Stroke Journal

JANUARY 30, 2025

The significance of cranial bone marrow-derived leukocytes following ischemic stroke in the setting of ischemia/reperfusion remains uncertain. As a result, the exact percentages of cranial- and peripheral-derived neutrophils could easily be quantified and tracked, both in circulation and in the post-mortem brain.

Ischemia 40

Ischemia Circulation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Studying PMN recruitment and lifespan in ischemic stroke may offer insight into these failures in clinical trials and advance therapeutic development.Methods:PMNs were briefly pulse-labeled with 5-Ethynyl-2-deoxyuridine (EdU) to determine PMN lifespan and migration pattern following ischemia/reperfusion in stroke.

Ischemia 40

Ischemia Stroke Strokes Circulation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionIntracranial atherosclerotic disease (ICAD) is associated with up to 32% of posterior circulation strokes.1 5 However, most of the existing literature focuses on anterior circulation. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.

Stents 40

Stents Stent Circulation Stroke 40

Journal of the American Heart Association

FEBRUARY 14, 2024

RUPP offspring also had increased circulating B cells, cytolytic natural killer cells, and increased circulating AT1‐AA, which were normalized with maternal rituximab treatment. Maternal blood and tissues were collected. Immune cells were measured via flow cytometry, and AT1‐AA was quantified using a contraction bioassay.

Ischemia 40

Ischemia Blood Pressure Circulation Hypertension 40

Stroke Journal

FEBRUARY 1, 2024

Objective:Forward head posturing (FHP) has been associated with chronic anatomic vertebral artery disturbances possibly leading to posterior circulation ischemia. The data supporting FHP as a true risk factor of posterior circulation stroke has not been well established. There was a significant difference of 5.2

Risk Factors 40

Risk Factors Circulation Atrial Fibrillation Stroke 40

Stroke Journal

JANUARY 4, 2024

These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included. Our results are in line with the literature on the anterior circulation. Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Ischemia 40

Circulation: Cardiovascular Imaging

AUGUST 19, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 8 , Page e017210, August 1, 2024.

Ischemia 40

Ischemia Cardiovascular Imaging Circulation 40

Circulation

NOVEMBER 13, 2024

Circulation, Ahead of Print. Advances in cardiovascular imaging have improved the ability to identify coronary artery stenosis in patients with KD, yet knowledge gaps remain regarding optimal frequency of serial imaging and the best imaging modality to identify those at risk for inducible myocardial ischemia.

Aneurysm 81

Aneurysm Myocardial Infarction Cardiovascular Imaging Ischemia 81

Circulation: Cardiovascular Quality & Outcomes

FEBRUARY 26, 2025

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. BACKGROUND:The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data.

Ischemia 40

Ischemia Heart Disease Angina Anatomy 40

Circulation: Cardiovascular Interventions

NOVEMBER 6, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. Background:Myocardial bridges (MBs) are prevalent and can be associated with acute and chronic ischemic syndromes.

Ischemia 40

Ischemia Exercise Angina Cardiovascular Interventions 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113494-A4113494, November 12, 2024. To elucidate this relationship, we investigated gut microbiota dynamics in response to immunosuppression and cell therapy in a nonhuman primate (NHP) cardiac ischemia/reperfusion (IR) model, with controlled genetic, dietary, and environmental factors.

Ischemia 40

Ischemia Transplant Heart Transplant Biomarkers 40

Circulation: Cardiovascular Interventions

DECEMBER 28, 2023

Circulation: Cardiovascular Interventions, Ahead of Print.

Ischemia 40

Ischemia Cardiovascular Interventions Circulation 40

Dr. Smith's ECG Blog

NOVEMBER 19, 2016

DISCUSSION: The 12-lead EKG EMS initially obtained for this patient showed severe ischemia, with profound "infero-lateral" ST depression and reciprocal ST elevation in lead aVR. The ECG cannot diagnose the etiology of ischemia; it only the presence of ischemia, from whatever etiology. Circulation. Circulation 67, No.

Ischemia 40

Ischemia Cardiogenic Shock Aortic Stenosis 40

Circulation

FEBRUARY 19, 2024

Circulation, Volume 149, Issue 8 , Page 635-637, February 20, 2024.

Ischemia 53

Ischemia Circulation 53

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page ASu104-ASu104, November 12, 2024. Background:The incidence of cardiac arrest (CA) increases with age, leading to poorer neurological outcomes after the return of spontaneous circulation (ROSC) in the elderly.

Ischemia 40

Ischemia Cardiac Arrest Circulation Outcomes 40

Circulation: Cardiovascular Imaging

NOVEMBER 27, 2024

Circulation: Cardiovascular Imaging, Ahead of Print.

Ischemia 40

Ischemia Cardiovascular Imaging Bicuspid/Mitral Circulation 40

Circulation

APRIL 14, 2024

Circulation, Volume 149, Issue 16 , Page 1254-1257, April 16, 2024.

Quality of Life 49

Quality of Life Ischemia Circulation 49

Circulation: Cardiovascular Quality & Outcomes

FEBRUARY 26, 2025

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.

Ischemia 40

Ischemia Circulation Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

We developed an ED triage diagnostic algorithm termed, “Dizzy-7”, based on evidence incorporating key history and physical examination elements derived in patients with acute posterior circulation ischemia.

Circulation 40

Circulation Stroke Strokes Ischemia 40

Dr. Smith's ECG Blog

SEPTEMBER 29, 2024

This usually represents posterior OMI, but in tachycardia and especially after cardiac arrest, this could simply be demand ischemia, residual subendocardial ischemia due to the low flow state of the cardiac arrest. This rules out subendocardial ischemia and is diagnostic of posterior OMI. V4-5 continue to show STD.

Cardiac Arrest 109

Cardiac Arrest STEMI Ischemia SCAD 109

Dr. Smith's ECG Blog

OCTOBER 23, 2023

Edited by Bracey, Meyers, Grauer, and Smith A 50-something-year-old female with a history of an unknown personality disorder and alcohol use disorder arrived via EMS following cardiac arrest with return of spontaneous circulation. Circulation. The described rhythm was an irregular, wide complex rhythm. JAMA Intern Med. 2017.3191.

Tachycardia 130

Tachycardia Cardiac Arrest ICU Blog 130

Stroke Journal

FEBRUARY 1, 2024

The primary outcome measure was successful recanalization defined as modified Thrombolysis in Cerebral Ischemia (mTICI) score of 2b or higher. Data from 29 stroke centers for 10,229 AIS patients treated with MT for LVO between January 2010 and December 2022 was investigated.

Circulation 40

Circulation Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

The bootstrap resampling method was considered internal validation of the model.Results:Age (< 70 years), premorbid status (mRS 0), National Institutes of Health Stroke Scale (NIHSS) (< 20), and recanalization status after the MT (modified Thrombolysis in Cerebral Ischemia [mTICU] ≥2b) were related to 90-day mRS 0-3.

Stroke 40

Stroke Strokes Circulation Outcomes 40

Dr. Smith's ECG Blog

DECEMBER 7, 2023

Circulation: Cardiovascular Interventions , 7(5), 645–655. This proves effective treatment of the recurrent ischemia. The patient had no further symptoms of ischemia. EKG 3 is diagnostic for developing re-occlusion, and EKG 4 proves that the nitrates relieved the ischemia. = Buller, C. Starovoytov, A., Robinson, S.,

SCAD 123

SCAD Ischemia Coronary Artery Disease Cardiomyopathy 123

Dr. Smith's ECG Blog

JANUARY 1, 2013

Precordial ST depression may be subendocardial ischemia or posterior STEMI. I have warned in the past that one must think of other etiologies of ischemia when there is tachycardia. Whether it is subendocardial ischemia or posterior STEMI, if you cannot get it to resolve, you must activate the cath lab. There is no ST elevation.

STEMI 52

STEMI Ischemia Chest Pain Myocardial Infarction 52

Dr. Smith's ECG Blog

MARCH 9, 2013

For those who depend on echocardiogram to confirm the ECG findings of ischemia, this should be sobering. All of Wellens' cases in his studies (1, 2) had all of: 1) preserved R-waves 2) resolution of pain 3) restored flow to the anterior wall through either a) an open artery or b) collateral circulation. Lessons: 1. Lessons: 1.

Chest Pain 52

Chest Pain Myocardial Infarction Ischemia Angina 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147504-A4147504, November 12, 2024. Vorapaxar was associated with a significantly less rate of hospitalization for acute limb ischemia (Risk Ratio [RR] 0.57, 95% Confidence Interval (CI) 0.39 Randomized controlled trials (RCTs) comparing Vorapaxar in patients with PAD were included.

Peripheral Arterial Disease 40

Peripheral Arterial Disease Ischemia Hospital Outcomes 40

Circulation: Cardiovascular Imaging

DECEMBER 6, 2023

Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Stress perfusion cardiovascular magnetic resonance can be performed without rest perfusion for the quantification of ischemia burden. The absence of ischemia by either analysis strategy conferred a favorable long-term prognosis. P<0.001, for both).CONCLUSIONS:In

Ischemia 40

Ischemia Cardiovascular Imaging Heart Disease Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4119062-A4119062, November 12, 2024. Endothelial BMPER deletion impaired blood flow recovery and vascular remodeling in the AVF and a hindlimb ischemia (HLI) model, with the latter reversed by BMP9/10 blocking antibodies (bAbs).

Physiology 40

Physiology Ischemia Diabetes Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4129709-A4129709, November 12, 2024. Prolonged anti-platelet effects and targeted anti-inflammatory effects of aspirin were validated in intact mice and hindlimb ischemia models, respectively.

Atherosclerosis 40

Atherosclerosis Diet Circulation Ischemia 40

Dr. Smith's ECG Blog

MAY 29, 2017

Ischemia 3. The ST depression in precordial leads suggest still more widespread ischemia, so the exact culprit is not at all clear. In Wellens' original studies, every case had either an open artery (LAD) or collateral circulation. Wellens' syndrome is due to reperfusion or good collateral circulation 4. Normal Variant 2.

Chest Pain 52

Chest Pain Ischemia Circulation Heart Disease 52

Dr. Smith's ECG Blog

JUNE 11, 2021

Similarly, STEMI guidelines call for urgent angiography for refractory ischemia or electrical/hemodynamic instability, regardless of ECG findings. So there is now high pre-test probability + refractory ischemia + Modified Sgarbossa + dynamic ECG changes. So the RCA was stented. Learning points 1.

Chest Pain 52

Chest Pain Cardiac Arrest Ischemia Cardiogenic Shock 52

Circulation

JANUARY 18, 2024

Circulation, Ahead of Print. BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation.

Myocardial Infarction 45

Myocardial Infarction Heart Transplant Ischemia Transplant 45

Circulation

DECEMBER 20, 2024

Circulation, Ahead of Print. However, the roles of PW1 and DNPB in ECM production by cardiac fibroblasts during myocardial ischemia are not yet understood.METHODS:To induce myocardial damage, we performed left anterior descending coronary artery ligation.

Myocardial Infarction 45

Myocardial Infarction Ischemia Heart Disease Circulation 45

Circulation: Cardiovascular Quality & Outcomes

JANUARY 8, 2024

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. We quantified PFO closure among individuals with ≥2 years of preprocedure coverage to establish indications, classified hierarchically as stroke/systemic embolism, migraine, transient ischemia attack, or other.Results:We identified 5315 patients undergoing PFO closure (51.8%

Atrial Fibrillation 40

Atrial Fibrillation Embolism Ischemia Strokes 40

Stroke Journal

JANUARY 30, 2025

Collateral status is a well-documented marker of reperfusion and mortality in patients with large vessel occlusion (LVO) anterior circulation strokes, which account for approximately one-third of AIS. Modified Treatment in Cerebral Ischemia (mTICI) score was used to determine reperfusion status, with mTICI > 2b considered successful.

Document 40

Document Circulation Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

JANUARY 26, 2024

BACKGROUNDSteroids have pleiotropic neuroprotective actions including the regulation of inflammation and apoptosis which may influence the effects of ischemia on neurons, glial cells, and blood vessels. Stroke: Vascular and Interventional Neurology, Ahead of Print.

Ischemia 40

Ischemia Stroke Strokes Hemorrhage 40