Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Together, these data demonstrate that the dynamics of FA flux through LD affects endothelial cell homeostasis and consequently large vessel function during normal physiology and in a chronic disease state.

Atherosclerosis 131

Atherosclerosis Chronic Disease Physiology Circulation 131

Journal of the American Heart Association

FEBRUARY 8, 2025

Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation.

Exercise 40

Exercise Pulmonary Hypertension Quality of Life 40

Physiologically Speaking

APRIL 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Prolonged sitting also leads to a bending of major arteries in our legs, leading to a blood flow pattern known as turbulent flow, blood pooling, impaired circulation, and endothelial dysfunction.

Blood Pressure 52

Blood Pressure Physiology Exercise Diet 52

Circulation: Cardiovascular Interventions

APRIL 14, 2025

Circulation: Cardiovascular Interventions, Volume 18, Issue 4 , Page e014919, April 1, 2025. BACKGROUND:Previous studies have shown weak agreement between coronary physiology indices derived from continuous and bolus thermodilution, and suggested greater variability with bolus thermodilution measurements. versus 0.70 versus 0.20

Physiology 40

Physiology Transplant Cardiovascular Interventions Circulation 40

Hypertension Journal

DECEMBER 3, 2024

BACKGROUND:Circulating proteins in blood are involved in various physiological processes, but their contributions to blood pressure regulation remain partially understood. Colocalization analyses were then used to investigate whether the circulating proteins and blood pressure traits shared causal genetic variants.

Blood Pressure 40

Blood Pressure Circulation Hypertension Physiology 40

Physiologically Speaking

FEBRUARY 16, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. There’s a long-running debate in exercise physiology about what limits VO2 max. Physiology is integrative, not isolated. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 52

Physiology Exercise Pulmonary Circulation 52

Circulation: Heart Failure

JANUARY 20, 2025

Circulation: Heart Failure, Ahead of Print. The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle.

Cardiogenic Shock 40

Cardiogenic Shock Heart Failure Circulation Physiology 40

Journal of the American Heart Association

MARCH 8, 2024

This approach allowed us to evaluate the effect of childhood body size on 11 measures of right heart and pulmonary circulation independent of other anthropometric traits at various stages in the lifecourse. 0.33];P=3×10−7) independent of adulthood body size.

Circulation 40

Circulation Pulmonary Physiology 40

Circulation

DECEMBER 7, 2023

Circulation, Ahead of Print. Resistance training not only can improve or maintain muscle mass and strength, but also has favorable physiological and clinical effects on cardiovascular disease and risk factors.

Cardiovascular Disease 85

Cardiovascular Disease Exercise Risk Factors Physiology 85

Circulation

FEBRUARY 5, 2024

Circulation, Ahead of Print. Because of the immature myocardium, the hemodynamic consequences of either bradyarrhythmias or tachyarrhythmias may be far more significant than in mature physiological states. Disorders of the cardiac rhythm may occur in both the fetus and neonate.

Pharmacology 78

Pharmacology Arrhythmia Physiology Circulation 78

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141415-A4141415, November 12, 2024. After significant workup and diagnostic testing, it was believed that he had late complications often seen in Fontan physiology, notably hepatic fibrosis, lymphatic leakage, and protein losing enteropathy.

Pacemaker 40

Pacemaker Physiology Stents Stent 40

Journal of the American Heart Association

JANUARY 9, 2024

The unique underlying anatomic and physiological background further adds to the difficulty in eliminating the AF burden in these patients. The increasing prevalence of atrial fibrillation (AF) in adults with congenital heart disease raises significant questions regarding its management.

Congenital Heart Disease 75

Congenital Heart Disease Congenital Atrial Fibrillation Heart Disease 75

Medical Xpress - Cardiology

JULY 2, 2024

Exercise testing can serve as a powerful physiologic probe to unmask subclinical cardiovascular abnormalities well before disease onset. At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk.

Hypertension 52

Hypertension Blood Pressure Exercise Physiology 52

Circulation: Cardiovascular Interventions

FEBRUARY 20, 2024

Circulation: Cardiovascular Interventions, Ahead of Print.

STEMI 40

STEMI Physiology Cardiovascular Interventions Circulation 40

Circulation: Cardiovascular Interventions

APRIL 17, 2024

Circulation: Cardiovascular Interventions, Ahead of Print.

Physiology 40

Physiology Cardiovascular Interventions Stenosis Aortic 40

Stroke Journal

FEBRUARY 1, 2024

Post-Fontan circulation may impact function in multiple organ systems, but its long term effects on the brain microvasculature are not well characterized. Exposure to Fontan circulation may be associated with early onset of cerebral SVD, suggesting increased long term risk of stroke and dementia.

Congenital Heart Disease 40

Congenital Heart Disease Congenital Heart Disease Physiology 40

Circulation

NOVEMBER 29, 2023

Circulation, Ahead of Print. To explore the physiological relevance of the model system studies, we isolated HDL from LCAT-deficient subjects, the small HDLs (eg, reconstituted HDLs) of which are discoidal and composed of apoA1, cholesterol, and phospholipid.

Cholesterol 75

Cholesterol Cardiovascular Disease Physiology Circulation 75

MIBHS

JANUARY 31, 2025

The Role of Wearable Technology in Heart Health Wearable tech is designed to monitor physiological data and provide actionable insights to users. Abnormal readings can signal issues with circulation or lung function, prompting further investigation. Sleep Monitoring Quality sleep is essential for heart health.

Heart Rhythm 52

Heart Rhythm Technology AFIB Exercise 52

DAIC

FEBRUARY 13, 2024

In contrast, macrophages derived from the recipient's circulation swiftly populated the heart shortly after transplantation. The research, led by esteemed physician-scientist at The Texas Heart Institute ( THI ), Dr. James F. Martin , Vivian L.

Transplant 111

Transplant Pediatrics Heart Transplant Research 111

Circulation

MARCH 28, 2024

Circulation, Ahead of Print. Wearable biosensors (wearables) enable continual, noninvasive physiologic and behavioral monitoring at home for those with pediatric or congenital heart disease. Wearables allow patients to access their personal data and monitor their health.

Congenital Heart Disease 45

Congenital Heart Disease Congenital Heart Disease Technology 45

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4119062-A4119062, November 12, 2024. Endothelial cell (EC) sensing of elevated fluid shear stress (FSS) from blood flow induces vessel outward remodeling to restore physiological FSS, but mechanisms are poorly understood.

Physiology 40

Physiology Ischemia Diabetes Circulation 40

Circulation: Arrhythmia and Electrophysiology

FEBRUARY 10, 2025

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. and 0.64, respectively) with similar phenotypes.CONCLUSIONS:Long-term and acute responses to AF ablation reflect distinct clinical and electrical physiology, respectively. The external validation cohort showed similar results (area under the curve=0.81

Atrial Fibrillation 40

Atrial Fibrillation Ablation Physiology Arrhythmia 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140803-A4140803, November 12, 2024. It was first described over 150 years ago, however the physiological mechanism and pathophysiological implications are not well understood. This study aimed to elucidate underlying mechanisms and physiological function of vasomotion in human arteries.

Physiology 40

Physiology Pacemaker Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144226-A4144226, November 12, 2024. Background and Objectives:Neonatal cardiac surgery requires careful consideration of cardiopulmonary bypass (CPB) priming fluid composition due to small blood volume and immature physiology.

Physiology 40

Physiology Circulation Outcomes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140767-A4140767, November 12, 2024. Physiological class (PC) was determined by clinicians according to the 2018 AHA/ACC guidelines. Feature-tracking of SSFP cine was retrospectively utilized to quantify radial, circumferential, and longitudinal strain in both 2 and 3 dimensions.

Outcomes 40

Outcomes Congenital Physiology Heart Failure 40

Circulation: Cardiovascular Interventions

APRIL 24, 2025

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Injection of contrast media for rapid measurement of contrast fractional flow reserve (cFFR) obviates the side effects and time requirements of adenosine fractional flow reserve (aFFR) and improves diagnostic performance relative to nonhyperemic pressure ratios.

Coronary Artery Disease 40

Coronary Artery Disease Cardiovascular Interventions Physiology Stenosis 40

Circulation: Cardiovascular Interventions

JANUARY 15, 2024

Circulation: Cardiovascular Interventions, Volume 17, Issue 1 , Page e013481, January 1, 2024. BACKGROUND:The underlying mechanisms responsible for the clinical benefits following coronary sinus narrowing and pressure elevation remain unclear. The primary outcome was the change in the values of the index of microcirculatory resistance.

Angina 40

Angina Coronary Artery Disease Physiology Cardiovascular Interventions 40

Dr. S. Venkatesan MD

JULY 1, 2024

An alternate hypothesis : Siphon effect in cranial circulation Some believe the heart is assisted by an alternate mechanism in the Giraffes. The hemodynamic of the Giraffe’s vascular system is a good physiologic model of circulation, that defy gravity. The carotid artery could act like a siphon from the heart.

Cardiomyopathy 52

Cardiomyopathy Aortic valve Aortic Blood Pressure 52

Circulation: Heart Failure

NOVEMBER 8, 2024

Circulation: Heart Failure, Volume 17, Issue 12 , Page e011725, December 1, 2024. For most women, this physiological adaptation resolves at the end of pregnancy, but some women develop pathological dilatation and ultimately heart failure late in pregnancy or in the postpartum period, manifesting as peripartum cardiomyopathy (PPCM).

Cardiomyopathy 40

Cardiomyopathy Heart Failure Physiology Circulation 40

Circulation

AUGUST 26, 2024

Circulation, Volume 151, Issue 1 , Page 59-75, January 7, 2025. In response to physiological changes, YAP moves in and out of the nucleus. BACKGROUND:The Hippo pathway effector YAP (Yes-associated protein) plays an essential role in cardiomyocyte proliferation and heart regeneration.

Myocardial Infarction 40

Myocardial Infarction Physiology Circulation 40

Dr. S. Venkatesan MD

MAY 26, 2024

LDL is potrayed as villian de-chief of atheroscerlois and CAD.But, LDL of about 100 to 160 mg concentration is in constant circulation, in a smooth manner serving other physiological vascular functions.

Pharmacology 45

Pharmacology Cholesterol Physiology Diabetes 45

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147397-A4147397, November 12, 2024. Frailty is a syndrome of physiological decline, characterized by marked vulnerability to adverse health outcomes. Background:Ischemic heart disease (IHD) is a prevalent cardiovascular disease (CVD) associated with high morbidity and mortality.

Heart Disease 40

Heart Disease Hospital Inpatient Outcomes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140645-A4140645, November 12, 2024. BACKGROUND:Electrical and dynamic stimulation are commonly used to enhance the maturation of engineered cardiac tissue (ECT) derived from induced pluripotent stem cells (iPSCs), reflecting the physiological environment of the heart.

Physiology 40

Physiology Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4123391-A4123391, November 12, 2024. However, surgery was deferred because of decompensated HFpEF, as evidenced by significant leg edema on exam, and severely elevated left and right-side filling pressure, with restrictive physiology on right heart catheterization.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Cardiomyopathy Heart Failure Pulmonary 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4115027-A4115027, November 12, 2024. Background:The emerging field of cardiac optogenetics uses pulses of light to stimulate optically-sensitive proteins in the heart, influencing cellular physiology with unprecedented spatiotemporal resolution.

Echocardiogram 40

Echocardiogram Bicuspid/Mitral Heart Rhythm Cardiac Function 40

Circulation

JANUARY 12, 2024

Circulation, Ahead of Print. BACKGROUND:Cardiac transverse tubules (T-tubules) are anchored to sarcomeric Z-discs by costameres to establish a regular spaced pattern. One of the major components of costameres is the dystrophin-glycoprotein complex (DGC).

Cardiomyopathy 45

Cardiomyopathy Physiology Circulation 45

Stroke: Vascular and Interventional Neurology

JUNE 20, 2024

The foods we eat, coupled with our physiology and exposures (eg, antibiotics, supplements), directly contribute to atherosclerotic disease in complex ways that are mediated by gastrointestinal flora and metabolic byproducts.

Cerebrovascular Disease 40

Cerebrovascular Disease Atherosclerosis Atrial Fibrillation Physiology 40