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BackgroundPostoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. While hypoglycemia and hyperglycemia are known risk factors for adverse outcomes, the optimal glycemic range for patients undergoing ECC remains unclear.
Background We evaluated the potential of circulating bone morphogenetic protein 10 (BMP10) as a biomarker for atrial stress and remodelling in patients with heart failure (HF), in comparison to N-terminal pro-B-type natriuretic peptide (NT-proBNP). We also assessed the predictive value of BMP10 for adverse clinical outcomes.
Circulation, Ahead of Print. Outcomes included adverse pregnancy outcomes associated with increased risk of cardiovascular disease and the American Heart Associations Lifes Essential 8 health factor components (blood pressure, lipids, glucose, and gestational weight gain).
highlight the increasing prevalence of pregnancies among patients with Fontan circulation, a population characterized by significant obstetric risk. The findings of a 2023 analysis by Sobhani et al. The physiological demands of pregnancy exacerbate the unique hemodynamic challenges inherent to Fontan physiology.
Circulation, Ahead of Print. However, significant gaps exist in palliative care research related to nonheart failure populations, care partner outcomes, and palliative care implementation in diverse populations. Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements.
Circulation, Ahead of Print. The digital determinants of health include the impact of digital technologies (eg, wearables, telemedicine) across health outcomes. The digital determinants of health are important adjuncts to the social determinants and operate at the individual, interpersonal, community, and societal levels.
A new observational study suggests the position in which responders initially place the two defibrillator pads on the body may make a significant difference in returning spontaneous blood circulation after shock from a defibrillator.
Circulation: Cardiovascular Interventions, Ahead of Print. However, the impact of nickel hypersensitivity on post-procedural outcomes remains poorly understood. These findings highlight the need for further research to optimize device selection and improve outcomes in nickel-hypersensitive patients.
Circulation, Volume 151, Issue 15 , Page 1111-1125, April 15, 2025. Although traditional therapeutic strategies have focused on reducing the risk for hospitalization and mortality, the importance of patient-reported outcomes (PROs) in patients with heart failure is increasingly being recognized.
Abstract Cardiogenic shock (CS) carries a 3050% in-hospital mortality rate, with little improvement in outcomes in the last decade. Temporal change in such biomarkers, particularly in response to pharmacological interventions and/or mechanical circulatory support, can guide management and predict outcome.
Circulation, Ahead of Print. Anthracycline chemotherapy and chest-directed radiotherapy are the most well-studied cardiotoxic therapies, and dose reduction, use of cardioprotection for anthracyclines, and modern radiotherapy approaches have contributed to improved cardiovascular outcomes for survivors.
Circulation: Heart Failure, Ahead of Print. The genotype-phenotype interdependence causes unpredictable phenotypic penetrance that results in a variety of signs and symptoms and patient outcomes. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA.
BackgroundWe aimed to develop and validate a prognostic score to predict outcomes after endovascular treatment in acute ischemic stroke.MethodsThe prognostic score was developed based on the ACTUAL (Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke) registry. The validation cohort was derived from the Captor trial.
Strnad explains the need for noninvasive biomarkers in AATD liver disease and early research about circulating Z-polymer’s potential association with clinically relevant adverse outcomes.
After treatment, three-months major adverse cardiovascular events (MACE) were assessed as the primary outcome. This therapeutic effect is likely due to the active components of FFDS targeting key proteins: LPL, CD36, FABPpm, L-FABP, LCAT, and CEPT.Clinical Trial Registration[link] identifier (ChiCTR2400080149).
BackgroundIntracranial anterior circulation large artery occlusion (ACLAO) is a predominant cause of ischemic stroke. Although collateral circulation plays a critical role in stroke outcomes, the genetic and environmental factors affecting collateral development are not fully understood.
Adult cardiovascular care centered on the patient can improve individuals' experiences and their medical outcomes, according to a new American Heart Association Scientific Statement published today in Circulation.
In this review, we summarize the diagnostic and prognostic tools for ICI-myocarditis, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, with emphasis on circulating biomarkers.
Material and methods This is a retrospective analysis of the patients with OHCA and return of spontaneous circulation (ROSC) in the community who attended the cardiac catheter laboratory in a DGH between 1 September 2021 and 25 September 2023. The study aims to validate the MIRACLE2 score in a district general hospital (DGH).
The association between BACSS and outcomes was evaluated using adjusted logistic regression. In patients receiving endovascular treatment, associations of BACSS and time from puncture to recanalization with outcomes were evaluated, including an interaction term (BACSSpuncture to recanalization) to assess effect modification.
Circulation, Ahead of Print. It also sets out to advance this mission, focusing on how digital tools and, in particular, artificial intelligence may provide clinical and mechanistic insights, address bias in clinical studies, and facilitate education and implementation science to improve cardiovascular and stroke outcomes.
This study aimed to clarify the dynamics and role of circulating peripheral MAIT cells in acute ischemic stroke patients.Methods:We enrolled patients with acute ischemic stroke who admitted to Jichi Medical University Hospital, classifying them into severe (NIHSS 10) and mild (NIHSS <10) groups and outpatients were also enrolled as control.
Background:The effectiveness and safety of intravenous Tirofiban as an adjunct to endovascular therapy (EVT) in posterior circulation patients with tandem lesions (PCTL) remain uncertain.Methods:This study utilized individual patient data pooled from two multicenter observational studies: the BASILAR and the PERSIST registries.
If pulmonary hypertension is additionally involved with vasoplegic syndrome, circulation management becomes much more complicated. The aim of this study is to investigate whether pituitrin is beneficial for the postoperative outcomes in patients with pulmonary hypertension undergoing cardiac surgery.
Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).
Circulation, Ahead of Print. This American Heart Association scientific statement serves as an update to the 2012 statement on the evaluation and management of neurodevelopmental outcomes in children with congenital heart disease.
Circulation, Ahead of Print. Every 10 years, the American Heart Association (AHA) Emergency Cardiovascular Care Committee establishes goals to improve survival from cardiac arrest.
Circulation: Cardiovascular Interventions, Ahead of Print. High-volume MVr centers and high-volume TEER centers have better outcomes than low-volume centers, respectively. High-volume MVr centers and high-volume TEER centers have better outcomes than low-volume centers, respectively.
However, EVT outcomes may vary based on patient age and collateral status. This study examines the interaction between age and collateral status on EVT outcomes in VBAO patients.Methods:We retrospectively analyzed VBAO patients who underwent EVT from a prospectively maintained database between January 2014 and January 2024.
Introduction:Aspiration and stent retriever thrombectomy are the primary approaches for endovascular management of posterior circulation stroke. However, no significant differences were observed in key clinical outcomes such as mortality and favorable recovery. Stroke, Volume 56, Issue Suppl_1 , Page ATMP82-ATMP82, February 1, 2025.
BackgroundAnterior circulation stroke (ACS) differs from posterior circulation stroke (PCS) in several aspects. Primary outcome was occurrence of END at 7 days, defined as 2point increase in National Institutes of Health Stroke Scale score compared with baseline. Journal of the American Heart Association, Ahead of Print.
Precision Medicine: Personalizing Prevention for Better Outcomes Precision medicine provides tools to customize prevention and treatment plans based on individual risk factors. A 2022 study published in Circulation demonstrated that earlier LDL-C reduction leads to compounded cardiovascular benefits over time.
Circulation, Volume 150, Issue Suppl_1 , Page A4141869-A4141869, November 12, 2024. Evidence supports high-quality chest compressions as a vital factor to achieving return of spontaneous circulation (ROSC) and improving outcomes after cardiac arrest. Survival is about 25% with significant variation across the country.
Real-world low-risk patients undergoing TAVR have a greater risk of adverse events at one year, particularly mortality, when compared with published clinical trial data, according to a study published April 3 in Circulation.
Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke.
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