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Circulation, Ahead of Print. Optimal NT-proBNP cut points for HFpEF rule out (optimizing sensitivity) and rule in (optimizing specificity) were derived and tested, stratified by obesity and atrial fibrillation.
Circulation, Ahead of Print. Background: Patients with heart failure, a preservedejectionfraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure.
Circulation: Heart Failure, Ahead of Print. BACKGROUND:The therapeutic armamentarium for heart failure with preservedejectionfraction (HFpEF) remains notably constrained. compared with single condition exposure 5.21.3% (obesity), 6.73.5% (hypertension), and 9.01.1% (diabetes;P<0.001).
Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preservedejectionfraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. In the STEP-HFpEF trial, once-weekly semaglutide 2.4 across domains;P<0.05
Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. BACKGROUND:Obesity and adiposity are associated with an increased risk of heart failure with preservedejectionfraction (HFpEF); yet, specific underlying mechanisms remain unclear. 1.70) and 1.25 (95% CI, 1.03–1.52),
Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.
Circulation, Volume 150, Issue Suppl_1 , Page A4139791-A4139791, November 12, 2024. Intro:Drug Development for Heart failure with PreservedEjectionFraction (HFpEF) is a major challenge facing cardiovascular research due to its complex pathophysiology and existence of comorbidities, leading to recognize distinct HFpEF phenogroups.
STEP-HFpEF DM 5 ( NCT04916470 ) explored the effects of semaglutide in obesity-related HF with preservedejectionfraction (HFpEF) and type 2 diabetes. Investigators randomized 616 adult patients with HFpEF and obesity to receive either once weekly semaglutide (n=310) or placebo (n=306). It is able to deliver 3.5L/min
Circulation, Volume 150, Issue Suppl_1 , Page A4118122-A4118122, November 12, 2024. Patients studied were older (68 years old), white (90%), obese (average BMI 34 kg/m2) individuals with an average LVEF of 61%. Baseline demographics are shown in Table 1. Outcomes and multivariate linear regression results are shown in Table 2.
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