This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
Atherosclerotic plaque formation is modulated by genetic and environmental interactions. In this study, we examined the effects of ApoE deficiency and high fat diet (HFD) on plaque formation and immunomodulatory cellular and molecular mechanisms in mice models.Methods:Wild type and ApoE knockout (KO) mice were fed with normal or HFD.
Lp(a) is emerging as an important, yet under-recognized, potential risk factor for cardiovascular disease due to its ability to promote the development of plaques within artery walls, clot formation and aortic valve calcification. Circulation. Arnett DK et al. 2019 Sep 10;140(11):e563-e595. doi: 10.1161/CIR.0000000000000677.
Understanding Peripheral Artery Disease Peripheral artery disease or PAD is a condition in which plaque builds up in the arteries that lead to the legs and feet. Exercise helps improve blood circulation, strengthen the heart and manage weight—all of which can help reduce the risk of PAD.
Circulation, Volume 150, Issue Suppl_1 , Page A4132968-A4132968, November 12, 2024. To induce atherosclerosis, mice were fed high fat diet (HFD) for 6 weeks following partial ligation of left carotid artery in C57BL6 mice. MDSCs phenotype and functionality were assessed using CCR5 inhibitorin vitro(10-8M) andin vivo(i.p
Regular exercise, a balanced diet, and lifestyle choices such as not smoking and managing stress are all crucial for achieving and maintaining optimal cardiovascular health. Engaging in activities such as running, swimming, or cycling helps strengthen the heart, increase lung capacity, and improve blood circulation.
While much attention is given to modifiable risk factors such as diet, exercise, and smoking, the role of genetics in heart disease is equally critical yet less understood by the general public. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.
This is where coronary circulation comes into play. Coronary circulation refers to the movement of blood through the network of coronary arteries and veins that supply the heart muscle (myocardium) itself. Step-by-Step Breakdown of Coronary Circulation 1. Any interruption in this process can result in serious consequences.
Coronary Artery Disease (CAD) CAD, which involves the narrowing or blockage of coronary arteries due to plaque buildup, can reduce blood flow to the heart. Lifestyle Changes Making certain lifestyle adjustments can also improve heart function and reduce the risk of further enlargement: Maintain a healthy diet low in salt and saturated fats.
However, most adults will start to develop advanced plaque in their coronary arteries early in life. By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque.
Methods and results Atherosclerosis was established in C57BL/6N mice by injecting AAV-PCSK9 and 16 weeks of Western diet feeding, followed by switching to a chow diet to induce atherosclerosis regression. Here, we sought to investigate the role of autophagy activation during atherosclerosis regression.
Circulation, Ahead of Print. In a conventional Western diet model for 2 months, HEG1iECKOmice also showed an exacerbated atherosclerosis development in the arterial tree in both sexes and the aortic sinus in males but not in females.
PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. This plaque narrows the blood vessels and reduces blood flow to the legs and feet, which may significantly impair physical function, walking performance and quality of life.
Less quantities of healthier food may be consumed in the diet by those with higher intake of sugar sweetened beverages. Inflammatory cytokines causing unstable plaques lead on to cardiovascular events [1]. Circulation. Adiposity activates inflammatory cytokines, enhances risk of hypertension, dyslipidemia and diabetes mellitus.
We organize all of the trending information in your field so you don't have to. Join thousands of users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
40 
Let's personalize your content