article thumbnail

Computational Modeling of Effects of PKP2 Gene Therapy on Ventricular Conduction Properties in Arrhythmogenic Cardiomyopathy

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Evidence from experimental systems and patients indicates that ventricular myocytes inPKP2arrhythmogenic cardiomyopathy have greatly reduced electrical coupling at gap junctions and reduced Na+current density.

article thumbnail

His-Ventricular Interval and Incident Pacemaker Implant in Over 3000 Ambulatory Patients Undergoing Invasive Electrophysiologic Procedures

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Volume 17, Issue 12 , Page e013285, December 1, 2024.

article thumbnail

Tiny pacemakers can safely stabilize newborns' hearts for up to two years

Medical Xpress - Cardiology

A pacemaker modified for newborns' tiny bodies safely and effectively stabilized their heart rhythms for up to two years, according to new research published in Circulation: Arrhythmia and Electrophysiology.

article thumbnail

Technologic Advances in Cardiac Electrophysiology

Circulation

Circulation, Volume 150, Issue 22 , Page 1745-1746, November 26, 2024.

article thumbnail

Patients diagnosed with new-onset, persistent AFib are more likely to have certain risk factors

Medical Xpress - Cardiology

The findings, led by investigators in the Smidt Heart Institute at Cedars-Sinai, published in Circulation: Arrhythmia and Electrophysiology. Patients who present with persistent atrial fibrillation at diagnosis are more likely to have certain risk factors as compared with patients with occasional atrial fibrillation (AFib).

AFIB 74
article thumbnail

Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1

Circulation

Circulation, Ahead of Print. Using a battery of assays, including immunohistochemistry, immuno-electron microscopy imaging, and action potential recording, we assessed the effect of loss ofCarm1function on cardiomyocyte cell growth, myofibril expansion, T-tubule formation, and electrophysiological maturation.

article thumbnail

In Vivo Endocardial and Epicardial Mapping of Human Sinus Node: From Electrical Landmarks to Anatomical Landmarks

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.