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Succinylation of SERCA2a at K352 Promotes Its Ubiquitinoylation and Degradation by Proteasomes in Sepsis-Induced Heart Dysfunction

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. SERCA2a (sarco/endoplasmic reticulum Ca2+ATPase type 2a), which plays a crucial role in controlling intracellular Ca2+signaling and myocardial cell function, is downregulated and inactivated during sepsis-induced heart dysfunction.

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Abstract 4146828: Downregulation of ADAR1 Attenuates Hypothermic Cardioprotection in Aged Donor Hearts During Transplantation

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4146828-A4146828, November 12, 2024. Heart transplantation remains a vital treatment for end-stage heart failure, yet the scarcity of suitable donor hearts makes the treatment unavailable to many patients in critical need.

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Trying to answer two casual queries on RV dysfunction

Dr. S. Venkatesan MD

Gorter TM, van Veldhuisen DJ, Bauersachs et al Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2016; 18: 226