DAIC

MAY 6, 2024

Patients who transitioned to the oral daily formulation after a lengthy treatment with the weekly IV formulation improved further in this assessment of exercise tolerance, which is the primary endpoint of the ongoing Phase 3 LEVEL study. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,

Preserved Ejection Fraction 105

Preserved Ejection Fraction Heart Failure Pulmonary Hypertension 105

Circulation: Heart Failure

OCTOBER 23, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023. BACKGROUND:Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Exercise 40

Circulation

NOVEMBER 11, 2023

Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. mg improved symptoms, physical limitations and exercise function, and reduced inflammation and body weight.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Quality of Life Obesity Heart Failure 40

Circulation

DECEMBER 7, 2023

Circulation, Ahead of Print. BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction. Dapagliflozin did not improve these outcomes in patients with HF with preserved ejection fraction.

Preserved Ejection Fraction 84

Preserved Ejection Fraction Heart Failure Exercise Cardiomyopathy 84

Circulation: Heart Failure

SEPTEMBER 12, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. BACKGROUND:Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. mL/kg per min lower peak VO2(β, −2.35±0.19;P<0.001).

Biomarkers 40

Biomarkers Exercise Obesity Preserved Ejection Fraction 40

JAMA Cardiology

JULY 23, 2024

Among patients with heart failure with preserved ejection fraction (HFpEF), right ventricular (RV) dysfunction is strongly associated with an increased risk of morbidity and mortality.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Pulmonary Exercise 40

Circulation: Heart Failure

DECEMBER 18, 2023

Circulation: Heart Failure, Volume 16, Issue 12 , Page e010673, December 1, 2023. mm Hg with exercise (P<0.001). mm Hg with exercise (P<0.001). At peak exercise, RT was responsible for 64% (53%–76%) of end-diastolic pressure, whereas incomplete relaxation and stiffness accounted for the rest.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Cardiomyopathy Heart Failure 40