Remove Circulation Remove Genetic predisposition Remove Heart Failure
article thumbnail

Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.

article thumbnail

Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004685, December 1, 2024. The female-specific positive association of PGSMDwith CAD risk was replicated in BioVU.CONCLUSIONS:Genetic predisposition to MD confers a greater risk of CVDs in females versus males, even in the absence of any depression diagnosis.

article thumbnail

Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

Circulation

Circulation, Ahead of Print. The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4.4