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For decades, high-carbohydrate diets have been considered the gold standard for fueling endurance activities, largely due to their ability to optimize muscle glycogen stores. Advocates of low-carb diets argue that fat adaptation can enhance endurance by increasing fat oxidation. What’s this all mean?
The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.
Circulation) A healthy vegan diet held a cardiometabolic advantage over omnivorous eating. (MedPage Today) -- Do people with a family history of cardiovascular disease have a particular need to consume more eicosapentaenoic/docosahexaenoic acids?
More contentious is whether ketogenic diets have any utility for exercise performance, especially among high-level athletes. Ketogenic diets are characterized as being very low in carbohydrates (less than 50 grams per day), modest in protein, and high in fat (more than 80% of total energy intake). What are ketones?
Poor sleep is associated with worse diet quality, and sleeping less causes people to eat more — and more of the wrong things. This article will discuss the bi-directional relationship between sleep and diet, explore the mechanisms of sleep-promoting foods, and explain why you might crave junk food when you’re sleep-deprived.
The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.
Circulation, Volume 150, Issue Suppl_1 , Page A4143445-A4143445, November 12, 2024. However, the moderating effects of age and gender on the relationship of diet quality, smoking status, and exercise to cardiovascular health are unknown. Introduction:Maintaining a heart-healthy lifestyle is crucial for good cardiovascular health.
Circulation, Volume 150, Issue Suppl_1 , Page A4142765-A4142765, November 12, 2024. Conclusions:Adherence to an unhealthy plant-based diet is associated with a higher CVD risk in people with prediabetes or diabetes, which may be partially attributed to low consumption of whole grains, high intake of SSB, and high blood cystatin C level.
trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. trillion by 2050, according to two American Heart Association ( AHA ) presidential advisories published June 4 in the AHA journal Circulation. The landscape of cardiovascular disease in the U.S. of the population. history," he said.
Circulation, Ahead of Print. The prevalences of poor diet, inadequate physical activity, and smoking are estimated to improve over time, whereas inadequate sleep will worsen. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. in 2020 to 61.0% Diabetes (16.3% to 26.8%) and obesity (43.1%
BackgroundWe have previously reported that male mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show sympathetic activation and increased blood pressure in response to a chronic high‐fat diet. At weaning, both control and MSEW offspring were placed on a low‐fat diet or a high‐fat diet for 20 weeks.
BackgroundBranchedchain amino acids (BCAAs), which are derived from the diet, are markedly elevated in cardiac tissue following myocardial infarction (MI). The low BCAA diet preserved stroke volume and cardiac output after MI, whereas the high BCAA diet promoted progressive decreases in cardiac function.
In this study, we examined the effects of ApoE deficiency and high fat diet (HFD) on plaque formation and immunomodulatory cellular and molecular mechanisms in mice models.Methods:Wild type and ApoE knockout (KO) mice were fed with normal or HFD. Targeted proteomic profiling identified the circulating inflammatory proteins.
Circulating proteins are the result of genetically inherited predispositions to diseases and the influences of environmental exposures, diet, lifestyle behaviours and the ageing process.
More than 90% of the Lp(a) level is influenced by variations in the genes controlling the Lp(a) particle production, 2 in which lifestyle interventions such as diet and exercise have no significant impact. Circulation. Arnett DK et al. 2019 Sep 10;140(11):e563-e595. doi: 10.1161/CIR.0000000000000677. 0000000000000677.
Abnormal readings can signal issues with circulation or lung function, prompting further investigation. Users can adjust their lifestyle choices, such as diet and exercise, based on real-time data to reduce cardiovascular risk. Sleep Monitoring Quality sleep is essential for heart health.
Circulation, Ahead of Print. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known.METHODS:We found that ApoE knockout mice fed a Western diet recapitulate many features of HFpEF. Metabolism-induced systemic inflammation links comorbidities with HFpEF.
Exercise helps improve blood circulation, strengthen the heart and manage weight—all of which can help reduce the risk of PAD. Healthy Diet A special peripheral artery disease diet plays an integral role in reducing and preventing this condition. Medications – Medications play a crucial role in managing PAD symptoms.
Circulation, Ahead of Print. Cardiomyocytes fromLdlr−/−mice with hematopoietic-specific loss ofTet2or wild-type control and fed a Western diet were isolated to evaluate calcium signaling dynamics and analysis. Mice underwent in vivo invasive electrophysiology studies and ex vivo optical mapping.
Regular exercise, a balanced diet, and lifestyle choices such as not smoking and managing stress are all crucial for achieving and maintaining optimal cardiovascular health. Engaging in activities such as running, swimming, or cycling helps strengthen the heart, increase lung capacity, and improve blood circulation.
Food & Drug Administration (FDA) to include pediatric patients aged eight and older with heterozygous familial hypercholesterolemia (HeFH) as an adjunct to diet and other LDL-C lowering therapies. Statement from Dr. Mary P.
Circulation, Volume 150, Issue Suppl_1 , Page A4115222-A4115222, November 12, 2024. Background:Poor self-care in patients with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) leads to increased diabetes complications and health costs. years) or T2DM (n = 84, mean age: 62.5) using REDCap during 2023.
Exercise helps strengthen your heart muscle, improves circulation, and lowers blood pressure and cholesterol levels, all of which are crucial for maintaining optimal cardiac health. Eat A Heart-Healthy Diet What you eat has a significant impact on your cardiac health.
Circulation, Ahead of Print. High-cholesterol diet–fed ApoE–/–mice with AVCAPIR knockout were used to examine the role of AVCAPIR in aortic valve calcification (AVC). BACKGROUND:Calcification of the aortic valve leads to increased leaflet stiffness and consequently results in the development of calcific aortic valve disease (CAVD).
Circulation, Volume 150, Issue Suppl_1 , Page A4133170-A4133170, November 12, 2024. The anatomical position of endothelial cells (ECs) between the circulating blood and vessel walls makes them the first to encounter and respond to cellular stressors in the bloodstream.
Circulation, Volume 150, Issue Suppl_1 , Page ASa1108-ASa1108, November 12, 2024. Diabetic mice were fed with high fat diet (HFD), and CA model was established by inducing ventricular fibrillation electrically. Previous studies have mentioned the aberrant autophagy in diabetic mice.
Circulation, Volume 150, Issue Suppl_1 , Page A4139791-A4139791, November 12, 2024. Intro:Drug Development for Heart failure with Preserved Ejection Fraction (HFpEF) is a major challenge facing cardiovascular research due to its complex pathophysiology and existence of comorbidities, leading to recognize distinct HFpEF phenogroups.
Circulation, Volume 150, Issue Suppl_1 , Page A4136995-A4136995, November 12, 2024. This will help to reduce the risk of ASCVD and mortality for the patients, promoting better management of lipid levels through medications, diet and regular monitoring.As
Circulation, Volume 150, Issue Suppl_1 , Page A4134456-A4134456, November 12, 2024. After 5 weeks of the diet, HFD mice and their littermate controls underwent baseline exercise testing and echocardiograms. Despite this, no therapies with mortality benefit exist for this syndrome.
Thus, this study aimed to investigate the association between circulating levels of Zn, Cu, and Zn/Cu ratio with CVD risk factors in the Qatari population. Maintaining optimal levels of these trace elements, either through diet or supplementation, may help reduce CVD risk.
Circulation, Volume 150, Issue Suppl_1 , Page A4141524-A4141524, November 12, 2024. vs. 7; p <0.001), cardioprotective diet (4.2 Background:Patient education is a core component of cardiac rehabilitation program and a part of the consensus statement for Cardiac rehabilitation delivery model for low resource settings.
Circulation, Volume 150, Issue Suppl_1 , Page A4134622-A4134622, November 12, 2024. These findings provide insights into the etiology of CHD and suggest the importance of diet for prevention of heterotaxy during diabetic pregnancy. However, the specific mechanism by which hyperglycemia disturbs the L-R axis still remains unsolved.
Lerodalcibep is a novel inhibitor of PCSK9 , a protein in the liver that reduces the liver’s ability to clear LDL cholesterol from the circulation. Both groups continued their diet and existing cholesterol-lowering medications. In addition, lerodalcibep was well-tolerated, with minimal adverse effects.” mL) monthly injection.
Circulation, Ahead of Print. Herein, we assessed the potential role and therapeutic value of USP28 (ubiquitin-specific protease 28) on the metabolic vulnerability of diabetic cardiomyopathy.METHODS:The type 2 diabetes mouse model was established using db/db leptin receptor–deficient mice and high-fat diet/streptozotocin–induced mice.
Circulation, Ahead of Print. Poorly designed urban provisioning systems are starkly evident worldwide, resulting in unprecedented exposures to adverse cardiometabolic risk factors, including limited physical activity, lack of access to heart-healthy diets, and reduced access to greenery and beneficial social interactions.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. BACKGROUND:Increased burden of socially determined vulnerabilities (SDV), which include nonmedical conditions that contribute to patient health, is associated with incident heart failure (HF). Mediators of this association have not been examined.
Circulation, Volume 150, Issue Suppl_1 , Page A4146692-A4146692, November 12, 2024. Background:Young adulthood (YA, 19–39 years) is the life stage of greatest increase in cardiovascular (CV) risk and decline in CV health (CVH).
Circulation, Volume 150, Issue Suppl_1 , Page A4132968-A4132968, November 12, 2024. To induce atherosclerosis, mice were fed high fat diet (HFD) for 6 weeks following partial ligation of left carotid artery in C57BL6 mice. MDSCs phenotype and functionality were assessed using CCR5 inhibitorin vitro(10-8M) andin vivo(i.p
Circulation, Volume 150, Issue Suppl_1 , Page A4132120-A4132120, November 12, 2024. a unique approach, we crossed DS model mice withApoE-null mice and fed them a high-fat diet (HFD) for 12 weeks to survey the effects of DS-related genes on atherosclerosis.
Circulation, Volume 150, Issue Suppl_1 , Page A4119926-A4119926, November 12, 2024. For the sodium intake in the subjects' diet, 45% exceeded the recommendation stated in the guidelines of less than 2,400 mg of sodium per day which was not statistically significant (p=0.077).Discussion
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