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Pictured Left to Right: Members and students of the McGill Gene Editing Laboratory at The Texas Heart Institute in Houston, Texas: Fansen Meng, PhD, Xiao Li, PhD, James Martin, MD, PhD, Rich Li, PhD (back), Maggie Lim (undergraduate student at Rice University front), Yuka Morikawa, PhD, Ann Bromley.
Circulation, Volume 150, Issue Suppl_1 , Page A4144084-A4144084, November 12, 2024. Despite being a hearttransplantation candidate, she declined revascularization and sought alternative treatments for angina, dyspnea, and daily activity limitations.
Kittleson, director of HeartFailure Research and director of Post Graduate Medical Education in HeartFailure and Transplantation, is an associate editor specializing in heartfailure. Levine Early Career Clinical Investigator Award from the American Heart Association.
Circulation: HeartFailure, Ahead of Print. Heartfailure is a global disease with significant morbidity. Hearttransplant (HT) can be a lifesaving therapy for select patients with end-stage heartfailure.
Circulation, Volume 150, Issue Suppl_1 , Page A4146823-A4146823, November 12, 2024. Hearttransplant rates were low but increased slightly in 2020 for patients without CHD, with DV and SV CHD patients showing fluctuating rates peaking in 2018 and 2019, then declining in 2020. Patients without CHD were older (mean age 71.5
Circulation, Ahead of Print. Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Acute heartfailure has an incidence ranging from 0.4%
Circulation, Volume 150, Issue Suppl_1 , Page A4146828-A4146828, November 12, 2024. Hearttransplantation remains a vital treatment for end-stage heartfailure, yet the scarcity of suitable donor hearts makes the treatment unavailable to many patients in critical need.
Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 452-461, October 1, 2023. Background:Many cardiovascular disorders propel the development of advanced heartfailure that necessitates cardiac transplantation. of patients with unexplained end-stage cardiomyopathy.
Circulation: HeartFailure, Ahead of Print. Centers performing at least 1 hearttransplant or left ventricular assist device were classified as ATCs. Patient characteristics, outcomes, and procedural volume were compared among 3 cohorts: admissions to non-ATCs, admissions to ATCs, and transfers to ATCs.
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Right ventricular dysfunction (RVD) is common in patients with heartfailure with reduced ejection fraction, and it is associated with poor prognosis.
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Cardiac allograft vasculopathy (CAV) is the leading cause of late graft dysfunction in hearttransplantation. Only patients in the moderate to high risk cluster developed the International Society for Heart and Lung Transplantation CAV 2-3 at 5 years (P=0.02).
Circulation, Volume 150, Issue Suppl_1 , Page A4134590-A4134590, November 12, 2024. The association between a lower rate of MAE and EMB persisted in the multivariate model when those with hearttransplant who had EMB were compared to those without hearttransplant who did not have EMB p=0.001.
Circulation, Volume 150, Issue Suppl_1 , Page A4142247-A4142247, November 12, 2024. Background:Cardiac transplantation remains the single most effective treatment for end-stage heartfailure. Autoradiography revealed68Ga-grazytracer accumulation in the transplantedheart. at POD 7 days; P<0.001).
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Cardiac allograft rejection is the leading cause of early graft failure and is a major focus of postheart transplant patient care.
Circulation, Volume 150, Issue Suppl_1 , Page A4144461-A4144461, November 12, 2024. Introduction:Left ventricular assist devices (LVADs) have become an increasingly common treatment option for patients with advanced heartfailure, serving as either a bridge to transplantation or destination therapy.
Circulation, Volume 150, Issue Suppl_1 , Page A4146466-A4146466, November 12, 2024. Background:Without timely intervention, pressure-overloading left ventricular (poLV) remodeling may become progressive and readily degenerate into heartfailure.
Circulation, Ahead of Print. BACKGROUND:Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease.
Circulation, Volume 150, Issue Suppl_1 , Page A4146624-A4146624, November 12, 2024. Introduction:Ventricular assist devices (VADs) present great promise as both bridge-to-transplant and destination therapies for patients with end-stage heartfailure.
Circulation, Ahead of Print. BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:A growing number of patients with tetralogy of Fallot develop left ventricular systolic dysfunction and heartfailure, in addition to right ventricular dysfunction.
suffer from heartfailure , and there are approximately 400,000 heart-failure-related deaths in this country each year. Patients with heartfailure often experience reduced mobility, quality of life and ability to work; the disease also represents a significant public health care burden.
Dilation: The chambers of the heart expand, making the walls thinner. Both forms of enlargement may compromise the heart’s ability to pump blood efficiently, leading to further complications like heartfailure. What Causes an Enlarged Heart? Here are some of the most common causes: 1.
Study shows that cardiac spheroids, derived from human induced pluripotent stem cells, can be easily transported and injected into damaged areas of the heart to promote its regeneration and recovery of function. Heart attacks typically kill millions of cardiac muscle cells, leaving the heart in a weakened state.
The HeartMate 3 is used for both short- and long-term support in pediatric and adult patients with severe left ventricular heartfailure. It can be used while waiting for a hearttransplant, to help the heart recover, or as a permanent solution when a transplant isn't an option.
Critical limb-threatening ischemia (CLTI) represents the end stage of peripheral artery disease (PAD), when poor circulation due to blockages in the arteries causes symptoms including numbness, sores that will not heal, gangrene, and extreme pain.
Circulation: Cardiovascular Imaging, Volume 17, Issue 1 , Page e015858, January 1, 2024. BACKGROUND:Advanced chronic kidney disease is associated with high cardiovascular risk, even after kidney transplant. years post-transplant. years post-transplant. A minority had abnormal MPI (n=58, 15%). 2.66];P=0.33).
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Clinical evaluation of central venous pressure is difficult, depends on experience, and is often inaccurate in patients with chronic advanced heartfailure. 0.84]) and confirmed in the validation cohort (receiver operating characteristic, 0.82 [95% CI, 0.73–0.92]).
Circulation: HeartFailure, Ahead of Print. BACKGROUND:In 2018, an algorithm-based allocation system for hearttransplantation (HT) was implemented in France. Secondary end points included access to HT and posttransplant mortality. 4.24];P=0.03).CONCLUSIONS:Our
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:In hearttransplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV dysfunction in the stable phase after hearttransplantation is associated with long-term adverse outcomes is unknown. 1.17];P=0.046).
The HeartMate II and 3 are used for both short- and long-term support in adult patients with severe left ventricular heartfailure. It can be used while waiting for a hearttransplant, to help the heart recover, or as a permanent solution when a transplant isn't an option.
Circulation: HeartFailure, Ahead of Print. BACKGROUND:Cardiac allograft vasculopathy (CAV) leads to impaired myocardial blood flow (MBF), increasing the risk of cardiovascular death or retransplant among hearttransplantation (HT) recipients. Elevated dd-cfDNA was defined as 0.12%.RESULTS:Two 0.71%];P=0.38).
Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 421-430, October 1, 2023. Background:Variants in theDMDgene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heartfailure, hearttransplantation, and ventricular arrhythmias.
Critical limb-threatening ischemia (CLTI) represents the end stage of peripheral artery disease (PAD), when poor circulation due to blockages in the arteries causes symptoms including numbness, sores that will not heal, gangrene, and extreme pain.
J Electrocardiol, 42 (2009), pp. e5 Article Download PDF Google Scholar 3 RNW Hauer, MGPJ Cox, JA Groeneweg Impact of new electrocardiographic criteria in arrhythmogenic cardiomyopathy Front Physiol, 3 (2012), p.
Investigators assessed if empagliflozin could lower the risk of hospitalization for heartfailure (HF) or death from cardiovascular disease (CVD). The Impella CP is a catheter-based, axial flow pump that pumps blood directly from the left ventricle into the circulation. It is able to deliver 3.5L/min
Adult Cardiac Surgery Database Lead Author Title Publication Date Jacob Raphael Red Blood Cell Transfusion and Pulmonary Complications: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis The Annals of Thoracic Surgery January 2024 Joseph Sabik Multi-Arterial versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million (..)
Program Designations Access and Publications (A&P) 1 Participant User File (PUF) 2 Task Force on Funded Research (TFR) 3 Special Projects 4 Adult Cardiac Surgery Database Lead Author Title Publication Date William Keeling 2 National Trends in Emergency Coronary Artery Bypass Grafting European Journal of Cardiothoracic Surgery October 2023 Jake (..)
Circulation: HeartFailure, Ahead of Print. Background:Black hearttransplant patients are at higher risk of acute rejection (AR) and death than White patients. The incidence of AR was higher in Black patients compared with White patients (43% versus 19%;P=0.002).
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