Circulation, Heart Transplant and Outcomes

Review of the Global Activity of Heart Transplant

Circulation: Heart Failure

APRIL 4, 2025

Circulation: Heart Failure, Ahead of Print. Heart failure is a global disease with significant morbidity. Heart transplant (HT) can be a lifesaving therapy for select patients with end-stage heart failure.

Heart Transplant

Heart Transplant Transplant Heart Failure Article

Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients

Circulation: Cardiovascular Imaging

APRIL 2, 2024

Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:In heart transplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV dysfunction in the stable phase after heart transplantation is associated with long-term adverse outcomes is unknown.

Heart Transplant

Heart Transplant Transplant Outcomes Myocardial Infarction

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

DAIC

FEBRUARY 13, 2024

THE TEXAS HEART INSTITUTE 2024 milla1cf Tue, 02/13/2024 - 17:56 February 13, 2024 — Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure.

Transplant

Transplant Pediatrics Heart Transplant Research

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association

Circulation

FEBRUARY 26, 2024

Circulation, Ahead of Print. Cardiogenic shock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. Older adults have been largely excluded from analyses of therapeutic options in patients with cardiogenic shock.

Cardiogenic Shock

Cardiogenic Shock Best Practices Heart Transplant Transplant

Longitudinal Trends in Donor and Recipient Risk Profile, and Clinical Outcomes, for Donation After Circulatory Death Heart Transplantation

Circulation: Heart Failure

NOVEMBER 6, 2023

Circulation: Heart Failure, Ahead of Print.

Heart Transplant

Heart Transplant Transplant Heart Failure Circulation

Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy

Circulation

JANUARY 9, 2025

Circulation, Ahead of Print. BACKGROUND:The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation (HT) in 2016 for pediatric patients and 2018 for adult patients.

Congenital Heart Disease

Congenital Heart Disease Pediatrics Cardiomyopathy Transplant

Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy

DAIC

APRIL 30, 2024

The highly positive outcomes observed in primate models highlight the potential of this strategy. Heart attacks typically kill millions of cardiac muscle cells, leaving the heart in a weakened state. Cardiovascular diseases are still among the top causes of death worldwide, and especially prevalent in developed countries.

Transplant

Transplant Heart Transplant Myocardial Infarction Heart Attack

Abstract 4146823: Trends and Outcomes in Heart Failure Admissions and Cardiogenic Shock Among Patients with Congenital Heart Disease

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146823-A4146823, November 12, 2024. Heart transplant rates were low but increased slightly in 2020 for patients without CHD, with DV and SV CHD patients showing fluctuating rates peaking in 2018 and 2019, then declining in 2020.

Cardiogenic Shock

Cardiogenic Shock Congenital Heart Disease Heart Failure Congenital

Impact of Advanced Therapy Centers on Characteristics and Outcomes of Heart Failure Admissions

Circulation: Heart Failure

MARCH 8, 2024

Circulation: Heart Failure, Ahead of Print. Centers performing at least 1 heart transplant or left ventricular assist device were classified as ATCs. Patient characteristics, outcomes, and procedural volume were compared among 3 cohorts: admissions to non-ATCs, admissions to ATCs, and transfers to ATCs.

Heart Failure

Heart Failure Cardiogenic Shock Outcomes Cardiac Arrest

Abstract 4144326: Mid-Term Outcomes of Surgical Resection of Pediatric Cardiac Fibroma and Modified Ventricular Reconstruction Procedure

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144326-A4144326, November 12, 2024. It has changed the fate of young patients with large tumors who would have otherwise needed heart transplants, offering high suture strength and reducing postoperative complications. During a median follow-up period of 17.4

Pediatrics

Pediatrics Outcomes Heart Transplant Aneurysm

Waitlist Outcomes in Candidates With Rare Causes of Heart Failure After Implementation of the 2018 French Heart Allocation Scheme

Circulation: Heart Failure

FEBRUARY 1, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:In 2018, an algorithm-based allocation system for heart transplantation (HT) was implemented in France. The cumulative incidence of waitlist mortality estimated with competing risk analysis and incidence of transplantation were compared between diagnosis groups.

Heart Failure

Heart Failure Congenital Heart Disease Congenital Cardiomyopathy

Abstract 4113494: Gut Microbiota Modulation by Immunosuppression and Cardiac Cell Therapy in a Nonhuman Primate Ischemia/Reperfusion Model of Cardiac Regeneration

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113494-A4113494, November 12, 2024. End-stage ischemic heart disease necessitates heart transplantation, and emerging cell therapy presents a promising solution to address donor scarcity.

Ischemia

Ischemia Transplant Heart Transplant Biomarkers

Abstract 4146828: Downregulation of ADAR1 Attenuates Hypothermic Cardioprotection in Aged Donor Hearts During Transplantation

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146828-A4146828, November 12, 2024. Heart transplantation remains a vital treatment for end-stage heart failure, yet the scarcity of suitable donor hearts makes the treatment unavailable to many patients in critical need.

Transplant

Transplant Heart Transplant Heart Dysfunction Heart Failure

Abstract 4134590: Procedural Related Major Adverse Events of Cardiac Catheterization in Pediatric Patients with Cardiomyopathy: Insights from IMPACT Registry

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4134590-A4134590, November 12, 2024. We collected demographic, pre-procedural, procedural, and outcome-related variables. We aim to describe the rate of MAE in children with cardiomyopathy undergoing cardiac catheterization. were females.

Cardiomyopathy

Cardiomyopathy Pediatrics Heart Transplant Heart Failure

Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5

Circulation: Heart Failure

JANUARY 16, 2025

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Right ventricular dysfunction (RVD) is common in patients with heart failure with reduced ejection fraction, and it is associated with poor prognosis. Plasma levels of FMOD and FBLN5 were significantly associated with patient outcomes (P=0.005;P=0.004).

Biomarkers

Biomarkers Heart Failure Heart Transplant Transplant

Abstract 4146920: Potential Effects of Preoperative Blood Transfusions on Cardiac Transplantation Patient’s Postoperative Condition

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146920-A4146920, November 12, 2024. Cox regression results showed that there is an increased risk of mortality in patients who did not receive transfusions before transplant (p<0.0001).Conclusion:While

Transplant

Transplant Heart Transplant Risk Factors Outcomes

Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation

Circulation

JANUARY 18, 2024

Circulation, Ahead of Print. BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation.

Myocardial Infarction

Myocardial Infarction Heart Transplant Ischemia Transplant

Highlights of ACC 2024

Cardiology Update

APRIL 9, 2024

The percent change from baseline in fasting triglycerides (TG) at six months served as the primary outcome measure. The percent change from baseline in fasting TG at six months served as the primary outcome measure. Among patients with HFpEF, those who received the shunt experienced poor outcomes than those who did not.

Angina

Angina Myocardial Infarction Aortic valve Coronary Artery Disease

Abstract 4139383: Non-Inferiority Of Extracorporeal Photopheresis To Immunosuppression Therapy In Heart Transplantation Rejection

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4139383-A4139383, November 12, 2024. Background:Immunosuppressive (IS) therapy is currently used as first-line treatment for heart transplant (HTx) rejection. However, they are not without complications, and less toxic therapies are needed.

Heart Transplant

Heart Transplant Transplant Cardiovascular Disease Outcomes

Racial Differences in Donor-Derived Cell-Free DNA and Mitochondrial DNA After Heart Transplantation, on Behalf of the GRAfT Investigators

Circulation: Heart Failure

FEBRUARY 20, 2024

Circulation: Heart Failure, Ahead of Print. Background:Black heart transplant patients are at higher risk of acute rejection (AR) and death than White patients. The primary composite outcome occurred in 43% and 55% of Black patients at 1 and 2 years, compared with 23% and 27% in White patients,P<0.001.

Heart Transplant

Heart Transplant Transplant Heart Failure Outcomes

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Adult Cardiac Surgery Database Lead Author Title Publication Date Jacob Raphael Red Blood Cell Transfusion and Pulmonary Complications: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis The Annals of Thoracic Surgery January 2024 Joseph Sabik Multi-Arterial versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Program Designations Access and Publications (A&P) 1 Participant User File (PUF) 2 Task Force on Funded Research (TFR) 3 Special Projects 4 Adult Cardiac Surgery Database Lead Author Title Publication Date William Keeling 2 National Trends in Emergency Coronary Artery Bypass Grafting European Journal of Cardiothoracic Surgery October 2023 Jake (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Abstract 4138589: Prognostic implications of Biventricular systolic and diastolic strain in diabetes without coronary artery diseases.

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4138589-A4138589, November 12, 2024. All patients were prospectively followed for development of new outcome/cardiac events which included hospitalization for acute HF, CVS-related death, heart transplantation, and also diabetic complications.

Coronary Artery Disease

Coronary Artery Disease Diabetes Heart Transplant Tricuspid

Cardiovascular Update

Review of the Global Activity of Heart Transplant

Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients

Revolutionary Genomic Study Sheds Light on Immune Microenvironment in Transplanted Pediatric Hearts

Webinars

Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association

Longitudinal Trends in Donor and Recipient Risk Profile, and Clinical Outcomes, for Donation After Circulatory Death Heart Transplantation

Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy

Using Stem Cell-derived Heart Muscle Cells to Advance Heart Regenerative Therapy

Abstract 4146823: Trends and Outcomes in Heart Failure Admissions and Cardiogenic Shock Among Patients with Congenital Heart Disease

Impact of Advanced Therapy Centers on Characteristics and Outcomes of Heart Failure Admissions

Abstract 4144326: Mid-Term Outcomes of Surgical Resection of Pediatric Cardiac Fibroma and Modified Ventricular Reconstruction Procedure

Waitlist Outcomes in Candidates With Rare Causes of Heart Failure After Implementation of the 2018 French Heart Allocation Scheme

Abstract 4113494: Gut Microbiota Modulation by Immunosuppression and Cardiac Cell Therapy in a Nonhuman Primate Ischemia/Reperfusion Model of Cardiac Regeneration

Abstract 4146828: Downregulation of ADAR1 Attenuates Hypothermic Cardioprotection in Aged Donor Hearts During Transplantation

Abstract 4134590: Procedural Related Major Adverse Events of Cardiac Catheterization in Pediatric Patients with Cardiomyopathy: Insights from IMPACT Registry

Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5

Abstract 4146920: Potential Effects of Preoperative Blood Transfusions on Cardiac Transplantation Patient’s Postoperative Condition

Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation

Highlights of ACC 2024

Abstract 4139383: Non-Inferiority Of Extracorporeal Photopheresis To Immunosuppression Therapy In Heart Transplantation Rejection

Racial Differences in Donor-Derived Cell-Free DNA and Mitochondrial DNA After Heart Transplantation, on Behalf of the GRAfT Investigators

Published Research

Published Research

Abstract 4138589: Prognostic implications of Biventricular systolic and diastolic strain in diabetes without coronary artery diseases.

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