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Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Circulation: Heart Failure

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. We defined HFpEF based on the presence of elevated left ventricular filling pressures at rest or during exercise. We defined HFpEF based on the presence of elevated left ventricular filling pressures at rest or during exercise. P<0.001).

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Abstract 4146967: The Effects of Physical Activity Levels on Body Composition, Exercise Performance, Single Ventricle Function and Self-Perceived Quality of Life in Children and Adolescents with a Fontan Circulation.

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4146967-A4146967, November 12, 2024. This study aims to establish the effect of an active lifestyle in paediatric Fontan patients, determine its relationship with body composition, exercise capacity, ventricle function and quality of life.Methods:30 Fontan patients were recruited.

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Exercise And Heart Health: Finding The Perfect Balance

MIBHS

Exercise and heart health— you’ve probably heard of the correlation before. Engaging in exercise can significantly contribute to maintaining a healthy heart and reducing the risk of cardiovascular diseases. By addressing these risk factors, exercise significantly lowers the risk of developing cardiovascular diseases.

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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52
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Abstract 4139791: A short version of HFD/L-NAME mouse model enabling time-effective proof of concept studies to evaluate drugs targeting the cardiometabolic and mild hypertension associated HFpEF phenotype.

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4139791-A4139791, November 12, 2024. Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) l) for 8 weeks.

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Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients with Heart Failure with Preserved Ejection Fraction and Obesity: A Prespecified Analysis of the STEP-HFpEF Trial

Circulation

Circulation, Ahead of Print. Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. mg improved symptoms, physical limitations and exercise function, and reduced inflammation and body weight.

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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. Obesity rates are expected to climb from 43.1%