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Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease.
Furthermore, we utilized mass spectrometry analysis, network pharmacology, and lipidomics to predict the potential mechanisms of FFDS in the treatment of SCHD.ResultsFollowing treatment, FFDS demonstrated significant improvements in serum triglyceride levels (P=0.013) and a reduction in the frequency of angina episodes (P=0.021).
Circulation, Ahead of Print. This scientific statement discusses the mechanism of arrhythmias, pharmacological treatment options, and distinct aspects of pharmacokinetics for the fetus and neonate. Disorders of the cardiac rhythm may occur in both the fetus and neonate.
Temporal change in such biomarkers, particularly in response to pharmacological interventions and/or mechanical circulatory support, can guide management and predict outcome. It is believed that a self-propagating spiral of events follows as a result of hypoperfusion, ischaemia and inflammation, leading to end-organ dysfunction.
Here, we use large-scale omics data to explore whether pharmacologic targeting of the adiponectin pathway may contribute to lowering CVD risk.Methods:To proxy the effect of pharmacologically perturbing the adiponectin pathway we used a drug-target mendelian randomization (MR) approach. We selected genome-wide, independent (r2<0.1)
Circulation, Volume 151, Issue 6 , Page 400-415, February 11, 2025. Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures.
Objective In Fontan circulation, pulmonary arterial hypertension (PAH)-targeted therapies could improve the patients’ exercise capacity. Pharmacological improvement of submaximal exercise seems to be a more suitable indicator of Fontan individuals’ exercise capacity.
Abstract Aims Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.
Circulation, Ahead of Print. BACKGROUND:Genetic and experimental studies support a causal involvement of IL-6 (interleukin-6) signaling in atheroprogression. Although trials targeting IL-6 signaling are underway, any benefits must be balanced against an impaired host immune response.
Circulation, Volume 150, Issue Suppl_1 , Page A4146046-A4146046, November 12, 2024. However, there are currently no pharmacological treatments for CAVD, and the discovery of de novo molecules targeting a specific protein is a time-intensive and financially demanding process.
Circulation, Ahead of Print. The pharmacological effect of ME1* on PH treatment was evaluated in PH animal models induced by SuHx.RESULTS:We found that ME1 protein level and enzymatic activity were highly elevated in lung tissues of patients and mice with PH, primarily in vascular endothelial cells.
The supposition that beta blockade in the presence of cocaine intoxication would lead to unopposed alpha constriction is not based in accurate pharmacology, and the study that showed this effect with human intracoronary administration was done, as mentioned in the article, with propranolol, a nonselective beta blocker. Tadjziechy, M.
Heparin, the most utilized anticoagulant, carries concerns for heparin-induced thrombocytopenia and possible resistance given its dependence on co-factors and circulating proteins to exert its pharmacologic effect.
That’s the subject of a new study by a team that includes two USF Health doctors who reported their findings in Circulation , the flagship journal of the American Heart Association. “An The damage to the heart muscle is usually permanent, leaving the heart unable to pump the way it should.
Circulation, Volume 150, Issue Suppl_1 , Page A4137905-A4137905, November 12, 2024. Background:In out-of-hospital cardiac arrest (OHCA) patients with an initial shockable rhythm, epinephrine increases the likelihood of return of spontaneous circulation (ROSC), but its effect on neurological outcome remains uncertain.
This study aimed to identify proteomic expression patterns in large core infarct patients undergoing MT to inform potential pharmacological intervention targets.Methods:The Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) tissue registry was reviewed for anterior circulation MT patients treated between June 2017-December 2023.
Circulation, Volume 150, Issue Suppl_1 , Page A4117657-A4117657, November 12, 2024. Pharmacological inhibition of GPR39 may open new frontiers in the treatment of PAH. Background:Primary pulmonary arterial hypertension (PAH) is a disease affecting young subjects. It has very poor prognosis and optimal treatment is not available.
LDL is potrayed as villian de-chief of atheroscerlois and CAD.But, LDL of about 100 to 160 mg concentration is in constant circulation, in a smooth manner serving other physiological vascular functions. Francesca Luchetti , Rita Crinelli , Maria Gemma Nasoni , Serena Benedetti , Francesco Palma , Alessa British Journal of pharmacology.
Circulation, Volume 150, Issue Suppl_1 , Page A4145490-A4145490, November 12, 2024. Background:Cancer is well known to cause a pro-thrombotic state, however, the pharmacologic therapy for prevention of Venous Thromboembolism (VTE) remains under contention.
Circulation, Volume 150, Issue Suppl_1 , Page A4141474-A4141474, November 12, 2024. While it is known to increase serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unexplored.
Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Current treatments, predominantly pharmacological, target signaling pathways involved in fibroblast activation but often come with side effects such as cardiac toxicities.
This is known as the coronary collateral circulation. These tiny side roads and that network of tiny roads which ultimately get me to my destination are analogous to the Coronary collateral circulation. A lot of research has therefore focussed on methods by which we could improve our coronary collateral circulation.
Circulation, Ahead of Print. Pharmacological blockade of RAC1 by R-Ketorolac or NSC23766 may therefore represent a potential treatment against aortic aneurysm and dissection. BACKGROUND:S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease.
Circulation, Ahead of Print. Through various experimental techniques, such as gene manipulation, pharmacological inhibition, and proteolysis targeting chimera, this study demonstrated that mtDNA 6mA and its specific enzyme METTL4 hold potential as therapeutic targets for atherosclerosis.
Circulation, Volume 150, Issue Suppl_1 , Page A4142210-A4142210, November 12, 2024. Despite comprehensive anticoagulation protocols, discrepancies in pharmacologic responses due to patient-specific factors such as adherence to anticoagulation, renal function, and genetics suggest that imaging studies may still be critical for patient safety.
Edited by Bracey, Meyers, Grauer, and Smith A 50-something-year-old female with a history of an unknown personality disorder and alcohol use disorder arrived via EMS following cardiac arrest with return of spontaneous circulation. Circulation. The described rhythm was an irregular, wide complex rhythm. JAMA Intern Med. 2017.3191.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. The primary outcome was the percentage of patients receiving appropriate prophylaxis (high-risk patients with pharmacological thromboprophylaxis plus low-risk patients without prophylaxis) within 48 hours of hospitalization.
Circulation, Ahead of Print. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics. BACKGROUND:Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism.
New HCM Guidelines Updated recommendations in the guideline reflect recent evidence about HCM treatment and management including new forms of pharmacologic management; participation in vigorous recreational activities and competitive sports; and risk stratification for sudden cardiac death (SCD) with an emphasis on pediatric patients.
Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins. Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins.
Circulating melatonin levels were significantly decreased in DCM mice and were associated with LVEF. Circulating melatonin levels were significantly decreased in DCM mice and were associated with LVEF. M2-type macrophages were analyzed by flow cytometry. M2-type macrophages were analyzed by flow cytometry.
Carbone: A study recently published in the Journal of the American College of Cardiology looked at the effect of physical activity and sedentary behaviors in a very large number of patients,13 and we have reviewed this topic in a recent review published on Circulation Research. [14] Circulation Research 118.11 (2016): 1752-1770.
Author continued: Another positive inotrope to consider would be milrinone as it decreases SVR and increases cardiac output; however, one must proceed with caution as the pharmacological mechanism of milrinone can cause vasodilation and worsen hypotension. Circulation. Circulation 67, No. Circulation 1970;41:623-627 9.
mEq of K pushed fast and circulated theoretically would raise serum K immediately by 1.0 Crit Care Med 1991; 19:694) Concentrated Potassium Chloride Infusions in Critically Ill Patients with Hypokalemia The Journal of Clinical Pharmacology. Since it takes some time (how long?) mEq/L, and 10 mEq would increase it by 3.3 mEq/L, from 1.9
Maeda’s award-winning presentation, Abstract 15, “Pharmacological Activation of Efferocytosis Prevents Intracranial Aneurysm Rupture,” was presented in a morning session Feb. Raed Joundi, M.D., is the Vascular Cognitive Impairment Award recipient. The Siekert New Investigator Award in Stroke recognizes Robert G. Siekert, M.D.,
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