Cardiology Update

DECEMBER 11, 2023

Previous studies have associated obesity with negative changes in the right ventricle using imaging techniques. However, the connection between obesity and more direct measures of right ventricle function, particularly those reflecting hemodynamic consequences, have been unclear. Original article: Circ Heart Fail. 2023;16:e010524.

Obesity 52

Obesity Hospital Outcomes Heart Failure 52

Cardiometabolic Health Congress

JULY 25, 2023

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

DAIC

JUNE 18, 2024

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. Obesity rates are expected to climb from 43.1%

Heart Disease 105

Heart Disease Blood Pressure Strokes Stroke 105

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4125500-A4125500, November 12, 2024. Background:Impaired left atrial (LA) function is observed in obese patients, however, there is little information on when LA dysfunction begins to appear. kg/m2; obese (n=15), ≧20 kg/m2.

Obesity 40

Obesity BMI Blood Pressure Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4143390-A4143390, November 12, 2024. Clinical and hemodynamic implications of having obesity in group 1 PH remain unknown.Hypothesis. There was no difference in survival among patients with and without obesity (HR 1.15; 95% CI 0.95-1.38; Obese patients had higher RAP (12.8 ± 6.8

Obesity 40

Obesity Pulmonary Hypertension Diabetes 40

Circulation

MARCH 9, 2025

Circulation, Volume 151, Issue 10 , Page 669-671, March 11, 2025.

Obesity 45

Obesity Circulation 45

Journal of the American Heart Association

DECEMBER 29, 2023

The goal of this study was to investigate the contribution of the renin–angiotensin–aldosterone system to the mechanism by which MSEW increases blood pressure and vasomotor sympathetic tone in obese male mice.Methods and ResultsMice were exposed to MSEW during postnatal life. Undisturbed litters served as controls.

Obesity 40

Obesity Blood Pressure Diet Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144999-A4144999, November 12, 2024. Obesity is associated with increased cardiovascular risk and adverse cardiac changes such as left ventricular hypertrophy (LVH) and in TOF higher body mass index (BMI) contributed to increase risk. mL/m2, p=0.04; RVEDVi 157.4±21.5 vs RVEDV 297.6±56.6

Obesity 40

Obesity BMI Pulmonary Circulation 40

Journal of the American Heart Association

MARCH 18, 2024

Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure.

Circulation 40

Circulation Obesity Heart Failure Cardiovascular Disease 40

Circulation: Heart Failure

SEPTEMBER 12, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. Fasting blood samples collected at the time of the cardiopulmonary exercise test were used to assay obesity-related biomarkers. 1.70) and 1.25 (95% CI, 1.03–1.52), 1.70) and 1.25 (95% CI, 1.03–1.52),

Biomarkers 40

Biomarkers Obesity Exercise Preserved Ejection Fraction 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141434-A4141434, November 12, 2024. A growing body of clinical trial data shows GLP-1 receptor agonist medications (GLP-1s) are not only effective in treating obesity but also demonstrate significant impact on the reduction of cardiovascular risk. inches (n=3,682).

Obesity 40

Obesity Risk Factors Circulation Outcomes 40

Circulation: Heart Failure

OCTOBER 27, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010524, November 1, 2023. The role of obesity in RV dysfunction and adverse outcomes is unclear.METHODS:We examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. P<0.001).

Obesity 40

Obesity Outcomes Heart Failure Pulmonary 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4138745-A4138745, November 12, 2024. Insulin signaling was assessed 15 minutes after stimulation with 17 nM insulin.Results:Esaxerenone improved insulin sensitivity (P<0.05) without altering metabolic parameters in HFD-induced obese and db/db mice.

Obesity 40

Obesity Blood Pressure Diet Diabetes 40

Frontiers in Cardiovascular Medicine

DECEMBER 5, 2024

The molecular mechanisms underlying the impaired effects of altered lipoproteins have been studied in numerous in vitro and in vivo studies, and have been extensively analyzed in coronary atherosclerosis, especially in the context of pathologies such as dyslipidemia, diabetes, obesity, and metabolic syndrome.

Circulation 40

Circulation Stroke Strokes Atherosclerosis 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4112652-A4112652, November 12, 2024. Background:Metabolic syndrome and obesity are known to increase the incidence of lung cancer. 0.98, p = 0.040; MUO: adjusted HR 0.76, 95% CI 0.60-0.96, 0.96, p = 0.022).Conclusions:After

Obesity 40

Obesity Cancer Outcomes Circulation 40

Cardiovascular Diabetology

JANUARY 27, 2024

Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of-function.

Obesity 52

Obesity Circulation Research 52

Circulation

NOVEMBER 17, 2024

Circulation, Ahead of Print. Background: Patients with heart failure, a preserved ejection fraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure. The broad spectrum of effects was reflected in benefits on the hierarchical composite (win ratio 1.63, 95%CI, 1.17, 2.28;P=0.004).Conclusions:

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Obesity Quality of Life 40

Circulation

JUNE 4, 2024

Circulation, Ahead of Print. to 26.8%) and obesity (43.1% BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. in 2020 to 61.0% Diabetes (16.3% to 60.6%) will increase, whereas hypercholesterolemia will decline (45.8%

Risk Factors 81

Risk Factors Cardiovascular Disease Strokes Stroke 81

Circulation: Heart Failure

JANUARY 28, 2025

Circulation: Heart Failure, Ahead of Print.

Obesity 40

Obesity Bicuspid/Mitral Stenosis Heart Failure 40

DAIC

JUNE 28, 2024

As part of its centennial, earlier this month, the Association published alarming cardiovascular health projections in its flagship peer-reviewed scientific journal Circulation. The new fund expects to start deploying capital in late 2024. At least 6 in 10 U.S. trillion price tag – tripling the current direct and indirect costs.

Cardiovascular Disease 105

Cardiovascular Disease Obesity Research Heart Disease 105

Dr. Paddy Barrett

DECEMBER 13, 2024

When it comes to cardiovascular disease, two of the biggest risk factors we must consider are: ApoB concentration - A measure of the number of circulating lipid particles. Not all circulating ApoB particles will transition across the artery wall, but some will. Trends in the number of obese and severely obese people by region.

Heart Disease 97

Heart Disease BMI Diabetes Cardiovascular Disease 97

Circulation

SEPTEMBER 2, 2024

Circulation, Volume 150, Issue 10 , Page e224-e225, September 3, 2024.

Preserved Ejection Fraction 45

Preserved Ejection Fraction Quality of Life Article Heart Failure 45

Circulation: Heart Failure

JANUARY 26, 2024

Circulation: Heart Failure, Ahead of Print.

Heart Failure 40

Heart Failure Pharmacology Obesity Outcomes 40

Circulation: Cardiovascular Quality & Outcomes

NOVEMBER 11, 2024

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.

Obesity 40

Obesity Circulation Outcomes 40

European Journal of Heart Failure

DECEMBER 22, 2023

Abstract Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations are lower in patients with obesity. Conclusions The risk of HHF varies across BMI categories for any given range of circulating NT-proBNP. to 4.7%; p-trend = 0.059).

Heart Failure 75

Heart Failure BMI Obesity Article 75

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146967-A4146967, November 12, 2024. Overall BMI was normal, however 17% (5 of 30) were overweight or obese (Table 1).The Objectives:Physically active lifestyles are important for patients with congenital heart disease, including Fontan. The less active Fontan had higher fat% (24.8±8.7

Quality of Life 40

Quality of Life Exercise Circulation Congenital Heart Disease 40

Circulation

NOVEMBER 11, 2023

Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. In the STEP-HFpEF trial, once-weekly semaglutide 2.4 across domains;P<0.05

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Preserved Ejection Fraction Quality of Life Obesity Heart Failure 40

Circulation

JANUARY 24, 2024

Circulation, Ahead of Print.

Heart Disease 81

Heart Disease Peripheral Arterial Disease Strokes Stroke 81

MIBHS

FEBRUARY 28, 2025

Exercise: Regular physical activity strengthens the heart and improves blood circulation. Maintain a Healthy Weight: Obesity amplifies the effects of genetic predispositions by contributing to high cholesterol, hypertension, and diabetes. Aim for at least 150 minutes of moderate aerobic activity per week.

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141522-A4141522, November 12, 2024. Bariatric surgery is an effective treatment for morbid obesity, with most patients achieving significant weight control within 1-2 years post-surgery. Quantitative pyrosequencing was performed on all patients.

Obesity 40

Obesity Cholesterol Outcomes Circulation 40

Circulation: Heart Failure

JANUARY 28, 2025

Circulation: Heart Failure, Ahead of Print. The generated organoids were then subjected to HFpEF-associated, comorbidity-inspired conditions, such as hypertension, diabetes, and obesity-related inflammation. compared with single condition exposure 5.21.3% (obesity), 6.73.5% (hypertension), and 9.01.1% (diabetes;P<0.001).

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Preserved Ejection Fraction Heart Failure Obesity Diabetes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140513-A4140513, November 12, 2024. Of the sample, Filipino adults had the highest prevalence rates for most conditions, except for physical inactivity and overweight/obesity. Asian Indian adults exhibited uptrends in overweight/obesity (AAPC: 1.1%,p< p< 0.001).

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Risk Factors Cardiovascular Disease Obesity Heart Attack 40

Circulation

JANUARY 22, 2025

Circulation, Ahead of Print. Optimal NT-proBNP cut points for HFpEF rule out (optimizing sensitivity) and rule in (optimizing specificity) were derived and tested, stratified by obesity and atrial fibrillation.

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Preserved Ejection Fraction Outpatient Heart Failure BMI 55

Stroke Journal

JANUARY 30, 2025

Older adults with obesity and metabolic syndrome may have decreased elimination of the xylitol metabolite xylose, which may explain the higher observed risk of thrombosis and stroke in older adults who consume foods with sugar alcohols. However, multiomics studies of both xylitol metabolites and these miRs in humans have not been done.

Thrombosis 40

Thrombosis Obesity Strokes Stroke 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4139791-A4139791, November 12, 2024. Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) l) for 8 weeks.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Hypertension Blood Pressure Obesity 40

Circulation

APRIL 1, 2025

Circulation, Ahead of Print. However, their involvement in HFpEF remains largely unexplored.METHODS:We examined cardiac lymphatic alterations in mice with HFpEF with comorbid obesity and hypertension, and in heart tissues from patients with HFpEF.

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Preserved Ejection Fraction Obesity Heart Failure Hypertension 45

Circulation: Genomic and Precision Medicine

NOVEMBER 28, 2023

Circulation: Genomic and Precision Medicine, Ahead of Print. Background:Proteomic profiling could potentially disclose new pathophysiological pathways for cardiovascular diseases (CVD) and improve prediction at the individual level.

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Cardiovascular Disease Myocardial Infarction Obesity Heart Failure 40