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Medtronic Announces FDA Approval of Newest-generation Evolut TAVR System for Treatment of Symptomatic Severe Aortic Stenosis

DAIC

milla1cf Thu, 03/28/2024 - 07:30 March 28, 2024 — Medtronic plc, a global leader in healthcare technology, announced that the United States Food and Drug Administration ( FDA ) has approved the Evolut FX+ transcatheter aortic valve replacement (TAVR) system for the treatment of symptomatic severe aortic stenosis. Aortic stenosis.

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Cerebral Hemodynamic Impairment and Cognitive Dysfunction in APOE4 Carriers With Asymptomatic Carotid Artery Stenosis/Occlusion

Journal of the American Heart Association

BackgroundOur previous preclinical study demonstrated thatAPOE4targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment thanAPOE3targeted replacement mice with carotid artery stenosis due to neurovascular dysfunction.

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Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques

Frontiers in Cardiovascular Medicine

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. EVs were isolated from serum by precipitation. EVs were isolated from serum by precipitation.

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Abstract 4120743: MEK inhibition for recurring pulmonary valve stenosis in RASopathy patients

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4120743-A4120743, November 12, 2024. However, the most recurrent cardiac complication in RASopathies is pulmonary valve stenosis (PVS). Backgound:The RASopathies are developmental syndromes resulting from variants in the RAS/mitogen-activated protein (MAPK) cascade.

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What Are the Implications of Choosing a TAVR-First Strategy in the Lifetime Management of Aortic Stenosis?: A Critical Review of TAVR-Explant- and Redo-TAVR

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print. Some patients with aortic stenosis may require multiple valve interventions in their lifetime, and choosing transcatheter aortic valve replacement (TAVR) as the initial intervention may be appealing to many.

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Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Patients with paradoxical low-flow, low-gradient severe aortic stenosis exhibit low transvalvular flow rate (Q), while maintaining preserved left ventricular ejection fraction. Subgroups were based on MR severity (severe and nonsevere).

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Abstract WP222: Basilar Artery Stenosis in Children With Moyamoya

Stroke Journal

Introduction:Moyamoya is a progressive cerebrovascular disease characterized by stenosis of the cerebral arteries in the anterior circulation and less often the posterior circulation. Children with moyamoya and basilar stenosis mentioned in their chart were initially included. In our cohort 7.2%