammatory factors change rapidly in acute stroke, but the association with ischemic lesion size and stroke severity is unknown. Twenty-six (57%) MSU patients were confirmed ischemic stroke (AIS). range 0-171) mL.
Strokes 40
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2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Circulation
JANUARY 24, 2024
Circulation, Ahead of Print.
Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association
Circulation
JUNE 4, 2024
Circulation, Ahead of Print. Stroke is projected to account for the largest absolute increase in costs. For cardiovascular conditions, annual health care costs are projected to almost quadruple, from $393 billion to $1490 billion, and productivity losses are projected to increase by 54%, from $234 billion to $361 billion.
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183?291 Participants From 29 Prospective Studies
Stroke Journal
DECEMBER 21, 2023
Stroke, Volume 55, Issue 1 , Page 50-58, January 1, 2024. BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts.
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Link between high levels of niacin -- a common b vitamin -- and heart disease, study suggests
Science Daily - Heart Disease
FEBRUARY 19, 2024
Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease.
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Abstract WP88: Association of renal biomarkers with fast progressor phenotype and related outcomes in anterior circulation large vessel occlusion stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).
Biomarkers 40
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You Have High Cholesterol & Don't Know What To Do About It.
Dr. Paddy Barrett
FEBRUARY 1, 2025
The Consequences of High Cholesterol Why high cholesterol is more than just a number—it’s a major risk factor for heart disease and stroke. 1 American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Committee. Circulation. 2025 Jan 27.
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Abstract TP307: Circulating immune cell landscape in ischemic stroke patients with early neurological deterioration
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP307-ATP307, February 1, 2025. Results:A total of 20 peripheral blood PBMC samples were collected from patients with acute ischemic stroke before and after the occurrence of END.
Circulation 40
40 
Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies
Heart BMJ
SEPTEMBER 25, 2024
We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD.
Circulation 52
52 
The $400B burden of heart disease, stroke: 15 notes
Becker's Hospital Review - Cardiology
JANUARY 28, 2025
Heart disease and stroke remained the leading causes of death in the U.S. in 2022, outpacing the number of combined deaths from cancer and accidental deaths, according to the American Heart Associations 2025 Heart Disease and Stroke Statistics report, published Jan. 27 in Circulation.
Abstract 13: Intravenous Tirofiban as An Adjunct to Endovascular Therapy for Posterior Circulation Strokes with Tandem Lesions: One-Year Outcomes
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. We included patients with acute ischemic stroke due to PCTLs who were treated with EVT. The patients were divided into two groups based on whether they received adjunctive intravenous Tirofiban therapy or not. 4.03], P=0.19). 0.59], P=0.001).Conclusion:Intravenous
Circulation 40
40 
Predictors of atrial fibrillation detection in embolic stroke of undetermined source patients with implantable loop recorder
Frontiers in Cardiovascular Medicine
MARCH 3, 2024
Background Covert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Conclusion Our study showed that posterior circulation infarcts with brainstem/cerebellum involvement are associated with AF detection in ESUS patients undergoing ILR.
Trial Results: Low-Dose Colchicine HelpsTreat Cardiovascular Disease
DAIC
MARCH 31, 2025
mg tablet), ananti-inflammatory atheroprotective cardiovascular treatment, to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established atherosclerotic disease or with multiple risk factors for cardiovascular disease. mg on atherosclerotic plaque.
Young adults with migraine, other nontraditional risk factors may have higher stroke risk
Medical Xpress - Cardiology
MARCH 26, 2024
Adults younger than 35 to 45 years old may have a higher risk of developing a stroke from nontraditional risk factors such as migraines than from traditional risks like high blood pressure. That's according to new research published today in Circulation: Cardiovascular Quality and Outcomes.
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Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3‐Butanediol in Patients With Heart Failure With Reduced Ejection Fraction
Journal of the American Heart Association
DECEMBER 24, 2024
Secondary end points were stroke volume, heart rate, left ventricular ejection fraction, circulating 3hydroxybutyrate, and free fatty acids. BD treatment provided significant increase in circulating 3hydroxybutyrate by 1400 mol/L (95% CI, 12621538 mol/L,P<0.001) and increased cardiac output by 0.9 L/min (95% CI, 0.71.1
Abstract 70: Machine Learning for Identification of Fast Progressors of Acute Anterior Circulation Ischemic Strokes in the Early Window Without CT Perfusion
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A70-A70, February 1, 2025. Purpose:Fast progressors (FP) of infarct growth in anterior circulation occlusions at 0-6 hours from onset (early window) have been associated with reduced rates of favorable outcome post endovascular thrombectomy (EVT).
Circulation 40
40 
Transcatheter PFO closure for cryptogenic stroke: current approaches and future considerations
Frontiers in Cardiovascular Medicine
MAY 19, 2024
Although generally considered a benign anatomic variant, a PFO may facilitate passage of a thrombus from the venous to arterial circulation, thereby resulting in cryptogenic stroke or systemic embolization.
Strokes 52
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Abstract WP306: Exploring the Cardiovascular Effect and Downstream Proteomic Signature of Pharmacologic Targeting of Circulating Adiponectin Levels in a Drug-Target Mendelian Randomization Framework
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP306-AWP306, February 1, 2025. variants in the vicinity (300 kb) of theADIPOQgene from a GWAS of circulating adiponectin levels (n=~38,600). 0.98; p=0.006) risk, but not ischemic stroke/subtypes (all p-values > 0.05). We selected genome-wide, independent (r2<0.1)
Pharmacology 40
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Abstract 4141868: Circulating immune cells, inflammatory risk, and atherosclerotic cardiovascular disease: an analysis across 5 cohorts of 17,971 diverse adults
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4141868-A4141868, November 12, 2024. Inflammatory responses result from coordinated actions of circulating molecular mediators and circulating immune cells (CIC). Introduction:Inflammation is pivotal in initiating and accelerating atherosclerotic cardiovascular disease (ASCVD).
Circulation 40
40 Acute Infarct Core Volume Estimation on Noncontrast Computed Tomography With a Deep Learning Algorithm
Stroke: Vascular and Interventional Neurology
DECEMBER 19, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDA simplified patient selection paradigm with noncontrast computed tomography (NCCT) can reduce the time to reperfusion and widen the eligibility of acute ischemic stroke large vessel occlusions (LVOs) for endovascular therapy. on the internal validation set.
Thrombolysis 75
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Impact of Diabetes on Outcomes in Left Main Coronary Revascularization: PCI vs. CABG
Cardiology Update
MARCH 25, 2024
In a recent study published in Circulation , examined how diabetes influences outcomes in left main coronary revascularization procedures, specifically PCI versus CABG, is crucial for tailored treatment strategies. Circulation. Original article: Gaba P et al. 2024;149:00–00.
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Immunothrombosis in Acute Ischemic Stroke
Stroke Journal
OCTOBER 31, 2024
Stroke, Ahead of Print. Ischemic stroke is one of the leading causes of disability and mortality worldwide. Thrombosis is the main pathological process of stroke and is therefore an important therapeutic target in stroke prevention.
Strokes 40
40 Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial
Stroke Journal
FEBRUARY 27, 2025
Stroke, Ahead of Print. BACKGROUND:Endovascular therapy (EVT) has been proven effective for patients with acute ischemic stroke with large infarcts. RESULTS:Among 455 eligible patients, 347 (76.3%) presented with moderate stroke (170 received EVT, 177 underwent MM), and 108 (23.7%) had severe stroke (60 received EVT, 48 underwent MM).
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CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association
Circulation
JUNE 20, 2024
Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke.
Salt Subs in Normal BP; Stroke Thrombectomy Without $$; Walmart's CVD Blood Test
Med Page Today
FEBRUARY 13, 2024
Circulation) Fewer than half of Americans know their blood pressure. (MedPage Today) -- Among commonly used glucose-lowering medications for type 2 diabetes, liraglutide (Victoza) was tied to a particularly robust reduction of cardiovascular events.
Thrombectomy for Stroke With Large Infarct on Noncontrast CT
American College of Cardiology
SEPTEMBER 24, 2024
Is thrombectomy superior to medical management alone in patients with anterior circulation large vessel occlusion (LVO) and large infarct on noncontrast head computed tomography (NCHCT) only who can be treated within 24 hours of last known normal?
Strokes 56
56 
Primary care professionals key to helping people achieve and maintain heart health, say researchers
Medical Xpress - Cardiology
NOVEMBER 13, 2024
Primary care clinicians and practices are uniquely positioned to help people achieve optimal cardiovascular health through screening, diagnosing and treating the health behaviors and factors outlined in the American Heart Association's Life's Essential 8 health metrics to reduce the risk for heart disease and stroke, according to a new scientific statement (..)
Research 74
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Philips Launches New Azurion Neuro Biplane System at #ECR2024 to Speed Up and Improve Minimally Invasive Diagnosis and Treatment of Neurovascular Patients
DAIC
FEBRUARY 28, 2024
Minimally invasive procedures are a key part of the diagnosis and treatment pathway for stroke , where every minute counts in conserving the patient’s quality-of-life. Together, I am confident we can continue to reduce the impact of stroke, helping more patients to recover faster and reducing long-term impact on their health.”
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