Remove Circulation Remove Diet Remove Obesity
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Can the Recent Stanford Vegan vs. Omnivore Twin Study Inform Us about the “Optimal” Diet for Cardiometabolic Health?

Physiologically Speaking

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 69
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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. Obesity rates are expected to climb from 43.1%

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Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II

Journal of the American Heart Association

BackgroundWe have previously reported that male mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show sympathetic activation and increased blood pressure in response to a chronic high‐fat diet. At weaning, both control and MSEW offspring were placed on a low‐fat diet or a high‐fat diet for 20 weeks.

Obesity 40
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Can the Recent Stanford Vegan vs. Omnivore Twin Study Inform Us about the “Optimal” Diet for Cardiometabolic Health?

Physiologically Speaking

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 52
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Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association

Circulation

Circulation, Ahead of Print. to 26.8%) and obesity (43.1% The prevalences of poor diet, inadequate physical activity, and smoking are estimated to improve over time, whereas inadequate sleep will worsen. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. in 2020 to 61.0%

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Abstract 4138745: Blockade of Mineralocorticoid Receptor by Esaxerenone Improves Insulin Sensitivity in Obese Mice

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4138745-A4138745, November 12, 2024. Insulin signaling was assessed 15 minutes after stimulation with 17 nM insulin.Results:Esaxerenone improved insulin sensitivity (P<0.05) without altering metabolic parameters in HFD-induced obese and db/db mice.

Obesity 40
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Abstract 4139791: A short version of HFD/L-NAME mouse model enabling time-effective proof of concept studies to evaluate drugs targeting the cardiometabolic and mild hypertension associated HFpEF phenotype.

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4139791-A4139791, November 12, 2024. Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) l) for 8 weeks.