Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionIntracranial atherosclerotic disease (ICAD) is associated with up to 32% of posterior circulation strokes.1 Rescue treatment with stenting, balloon angioplasty, and/or intraarterial thrombolysis or antiplatelets are often required to treat the underlying stenosis.

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Stent Stents Circulation Stroke 40

Stroke Journal

JANUARY 30, 2024

However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier. In this context, the impact of endogenous parenchymal tPA is limited.

Circulation 40

Circulation Stroke Strokes Embolism 40

Circulation: Cardiovascular Interventions

FEBRUARY 27, 2024

Circulation: Cardiovascular Interventions, Ahead of Print. Background:The role of advanced therapies (systemic thrombolysis, catheter-based treatment, and surgical thrombectomy) for the management of right heart thrombus is poorly defined. 1.22]), in-hospital mortality (odds ratio, 0.64 [95% CI, 0.17–2.19]),

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Outcomes Thrombolysis Embolism Pulmonary 40

Stroke: Vascular and Interventional Neurology

JANUARY 31, 2024

The primary outcome was routine discharge (home or self‐care). Secondary outcomes were in‐hospital mortality, intracerebral hemorrhage, and length of stay. In multivariable models, intravenous thrombolysis was independently associated with higher odds of routine discharge (adjusted OR, 1.78; 95% CI, 1.57–2.01;P<0.001)

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Inpatient Circulation Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Recent randomized control trials suggested that mechanical thrombectomy (MT) was associated with good functional outcomes after acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in patients presenting with low Alberta Stroke Program Early CT Score (ASPECTS) (defined as ASPECTS 2-5). with a score of 2, 17.7%

Stroke 40

Stroke Strokes Circulation Outcomes 40

Dr. S. Venkatesan MD

SEPTEMBER 1, 2024

In this context, we need a movement to revive the pre-hospital thrombolysis. best, It has a miniscule 1 % edge in the outcome if performed on time, at a expertise intensive place. Efficiency of thrombolysis is highly reproducible. Circulation 2005;111:761-7. Circulation 2006;114:2019-25

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Thrombolysis Myocardial Infarction Academic STEMI 52

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

Trichosanthes pericarpium is a well-known Chinese traditional herb described with the effect of activating blood circulation to dissipate blood stasis and improve blood circulation. However, its effects on microcirculation in patients with AMI after primary PCI remain unknown.

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Myocardial Infarction Cardiac Function Outcomes Thrombolysis 59

Stroke Journal

FEBRUARY 1, 2024

Introduction:Despite comparable outcomes for different frontline techniques in mechanical thrombectomy (MT) for acute ischemic stroke (AIS), there are sparse data regarding if and when to switch techniques if the first pass is unsuccessful. 3.86, P = 0.002) and 90-day good clinical outcome (adjusted odds ratio 2.10, 95% CI: 1.15-3.85,

Circulation 40

Circulation Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

We aimed to examine the impact of dexmedetomidine on outcomes in patients with anterior circulation large vessel occlusion (acLVO) requiring neurocritical care after endovascular therapy (EVT).Methods:We While favorable functional outcome was less frequently observed in the dexmedetomidine than in the comparator group (7.9%

Stroke 40

Stroke Strokes Outcomes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Up to 50% of acute ischemic stroke (AIS) patients who undergo successful mechanical thrombectomy (MT) fail to achieve favorable outcomes (futile recanalization). Stroke, Volume 55, Issue Suppl_1 , Page AWP180-AWP180, February 1, 2024. FR was defined as successful recanalization with 90-day modified Rankin Scale (mRS) 3-6.

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Circulation Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Overall, one in six individuals treated has improved neurologic and functional outcomes. Therefore, a reperfusion score of mTICI 2b may not be sufficient to indicate a high probability of a good functional outcome. No difference in the rate of intracerebral hemorrhage (ICH) following reperfusion between the TICI 2 and 3 groups (17%).Conclusion:Our

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40

Circulation

OCTOBER 19, 2023

Circulation, Ahead of Print. Study end points included timeliness of intravenous thrombolysis and EVT, successful reperfusion, discharge destination, discharge mortality, and functional independence at discharge.RESULTS:Among 84 903 patients, 48 682 received EVT, of whom 73% were treated at CSCs, 22% at PSCs, and 4% at TSCs.

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Stroke Strokes Thrombolysis Certification 40

Stroke Journal

FEBRUARY 1, 2024

Here, we investigate the association of middle cerebral artery(MCA) tortuosity on radiographic and functional outcome.Methods:The Analysis of Revascularization in Ischemic Stroke with EmboTrap II was utilized to identify patients with anterior circulation stroke. Good functional outcomes was defined as mRS0-2 on 90-day followup.

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Atrial Fibrillation Thrombolysis Ischemia Stroke 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 28, 2023

We aimed to determine if there were outcome differences in patients transferred for EVT via HEMS.MethodsA retrospective observational study was performed in the setting of a large regional network with 1 CSC receiving patients directly, or via road ambulance from 3 metropolitan PSCs or HEMS from 13 more distant PSCs.

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Thrombolysis Stroke Strokes Circulation 40

Circulation

OCTOBER 18, 2023

Circulation, Volume 148, Issue 24 , Page 1919-1928, December 12, 2023. The primary efficacy outcome was a composite of acute limb ischemia, major amputation of a vascular pathogenesis, myocardial infarction, ischemic stroke, or cardiovascular death. mg of rivaroxaban BID or matching placebo and 100 mg of aspirin daily.

Peripheral Arterial Disease 40

Peripheral Arterial Disease Myocardial Infarction Thrombolysis Ischemia 40

Stroke: Vascular and Interventional Neurology

DECEMBER 19, 2023

Primary outcome was 90‐day utility‐weighted modified Rankin scale. Secondary outcomes also favored MSU: early neurologic recovery (30% improvement in National Institutes of Health Stroke Scale score at 24 hours) 68% versus 52%; adjusted odds ratio 1.98 [95% CI, 1.19–3.33]; in MSU group and 0.51±0.41 4.77],P= 0.002). minutes [50.5–92.0]

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

A failed MT was defined as a modified Thrombolysis in Cerebral Infarction (mTICI) score of 0 to 2a after multiple attempts to clot retrieval. The primary efficacy outcome was the shift in the degree of disability, as measured by the modified Rankin Scale (mRS), at 90 days. MM: 49.7%, aOR=0.49, 95% CI 0.33‐0.74, 0.74, p=<0.001).ConclusionRS

Stents 40

Stents Stent Angioplasty Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 28, 2023

BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. Stroke: Vascular and Interventional Neurology, Ahead of Print. female).

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Stroke Strokes Thrombolysis Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Atrial fibrillation (AF) has been shown to be associated with better procedural outcomes in patients with anterior circulation large vessel occlusion (aLVO) undergoing endovascular therapy (EVT). Forty-four percent of the no AC group received intravenous thrombolysis (IVT). In the NOAC group, 59.5%

Atrial Fibrillation 40

Atrial Fibrillation Outcomes Thrombolysis Hemorrhage 40

Dr. Smith's ECG Blog

MARCH 11, 2016

Circulation 1993; 88:896-904. Patients who received CPR or experienced reinfarction or very small infarcts due to thrombolysis also displayed Type II T-wave evolution. Circulation 1995; 91:1659-1668. Circulation 1999; 74:1379-1389. A cutoff of 9 mm for inferior AMI and 13 mm for anterior AMI predicted worse outcome.

Myocardial Infarction 52

Myocardial Infarction Pericarditis Angina STEMI 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionCurrent evidence supports endovascular therapy (EVT) for eligible patients with acute ischemic stroke in the anterior and posterior circulation. 1.56, P= 0.28; I2 = 26%, Figure A) and the results of the anterior circulation subgroup showed non‐statistically significant difference (OR = 1.22, 95% CI: 0.90–1.67,

Stroke 40

Stroke Strokes Circulation Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionChoice of anesthesia for endovascular thrombectomy in large vessel occlusion of the anterior circulation has been well studied, although practice patterns may still be variable. After adjusting for age, sex, IV thrombolysis, and admission NIHSS, CS usage did not result in an increase in procedural time (β=1.3,

Thrombolysis 40

Thrombolysis Circulation Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

With the evolving technology and newer generation of catheters and devices, the interest in improving the technical and procedural factors that can help better the recanalization success, clinical outcomes, and efficiency is ever‐growing. Most of the patients had MCA occlusion (68.4% with 50.9% of cases.

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Thrombolysis Ischemia Hemorrhage Stroke 40

Dr. Smith's ECG Blog

AUGUST 3, 2017

Circulation. These patients had worse outcomes than patients with ST depression without occlusion; half of these were circumflex. O'Gara et al. There are several studies that indirectly reveal the proportion of STEMIs that are isolated to the posterior wall, and they range from 3% to 11%. (1, J Am Coll Card 1999;34(3):748-53.

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Chest Pain Myocardial Infarction STEMI Ischemia 52

DAIC

JANUARY 22, 2024

Best Medical Therapy in Acute Ischemic Stroke due to Large VEssel OcclusioN Trial in the Extended Time Window: Raul Nogueira, University of Pittsburgh, Pittsburgh, PA MOST Multi-Arm Optimization of Stroke Thrombolysis Trial: Opeolu Adeoye, Washington University, Saint Louis, MO Thurs.,

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Stroke Strokes Hospital Thrombolysis 100