Circulation, Pediatrics and Transplant

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

DAIC

FEBRUARY 13, 2024

© THE TEXAS HEART INSTITUTE 2024 milla1cf Tue, 02/13/2024 - 17:56 February 13, 2024 — Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. This helps us gain a comprehensive understanding of the immune response dynamics within transplanted hearts."

Transplant

Transplant Pediatrics Heart Transplant Research

The Future of Pediatric and Adult Heart Transplantation: Perspective From the United States

Circulation

JANUARY 28, 2024

Circulation, Volume 149, Issue 5 , Page 339-341, January 30, 2024.

Heart Transplant

Heart Transplant Transplant Pediatrics Circulation

Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association

Circulation

MARCH 11, 2024

Circulation, Ahead of Print. Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. In pediatric patients, left ventricular systolic dysfunction and pericardial effusion are the most common cardiovascular complications.

Transplant

Transplant Cardiovascular Disease Atrial Fibrillation Pediatrics

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation

Circulation: Genomic and Precision Medicine

SEPTEMBER 28, 2023

Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 452-461, October 1, 2023. Background:Many cardiovascular disorders propel the development of advanced heart failure that necessitates cardiac transplantation. of patients with unexplained end-stage cardiomyopathy.

Heart Transplant

Heart Transplant Transplant Cardiomyopathy Pediatrics

Abstract 4134590: Procedural Related Major Adverse Events of Cardiac Catheterization in Pediatric Patients with Cardiomyopathy: Insights from IMPACT Registry

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4134590-A4134590, November 12, 2024. The association between a lower rate of MAE and EMB persisted in the multivariate model when those with heart transplant who had EMB were compared to those without heart transplant who did not have EMB p=0.001.

Cardiomyopathy

Cardiomyopathy Pediatrics Heart Transplant Heart Failure

The Macrophage Landscape Across the Lifespan of a Human Cardiac Allograft

Circulation

FEBRUARY 12, 2024

Circulation, Ahead of Print. BACKGROUND:Much of our knowledge of organ rejection after transplantation is derived from rodent models.METHODS:We used single-nucleus RNA sequencing to investigate the inflammatory myocardial microenvironment in human pediatric cardiac allografts at different stages after transplantation.

Transplant

Transplant Pediatrics Circulation

Abstract 4146466: Targeting Gut Microbiota-Derived Kynurenine to Predict and Protect the Remodeling of the Pressure Overloaded Young Heart

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146466-A4146466, November 12, 2024. Background:Without timely intervention, pressure-overloading left ventricular (poLV) remodeling may become progressive and readily degenerate into heart failure.

Congenital Heart Disease

Congenital Heart Disease Heart Failure Pediatrics Transplant

Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study

Circulation: Arrhythmia and Electrophysiology

FEBRUARY 12, 2024

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. The transplant-free survival rates at 3, 5, and 8 years after CRT implantation were 85%, 79%, and 73%.CONCLUSIONS:In Although cardiac resynchronization therapy (CRT) is an established treatment option, the effect of CRT in this population is still not well defined.

Congenital Heart Disease

Congenital Heart Disease Outcomes Electrophysiology Congenital

Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy

Circulation

JANUARY 9, 2025

Circulation, Ahead of Print. BACKGROUND:The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation (HT) in 2016 for pediatric patients and 2018 for adult patients.

Congenital Heart Disease

Congenital Heart Disease Pediatrics Cardiomyopathy Transplant

Abstract 4144326: Mid-Term Outcomes of Surgical Resection of Pediatric Cardiac Fibroma and Modified Ventricular Reconstruction Procedure

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144326-A4144326, November 12, 2024. It has changed the fate of young patients with large tumors who would have otherwise needed heart transplants, offering high suture strength and reducing postoperative complications. During a median follow-up period of 17.4

Pediatrics

Pediatrics Outcomes Heart Transplant Aneurysm

FDA Announces Abbott Recall of HeartMate 3 Left Ventricular Assist System (LVAS) Implant Kit

DAIC

MAY 15, 2024

The HeartMate 3 is used for both short- and long-term support in pediatric and adult patients with severe left ventricular heart failure. It can be used while waiting for a heart transplant, to help the heart recover, or as a permanent solution when a transplant isn't an option.

Transplant

Transplant Heart Failure Heart Transplant Pediatrics

Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension

Circulation: Cardiovascular Imaging

DECEMBER 16, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 12 , Page e016882, December 1, 2024. CONCLUSIONS:In the pediatric population, baseline PVRi and echo-estimated PASP were strongly associated with adverse clinical outcomes, but TAPSE and RVFW-LS were not.

Pediatrics

Pediatrics Pulmonary Congenital Heart Disease Hypertension

FDA Announces Recalls of Abbott/Thoratec Corp. Heartmate II and Heartmate 3 Left Ventricular Assist System (LVAS) Due to Long-term Buildup of biological material Causing an Obstruction

DAIC

APRIL 15, 2024

It can be used while waiting for a heart transplant, to help the heart recover, or as a permanent solution when a transplant isn't an option. HeartMate 3 can also be used in pediatric patients. The HeartMate II and 3 are used for both short- and long-term support in adult patients with severe left ventricular heart failure.

Transplant

Transplant Heart Transplant Pediatrics Heart Failure

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Part 1: Concepts, Indicator Variables, and Controversies The Annals of Thoracic Surgery January 2022 Arman Kilic Supplementing Existing Societal Risk Models for Surgical Aortic Valve Replacement With Machine Learning for Improved Prediction Journal of the American Heart Association November 2021 Jared Belle Strategies for Mechanical Right Ventricular (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Institutional Coronary Artery Bypass Case Volumes and Outcomes European Journal of Heart Failure October 2023 Makoto Mori 1 Robotic Mitral Valve Repair for Degenerative Mitral Regurgitation The Annals of Thoracic Surgery August 2023 Carlos Diaz-Castrillion 2 Volume-Failure to Rescue Relationship in Acute Type A Aortic Dissections: An Analysis of The (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

OMI in a pediatric patient? Teenagers do get acute coronary occlusion, so don't automatically dismiss the idea.

Dr. Smith's ECG Blog

DECEMBER 5, 2023

Acute coronary syndrome in a pediatric patient? An ECG was perfomed on arrival to our ED: NSR with ST elevation II,III, aVF with reciprocal depression in aVL Would you refer this pediatric patient for emergent PCI? Circulation. Circulation. Erratum in: Circulation. World J Pediatr. doi: 10.1161/CIR.0000000000001001.

Pediatrics

Pediatrics Pericarditis COVID-19 Congenital Heart Disease

Cardiovascular Update

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

The Future of Pediatric and Adult Heart Transplantation: Perspective From the United States

Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association

Webinars

Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation

Abstract 4134590: Procedural Related Major Adverse Events of Cardiac Catheterization in Pediatric Patients with Cardiomyopathy: Insights from IMPACT Registry

The Macrophage Landscape Across the Lifespan of a Human Cardiac Allograft

Abstract 4146466: Targeting Gut Microbiota-Derived Kynurenine to Predict and Protect the Remodeling of the Pressure Overloaded Young Heart

Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study

Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy

Abstract 4144326: Mid-Term Outcomes of Surgical Resection of Pediatric Cardiac Fibroma and Modified Ventricular Reconstruction Procedure

FDA Announces Abbott Recall of HeartMate 3 Left Ventricular Assist System (LVAS) Implant Kit

Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension

FDA Announces Recalls of Abbott/Thoratec Corp. Heartmate II and Heartmate 3 Left Ventricular Assist System (LVAS) Due to Long-term Buildup of biological material Causing an Obstruction

Published Research

Published Research

OMI in a pediatric patient? Teenagers do get acute coronary occlusion, so don't automatically dismiss the idea.

Stay Connected