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Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preservedejectionfraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,
For patients with heart failure with preservedejectionfraction (HFpEF), endovascular treatment (EVT) improves left ventricular (LV) diastolic function, according to a study published online Sept. 9 in Circulation: Heart Failure.
Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023. BACKGROUND:Heart failure with preservedejectionfraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive.
Circulation: Heart Failure, Volume 16, Issue 11 , Page e010802, November 1, 2023. Heart failure with preservedejectionfraction (HFpEF) has become the leading form of heart failure worldwide, particularly among elderly patient populations.
Circulation, Ahead of Print. BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejectionfraction. Dapagliflozin did not improve these outcomes in patients with HF with preservedejectionfraction.
Circulation, Volume 150, Issue Suppl_1 , Page A4121812-A4121812, November 12, 2024. Background:Heart failure (HF) with preservedejectionfraction (HFpEF) is a complex syndrome characterized by heterogeneous pathophysiology and dynamic changes in cardiac structure and function.
Circulation, Volume 148, Issue 24 , Page 1945-1957, December 12, 2023. BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preservedejectionfraction.
Circulation, Volume 150, Issue Suppl_1 , Page A4118341-A4118341, November 12, 2024. As heart failure with preservedejectionfraction (HFpEF) comprises half of all heart failure cases, understanding its management and effect on outcomes is crucial.
Circulation, Ahead of Print. Background: Patients with heart failure, a preservedejectionfraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure.
Circulation: Heart Failure, Ahead of Print. Background:NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heart failure with preservedejectionfraction (HFpEF), even in the presence of increased left ventricular filling pressures.
Circulation, Volume 150, Issue Suppl_1 , Page A4120990-A4120990, November 12, 2024. Background:Recent advancements have seen deep learning models help differentiate echocardiography images of patients with heart failure with preservedejectionfraction (HFpEF) from normal controls.
Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preservedejectionfraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. In the STEP-HFpEF trial, once-weekly semaglutide 2.4
Circulation: Heart Failure, Ahead of Print. In heart failure with reduced ejectionfraction, exercise stimulates a reflex increase in muscle sympathetic nerve activity (MSNA) that relates inversely to peak oxygen uptake (VO2peak). BACKGROUND:In heart failure, sympathetic excess and exercise intolerance impair quality of life.
Circulation, Volume 151, Issue 2 , Page 149-158, January 14, 2025. BACKGROUND:Patients with heart failure (HF) with mildly reduced or preservedejectionfraction face heightened long-term risks of morbidity and mortality.
Circulation: Heart Failure, Volume 17, Issue 12 , Page e011629, December 1, 2024. Spironolactone reduced HF events in some patients with HF with preservedejectionfraction, but the results were not generalizable to all patients with HF with preservedejectionfraction.
Circulation, Volume 150, Issue Suppl_1 , Page A4143037-A4143037, November 12, 2024. The study therefore investigated the prognostic role of GLS in the elder patients with ADHF and preserved left ventricular ejectionfraction (LVEF).Methods:Patients,
Among patients with heart failure with preservedejectionfraction (HFpEF), right ventricular (RV) dysfunction is strongly associated with an increased risk of morbidity and mortality.
Circulation, Volume 150, Issue Suppl_1 , Page A4141446-A4141446, November 12, 2024. Emerging evidence suggests that vascular stress from cardiovascular-related co-morbidities promotes microvascular dysfunction, a key component in the development of heart failure with preservedejectionfraction.
Circulation: Heart Failure, Ahead of Print. We aimed to assess absolute coronary flow, absolute microvascular resistance, myocardial perfusion, coronary flow reserve, and microvascular resistance reserve in patients with HF with preservedejectionfraction and HF with reduced ejectionfraction (HFrEF).METHODS:Single-center,
Circulation: Heart Failure, Volume 16, Issue 12 , Page e010673, December 1, 2023. mm Hg in HF with preservedejectionfraction patients and was also exacerbated by exercise. BACKGROUND:Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. P<0.001).
Circulation: Heart Failure, Ahead of Print. The relationship between HR and risk was steeper in heart failure with reduced ejectionfraction versus heart failure with mildly reduced ejectionfraction/heart failure with preservedejectionfraction. 0.95); 60 to 69 bpm, 0.78 (0.63–0.97);
HFpEF, heart failure with preservedejectionfraction; HFrEF, heart failure with reduced ejectionfraction. Associations of colchicine-related plasma proteins, incident heart failure (HF) and cardiac structure and function.
Circulation, Ahead of Print. BACKGROUND:Heart failure with preservedejectionfraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining heart health by draining fluids and immune cells.
BackgroundThe purpose of this study was to investigate whether circulating pyruvate kinase M2 (PKM2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in patients with heart failure (HF).Methods Journal of the American Heart Association, Ahead of Print. versus 7.82.3 versus 16.73.6
Circulation, Ahead of Print. BACKGROUND:Metabolic distress is often associated with heart failure with preservedejectionfraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF.
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:In patients with heart failure with preservedejectionfraction (HFpEF), the impact of type 2 diabetes (T2D) on left ventricular global longitudinal strain (LV GLS) and its prognostic implications remains unclear.
Gorter TM, van Veldhuisen DJ, Bauersachs et al Right heart dysfunction and failure in heart failure with preservedejectionfraction: mechanisms and management. Fellows must be familiar with at-least half of them.( RIMP is less practical and error prone can be ignored) Reference 1. Eur J Heart Fail. 2018 Jan;20(1):16-37.
Circulation: Heart Failure, Ahead of Print. BACKGROUND:Older adults have markedly increased risks of heart failure (HF), specifically HF with preservedejectionfraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification.
Circulation, Volume 150, Issue Suppl_1 , Page A4147717-A4147717, November 12, 2024. We excluded articles related to acute decompensated HF and HF with preservedejectionfraction. The primary outcome was the change in NYHA functional class (FC).
Circulation, Volume 150, Issue Suppl_1 , Page A4146852-A4146852, November 12, 2024. The H2FPEF score and probability were developed to assist in heart failure with preservedejectionfraction (HFpEF) diagnosis. 2022 were included.
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