Circulation

OCTOBER 21, 2024

Circulation, Ahead of Print. BACKGROUND:Arteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptorlike kinase 1 (Alk1) are linked to hemorrhagic telangiectasia type 2.METHODS:Endothelial-specific

Hemorrhage 40

Hemorrhage Transplant Ischemia Pulmonary 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionFlow diverters have demonstrated reliable safety and effectiveness for the treatment of selected anterior circulation intracranial aneurysms. However, posterior circulation aneurysms comprise around 10‐15% of all aneurysms, and they frequently present atypical morphological and anatomical characteristics.

Aneurysm 40

Aneurysm Circulation Hemorrhage Outcomes 40

Stroke Journal

JANUARY 30, 2025

In stroke, it has been associated with infarct growth, hemorrhagic transformation, and poor outcomes. WMD severity may also indicate poor collateral circulation, compromise of the blood brain barrier, and microvascular dysfunction, predicting higher infarct burden and stroke severity.

Hemorrhage 40

Hemorrhage Outcomes Hypertension Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:The effectiveness and safety of intravenous Tirofiban as an adjunct to endovascular therapy (EVT) in posterior circulation patients with tandem lesions (PCTL) remain uncertain.Methods:This study utilized individual patient data pooled from two multicenter observational studies: the BASILAR and the PERSIST registries.

Circulation 40

Circulation Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:Symptomatic intracranial hemorrhage (sICH) is the most dreaded complication after reperfusion therapy for acute ischemic stroke. Results:MT in the anterior circulation was associated with a significantly higher risk of sICH as compared with no-MT (RR: 1.46; 95%CI: 1.03-2.07; 2.07; P = 0.037). 1.03; P = 0.079).

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Posterior circulation tandem occlusion was defined as stroke due to intracranial vertebral (V4), basilar, or posterior cerebral artery (PCA) occlusions, with tandem steno-occlusive lesion >70% of the extracranial vertebral artery and impaired distal flow or partial filling of the VA from collaterals.

Circulation 40

Circulation Outcomes Thrombolysis Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Several CT, CTA, CTP‐based radiological biomarkers of hemorrhagic transformation (HT) were reported.To ConclusionMultimodal CT‐based scoring system may provide highly reliable predictive model of hemorrhagic transformation in acute ischemic stroke. Rates of HT were approximately five times higher in patients with score ≥ 3.ConclusionMultimodal

Hemorrhage 40

Hemorrhage Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

In patients with intracerebral hemorrhage (ICH), it is important to quickly and accurately individualize the treatment decision by quantitatively predicting the hematoma progression using medical information collected on admission. Stroke, Volume 55, Issue Suppl_1 , Page ATP170-ATP170, February 1, 2024.

Hemorrhage 40

Hemorrhage Circulation Hospital Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Increase in mean lesional iron content (≥6%) measurement by QSM and vascular permeability (≥ 40%) assessed by DCEQP MRI have been associated with new bleeding in cavernous angiomas (CA), and are used as monitoring biomarkers in clinical trial of pharmacotherapy in CAs with symptomatic hemorrhage (SH).

Biomarkers 40

Biomarkers Hemorrhage Circulation Stroke 40

Circulation

JUNE 30, 2024

Circulation, Volume 150, Issue 1 , Page e20-e20, July 2, 2024.

Atrial Fibrillation 45

Atrial Fibrillation Hemorrhage Circulation Strokes 45

Stroke Journal

FEBRUARY 1, 2024

Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Strokes 40

Stroke: Vascular and Interventional Neurology

AUGUST 8, 2023

BackgroundThe Rapid Arterial oCclusion Evaluation (RACE) score can identify patients with anterior circulation large‐vessel occlusion (aLVO) ischemic stroke for transportation to a comprehensive stroke center for endovascular thrombectomy.

Hemorrhage 40

Hemorrhage Stroke Strokes Document 40

Stroke Journal

JANUARY 30, 2025

Blood circulating CC-motif chemokine 11 (CCL11) increases in rodents and humans with age. To simulate aging with an increase of circulating CCL11 level, we intraperitoneally administered the CCL11 once every 4d for 1mo into the middle-aged mice. Stroke, Volume 56, Issue Suppl_1 , Page ATP196-ATP196, February 1, 2025.

Stroke 40

Stroke Strokes Outcomes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

90-day modified Rankin score (mRS) 0-2, mortality and symptomatic hemorrhage were used as secondary outcomes. The primary outcome measure was successful recanalization defined as modified Thrombolysis in Cerebral Ischemia (mTICI) score of 2b or higher.

Circulation 40

Circulation Stroke Strokes Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Introduction:Several pre-hospital scales predict ischemic stroke due to large vessel occlusion; however, these scales often fail to detect atypical endovascular thrombectomy (EVT) cases, including posterior circulation and distal vessel occlusion.

Stroke 40

Stroke Strokes Hemorrhage Hospital 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147397-A4147397, November 12, 2024. We assessed in-hospital mortality, intracranial hemorrhage, gastrointestinal (GI) hemorrhage, anemia requiring blood transfusion, acute kidney injury (AKI), and hospital length of stay (LOS) between both groups.

Heart Disease 40

Heart Disease Hospital Inpatient Outcomes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140574-A4140574, November 12, 2024. Herein, we present a case of recurrent left atrial myxoma with hemorrhagic, cerebral embolization.Case Report:A 34-year-old male presented with acute onset numbness and tingling of the left arm.

Embolism 40

Embolism Hemorrhage Echocardiogram Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored in clinical trials. Stroke, Volume 56, Issue Suppl_1 , Page ATMP83-ATMP83, February 1, 2025.

Stroke 40

Stroke Strokes Hemorrhage Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionPosterior circulation strokes account for 20% of ischemic strokes (1). Optimal management for posterior circulation strokes has been studied less than for anterior circulation strokes (2). Following embolization, repeat imaging showed no new infarcts and no new or worsening hemorrhage.

Stroke 40

Stroke Strokes Embolism Hemorrhage 40

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2023

Veno-venous ECMO can support oxygenation but is not designed to help circulation. Applying ECMO is also associated with substantial multisystem morbidity due to a systemic inflammatory response, hemorrhagic stroke, renal dysfunction, and bleeding, which must be factored into the outcomes.

Embolism 56

Embolism Pulmonary Cardiac Arrest Hemorrhage 56

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4129945-A4129945, November 12, 2024. The rates for hemorrhagic stroke were 0.68%, 0.55%, 0.81%, and 4.90% for the same groups. Background:Data are limited regarding risk of stroke for temporary mechanical circulatory support (tMCS) device treated acute myocardial infarction (AMI).Methods:The

Inpatient 40

Inpatient Myocardial Infarction Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Secondary outcomes included degree of disability (modified Rankin scale range), symptomatic intracranial hemorrhage, any intracranial hemorrhage, and mortality.Results:Among 455 eligible patients, the median age was 68 years, and median Alberta Stroke Program Early Computed Tomography Score was 3 (interquartile range 3-4).

Stroke 40

Stroke Strokes Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

During the waiting period, 166 patients (26.6%) experienced CI, and 17 patients (2.3%) had cerebral hemorrhage. The incidence rates of CI and cerebral hemorrhage were 10.49 No specific risk factors for cerebral hemorrhage during the waiting period were identified. per 1000 person-months, respectively.

Pediatrics 40

Pediatrics Hemorrhage Risk Factors Circulation 40

All About Cardiovascular System and Disorders

MARCH 26, 2024

This highlights one of the most important complications of Eisenmenger syndrome, that is airway hemorrhage. Airway hemorrhage can occur in those who ascend to high altitude and during air travel. But if you go by the statistics, majority of the hemorrhages occur at sea level or ordinary level of height.

VSD 52

VSD Pulmonary Hemorrhage Hypertension 52

Stroke Journal

JANUARY 30, 2025

Introduction:Moyamoya is a progressive steno-occlusive cerebrovascular arteriopathy of bilateral anterior circulation. Twenty-three (34%) children had complete occlusion of bilateral anterior circulation without asymmetry at diagnosis. This left-sided predilection was statistically significant (p=0.03).

Pediatrics 40

Pediatrics Circulation Risk Factors Strokes 40

Stroke Journal

JANUARY 30, 2025

The AIS patients with LVO in the anterior circulation within 24 hours of symptom onset, baseline modified Rankin Scale (mRS) score 2, and Alberta Stroke Program Early CT Score (ASPECTS) score 6 were included. Methods:This was a retrospective, single-center observational study.

Stroke 40

Stroke Strokes Blood Pressure Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

We defined: first pass effect (FPE: eTICI2c at first pass), successful recanalization (mTICI 2b), excellent recanalization (mTICI 2c), intracranial hemorrhage (ICH) and symptomatic ICH (sICH).Results:437 Further analysis will explore specific anatomical markers that increase the risk of complications, especially in distal occlusions.

Stroke 40

Stroke Strokes Outcomes Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% vs. 6.1%, p = 0.0326), and symptomatic intracerebral hemorrhage (7.3% p = 0.0027), and symptomatic intracranial hemorrhage (OR 5.2, vs. 6.1%, p = 0.0002), deep vein thrombosis (7.3

ICU 40

ICU Thrombolysis Stroke Strokes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113411-A4113411, November 12, 2024. The primary outcome was a composite of the incidence of myocardial infarction and ischemic and hemorrhagic stroke, obtained by tracking the medical use data of the first-ever ICD-10 codes. years and median follow-up duration was 15.9

Myocardial Infarction 40

Myocardial Infarction Hypertension Cardiovascular Disease Outcomes 40

Stroke: Vascular and Interventional Neurology

JANUARY 26, 2024

This trial investigates the efficacy and safety of low‐dose methylprednisolone (2 mg/kg IV for 3 days) as adjunctive therapy for patients with acute ischemic stroke undergoing endovascular therapy within 24 hours from symptom onset.METHODSThe MARVEL (Methylprednisolone as Adjunctive Therapy for Acute Large Vessel Occlusion: A Randomized Double‐Blind, (..)

Ischemia 40

Ischemia Strokes Stroke Circulation 40

Stroke Journal

JANUARY 30, 2025

This study aimed to identify the difference of collateral patterns between mild stroke patients with END and those without.Methods:AIS patients presenting within 24 hours from last known well, with a baseline NIHSS5 and anterior circulation LVO or severe stenosis were included. 1.22,22.18] P=0.026).Conclusions:Higher

Stenosis 40

Stenosis Stroke Strokes Circulation 40

Stroke Journal

FEBRUARY 1, 2024

We defined two binary outcomes: (1) functional clinical outcome (modified Rankin Scale 0-2) and (2) early symptomatic intracerebral hemorrhage (sICH). Among patients who underwent emergency intracranial stenting, 66 (30.6%) received intravenous thrombolytic treatment.

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionCurrent evidence supports endovascular therapy (EVT) for eligible patients with acute ischemic stroke in the anterior and posterior circulation. 1.56, P= 0.28; I2 = 26%, Figure A) and the results of the anterior circulation subgroup showed non‐statistically significant difference (OR = 1.22, 95% CI: 0.90–1.67,

Stroke 40

Stroke Strokes Circulation Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

After several patients in this series developed subarachnoid hemorrhage from a ruptured mycotic aneurysm, we proceeded to institute weekly cerebral angiography protocol. The aneurysms were seen exclusively in the posterior circulation. The average size of aneurysms when first detected was 5.0 ± 3.8

Aneurysm 40

Aneurysm Angioplasty Hemorrhage Outcomes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142098-A4142098, November 12, 2024. The impact of significant neutrophilia was not studied during clinical trials using Granulocyte Colony Stimulating Factor (G-CSF) to boost the deficient circulating endothelial progenitor cell count. No hemorrhage occurred over the 30 day course.

Document 40

Document Circulation Ischemia Hemorrhage 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 28, 2023

Mortality and symptomatic intracranial hemorrhage rates were similar between the treatment groups for both occlusion types.ConclusionsA minority of patients with intracranial carotid occlusion presented with ICA‐I occlusion in the HERMES population. versus 25%;P=0.296) and ICA‐L/T occlusion (32.5% versus 14.4%;P<0.001),

Hemorrhage 40

Hemorrhage Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

Thrombolysis 40

Thrombolysis Stroke Strokes Stents 40