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Preeclampsia and other hypertensive disorders of pregnancy—which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy—carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.
ObjectiveClinical practice currently faces a significant shortfall in specific biomarkers needed for diagnosing right ventricular (RV) remodeling in patients with pulmonary hypertension (PH).
Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation. Journal of the American Heart Association, Ahead of Print.
Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health.
Their findings were published this week in Circulation. Hunter Medical Research Institute and University of Newcastle researcher Professor Murray Cairns, along with his Precision Medicine team, have discovered a way of predicting who will respond to blood pressure treatments to lower sodium in the body.
Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,
This genetic association study investigates if mendelian randomization can identify associations between circulating cardiovascular disease–related proteins and hypertensive disorders of pregnancy.
For example, blood pressure changes during exercise (EBP) can reveal a latent tendency toward future development of hypertension. At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk.
Hypertension, Ahead of Print. BACKGROUND:The mesenteric venous reservoir plays a vital role in mediating blood volume and pressure changes and is richly innervated by sympathetic nerves; however, the precise nature of venous sympathetic regulation and its role during hypertension remains unclear. mL/min) but efflux in SH rats (−1.0±1.0
If pulmonary hypertension is additionally involved with vasoplegic syndrome, circulation management becomes much more complicated. The aim of this study is to investigate whether pituitrin is beneficial for the postoperative outcomes in patients with pulmonary hypertension undergoing cardiac surgery.
Hypertension, Ahead of Print. Colocalization analyses were then used to investigate whether the circulating proteins and blood pressure traits shared causal genetic variants.
Jesudian, MD, discusses strategies to prevent the progression of cirrhosis, which include targeting microbiome abnormalities to improve the gut-liver axis, enhancing circulatory function, treating the inflammatory state, and addressing portal hypertension.
Pulmonary arterial hypertension (PAH) is a rare form of pulmonary hypertension. As a result, the right side of the heart has to pump harder to transport blood to the lungs and the blood pressure in the pulmonary circulation rises. It occurs because progressive vascular changes cause the small pulmonary arteries to narrow.
Patients with pulmonary hypertension associated with a left-right shunt include a wide spectrum of pathophysiological substrates, ranging from those characterized by pulmonary over-circulation to those with advanced pulmonary vascular disease.
BackgroundChronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral smallvessel disease. Journal of the American Heart Association, Ahead of Print. Microvessels were isolated for gene expression profiling and invitro pericyte expansion.
Circulation: Heart Failure, Ahead of Print. Background:Distinguishing hypertrophic cardiomyopathy (HCM) from other cardiomyopathies with left ventricular hypertrophy (LVH), such as hypertensive LVH, transthyretin amyloid cardiomyopathy (ATTR-CM), and aortic stenosis (AS), is sometimes challenging. and |log2(fold change)| >0.5
These groundbreaking developments offer a paradigm shift in the management of resistant hypertension, especially when it is extremely difficult to achieve blood pressure control through conventional means, such as lifestyle modifications and various drug therapies. But what is resistant hypertension, and why does it require renal denervation?
Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure.
Hypertension, Ahead of Print. Such stress alters the content and increases the release of syncytiotrophoblast extracellular vesicles (STB-EVs) into the maternal circulation. Such stress alters the content and increases the release of syncytiotrophoblast extracellular vesicles (STB-EVs) into the maternal circulation.
Hypertension, Ahead of Print. BACKGROUND:High circulating DPP3 (dipeptidyl peptidase 3) has been associated with poor prognosis in critically ill patients with circulatory failure. In such situation, DPP3 could play a pathological role, putatively via an excessive angiotensin peptides cleavage.
Circulation, Volume 150, Issue Suppl_1 , Page A4131796-A4131796, November 12, 2024. The study specifically focused on early detection of hypertension and diabetes. Hypertension was categorized for individuals with systolic blood pressure ≥115 mmHg or diastolic blood pressure ≥75 mmHg. for 30-second data segments and 80.9%
Circulation, Ahead of Print. BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH).
Additional details and the notice can be found here: [link] The Paradise uRDN system is designed to lower blood pressure by denervating the sympathetic nerves surrounding the renal arteries, reducing the overactivity that can lead to hypertension.
Objective:Forward head posturing (FHP) has been associated with chronic anatomic vertebral artery disturbances possibly leading to posterior circulation ischemia. The data supporting FHP as a true risk factor of posterior circulation stroke has not been well established. The average C2 tilt of cases was 22.9 degrees compared to 17.7
Circulation, Ahead of Print. BACKGROUND:Although combination antiretroviral therapy has increased life expectancy in people living with HIV, it has led to a marked increase in the prevalence of hypertension, the cause of which is unknown.
Circulation, Ahead of Print. We projected through 2050, overall and by age and race and ethnicity, accounting for changes in disease prevalence and demographics.RESULTS:We estimate that among adults, prevalence of hypertension will increase from 51.2% in 2020 to 61.0% Diabetes (16.3% to 26.8%) and obesity (43.1% to 3.8%), stroke (3.9%
BackgroundThis study aimed to investigate the causal relationships between branched‐chain amino acids (BCAAs) and the risks of hypertension via meta‐analysis and Mendelian randomization analysis.Methods and ResultsA meta‐analysis of 32 845 subjects was conducted to evaluate the relationships between BCAAs and hypertension.
Circulation, Volume 150, Issue Suppl_1 , Page A4141387-A4141387, November 12, 2024. Additionally, 94 cases of tumor-associated hypertension and 96 cases of primary hypertension were randomly selected for comparison. 13.21) vs. (80.41±10.71) 10.71) mmHg,t=2.332,P=0.021], daytime average diastolic blood pressure [(85.98±13.19)
That increase was greatest among younger patients, males, minorities, and patients with hypertension and diabetes. That’s far higher than previous estimates, including a pair of JAMA and Circulation studies that estimated nationwide AFib rates of 2.26M and 5.1M When these results are applied across the U.S., adult population.
Circulation, Ahead of Print. Balloon pulmonary angioplasty continues to gain traction as a treatment option for patients with chronic thromboembolic pulmonary disease with and without pulmonary hypertension.
Circulation, Volume 150, Issue Suppl_1 , Page A4146960-A4146960, November 12, 2024. The chi-squared test compared sociodemographic characteristics between HTN stages I and II.Results:Data from 1580 hypertensive participants with blood pressure readings over 130/80 mmHg with or without anti-hypertensive treatment was analyzed.
Circulation, Volume 150, Issue Suppl_1 , Page A4147331-A4147331, November 12, 2024. Hypertension can often be seen in settings of obesity, leptin resistance, and insulin resistance, though the exact mechanistic interaction of these conditions has yet to be elucidated. Single cell sequencing was performed on circulating immune cells.
Circulation, Ahead of Print. BACKGROUND:Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach to lower blood pressure (BP) but are not equally effective across all individuals. Intervention studies are warranted.
Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025. Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults with few cardiovascular risk factors.
Circulation, Volume 150, Issue Suppl_1 , Page A4143390-A4143390, November 12, 2024. Introduction:Obesity is rising in prevalence worldwide and co-exists in patients with group 1 pulmonary hypertension (PH). Clinical and hemodynamic implications of having obesity in group 1 PH remain unknown.Hypothesis. vs 1.38 ± 0.84 mL/mm of Hg, p=.0002)
Objective In Fontan circulation, pulmonary arterial hypertension (PAH)-targeted therapies could improve the patients’ exercise capacity. This study aimed to investigate the effects of PAH agents on different exercise parameters in stable Fontan patients by synthesising evidence of randomised controlled trials (RCTs).
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Background:Undiagnosed hypertension and uncontrolled blood pressure (BP) are common and contribute to excess cardiovascular morbidity and mortality. At 6 months, 154 of 323 (48%) participants had a new hypertension diagnosis of whom 88 achieved target BP control.
Steno-occlusive changes in the posterior cerebral arteries (PCAs) may contribute to worsened outcomes in patients with MMD; however, there is little information on the incidence and natural history of posterior circulation MMD (PCMMD). The overall postoperative, progression-free survival in patients with PCMMD was 95.4% at 1 year, 82.4%
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