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Background We evaluated the potential of circulating bone morphogenetic protein 10 (BMP10) as a biomarker for atrial stress and remodelling in patients with heartfailure (HF), in comparison to N-terminal pro-B-type natriuretic peptide (NT-proBNP). We also assessed the predictive value of BMP10 for adverse clinical outcomes.
After severe heartfailure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.
Circulation, Ahead of Print. Mitochondria dysfunctions are well-known to participate in heartfailure (HF). Mitochondria dysfunctions are well-known to participate in heartfailure (HF). BACKGROUND:Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.
Circulation: HeartFailure, Ahead of Print. Initiatives to reveal asymptomatic gene carriers early in the disease should be encouraged, as it necessitates stringent patient follow-up and immediate treatment onset to reduce the burden of heartfailure hospitalization and mortality in hATTR-CA.
New Cleveland Clinic and Tufts University research shows that elevated levels of the gut microbiome trimethylamine N-oxide (TMAO) pathway led to a higher risk of heartfailure independent of other risk factors, according to a study of two large National Institutes of Health cohorts.
The diagnostic power of the candidate miRNA was further validated in 100 patients [20 with adaptive RV pressure overload; 20 with maladaptive RV pressure overload; 20 with left heartfailure (LHF); 19 with left ventricular hypertrophy and 21 controls].ResultsPAB
Initially discovered and developed by Orion Corporation in Finland, intravenous levosimendan is approved in 60 countries outside the United States for use in hospitalized patients with acutely decompensated heartfailure. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,
Circulation, Volume 150, Issue Suppl_1 , Page A4120990-A4120990, November 12, 2024. Background:Recent advancements have seen deep learning models help differentiate echocardiography images of patients with heartfailure with preserved ejection fraction (HFpEF) from normal controls.
Objectives In dyspneic patients with atrial fibrillation (AF) or obesity, the diagnostic performance of NT-proBNP for acute heartfailure is reduced. In patients with AF, the AUC decreased for ERFE in each cohort (NZ: 0.71, n = 105, SG: 0.61, n = 44) but increased in patients with obesity (NZ: 0.79, n = 150, SG: 0.87, n = 164).
Circulation: HeartFailure, Ahead of Print. The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heartfailure and cardiogenic shock.
Certain gut metabolites are linked to an increased risk of heartfailure, according to a study published Aug. 9 in Circulation: HeartFailure , an American Heart Association journal.
Circulation, Volume 151, Issue 2 , Page 149-158, January 14, 2025. BACKGROUND:Patients with heartfailure (HF) with mildly reduced or preserved ejection fraction face heightened long-term risks of morbidity and mortality. Baseline SGLT2i use was a prespecified subgroup.
BackgroundOral treatment with the exogenous ketone body 3hydroxybutyrate improves cardiac function in patients with heartfailure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Twelve patients with heartfailure with reduced ejection fraction were included. L/min (95% CI, 0.71.1
Dr. Sören Brandenburg have identified a protein that plays a central role in the heart's adaptation to increased stress. The results of the study were published in Circulation Research.
Circulation, Ahead of Print. BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heartfailure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction.
Some heartfailure patients with artificial hearts have been able to regenerate heart muscle, potentially paving the way for future heartfailure treatment options, according to a study published Nov. 21 in Circulation.
Our study aimed to evaluate whether circulating levels of growth differentiation factor-15 (GDF-15) could predict adverse changes in echocardiographic indexes of cardiac structure and function in an initially healthy populational familial cohort with a long follow-up (STANISLAS cohort).
The interaction between body mass index (BMI) and NT-proBNP with respect to heartfailure (HF) risk remains incompletely defined. Hospitalization for heartfailure (HHF) was examined across strata of baseline BMI and NT-proBNP. to 4.7%; p-trend = 0.059).
Circulation: HeartFailure, Ahead of Print. High out-of-pocket costs and financial toxicity related to heartfailure treatment are substantial concerns. Furthermore, heartfailure rarely occurs in isolation.
Circulation, Ahead of Print. BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heartfailure. Cardiomyocyte-specific overexpression ofIno80, its core catalytic subunit, induced heartfailure within 4 days.
Kittleson, director of HeartFailure Research and director of Post Graduate Medical Education in HeartFailure and Transplantation, is an associate editor specializing in heartfailure. Levine Early Career Clinical Investigator Award from the American Heart Association.
Circulation, Ahead of Print. Guideline-directed medical therapies and guideline-directed nonpharmacological therapies improve quality of life and survival in patients with heartfailure (HF), but eligible patients, particularly women and individuals from underrepresented racial and ethnic groups, are often not treated with these therapies.
BackgroundData on the use of implanted hemodynamic monitoring (IHM) in patients with Fontan circulation are limited. Heartfailure hospitalizations/year were similar before and after IHM (median, 1 [interquartile range, 0–1.0] P=0.268), though only 46% of heartfailure hospitalizations had associated IHM transmissions.
A research team co-led by a physician-scientist at the University of Arizona College of MedicineTucson's Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heartfailure.
This is where coronary circulation comes into play. Coronary circulation refers to the movement of blood through the network of coronary arteries and veins that supply the heart muscle (myocardium) itself. Step-by-Step Breakdown of Coronary Circulation 1.
Diabetes mellitus (DM) is associated with premature atherosclerotic disease, coronary artery disease (CAD) and chronic heartfailure (HF), leading to increased morbidity and mortality. Sodium-Glucose Co-transp.
We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD. Addition of protein biomarkers to traditional clinical models modestly improved the accuracy of predicting incident CMD, with the highest improvement for heartfailure (C-index ~0.2).
Circulation, Ahead of Print. With continued medical and surgical advancements, most children and adolescents with congenital heart disease are expected to survive to adulthood.
Circulation: HeartFailure, Volume 17, Issue 12 , Page e011629, December 1, 2024. Spironolactone, a steroidal mineralocorticoid receptor antagonist (MRA), has been used to treat patients with heartfailure (HF) for more than half a century.
For patients with heartfailure with preserved ejection fraction (HFpEF), endovascular treatment (EVT) improves left ventricular (LV) diastolic function, according to a study published online Sept. 9 in Circulation: HeartFailure.
Circulation, Volume 150, Issue Suppl_1 , Page A4148170-A4148170, November 12, 2024. Background:Cardiovascular disease is an important cause for mortality in cancer patients and cancer is a primary cause of non- cardiac mortality in patients with heartfailure. The primary outcome was 30-day all-cause hospital readmission.
Circulation: Cardiovascular Quality and Outcomes, Volume 17, Issue 12 , Page e011040, December 1, 2024. BACKGROUND:Posttraumatic stress disorder (PTSD) is associated with maladaptive dysregulation of stress response systems, which could lead to an increased risk of heartfailure. 95% CI, 2.67.3). 95% CI, 2.16.3]).
Circulation, Volume 150, Issue Suppl_1 , Page A4144084-A4144084, November 12, 2024. It is primarily indicated for refractory angina that is not amenable to PCI or CABG with the opinion of a cardiologist.
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