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Diabetes mellitus (DM) is associated with premature atherosclerotic disease, coronaryarterydisease (CAD) and chronic heart failure (HF), leading to increased morbidity and mortality. Sodium-Glucose Co-transp.
BackgroundGenomewide association studies have revealed numerous loci associated with coronaryarterydisease (CAD). Journal of the American Heart Association, Ahead of Print. These results suggest distinct regulatory mechanisms forTAGLN2.
BackgroundObservational studies have suggested the potential role of inflammatory factors in the risk of coronaryarterydisease (CAD). The weighted median, simple median, maximum likelihood, MR pleiotropy residual sum and outlier, and MR‐Egger methods were performed as sensitivity analyses. The odds ratio was 1.20 (95% CI, 1.08–1.33;P=6.83×10−4)
Circulation, Ahead of Print. BACKGROUND:Shared genetic and lifestyle risk factors may underlie the development of both coronaryarterydisease (CAD) and dementia.
Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004674, December 1, 2024. BACKGROUND:Genome-wide association studies identified a 20-Kb region of chromosome 8 (8q24.13) associated with plasma lipids, hepatic steatosis, and risk for coronaryarterydisease. locus to these traits.
Circulation, Volume 150, Issue Suppl_1 , Page A4140139-A4140139, November 12, 2024. Introduction:The cardio-ankle vascular index (CAVI) is a significant metric for evaluating arterial function. Recent statistics indicate that a high CAVI score has the potential to predict future cardiovascular disease (CVD) occurrences.
Key strategies include: Polygenic Risk Scores: Identifying Risk Early PRS helps identify young adults at high lifetime risk for coronaryarterydisease (CAD). A 2022 study published in Circulation demonstrated that earlier LDL-C reduction leads to compounded cardiovascular benefits over time.
Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Earlier identification of high coronaryarterydisease (CAD) risk individuals may enable more effective prevention strategies. However, existing 10-year risk frameworks are ineffective at earlier identification.
Individuals with a high genetic risk for coronaryarterydisease (CAD) also have an increased risk of developing dementia, according to a large UK population study published April 4 in Circulation.
Circulation, Volume 150, Issue Suppl_1 , Page A4136459-A4136459, November 12, 2024. Introduction:Patients with Type 2 diabetes mellitus (T2DM) have an increased risk for coronaryarterydisease (CAD) compared to patients without T2DM.
Circulation, Volume 150, Issue Suppl_1 , Page A4144277-A4144277, November 12, 2024. However, the long-term outcomes in patient with an intermediate stenosis received FFR have not yet been investigated comprehensively.Methods:We retrospective included 558 patients underwent both coronaryartery angiography (CAG) and FFR.
Circulation, Volume 150, Issue Suppl_1 , Page A4143220-A4143220, November 12, 2024. We evaluated patterns of evidence-based prescription of SGLT2i and GLP1RA over time and by race in US Veterans with T2D and coronaryarterydisease (CAD).Results:Of
Circulation, Ahead of Print. BACKGROUND:Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, is an actively regulated process that involves complex mechanisms.
Circulation, Ahead of Print. BACKGROUND:We investigated the usefulness of invasive coronary function testing to diagnose the cause of angina in patients with no obstructive coronary arteries.METHODS:Outpatients referred for coronary computed tomography angiography in 3 hospitals in the United Kingdom were prospectively screened.
Circulation, Volume 150, Issue Suppl_1 , Page A4143007-A4143007, November 12, 2024. Background:Myocardial infarction with nonobstructive coronaryarterydisease (MINOCA) is a special syndrome with clear evidence of myocardial ischemia, but no clear stenosis of coronaryartery imaging sign.
Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 442-451, October 1, 2023. Background:Patients with de novo chest pain, referred for evaluation of possible coronaryarterydisease (CAD), frequently have an absence of CAD resulting in millions of tests not having any clinical impact.
variants in the vicinity (300 kb) of theADIPOQgene from a GWAS of circulating adiponectin levels (n=~38,600). Higher genetically-proxied,ADIPOQ-mediated circulating adiponectin levels were associated with lower WMH (IVW =-0.131 per g/ml increase in adiponectin levels; 95% CI: (-0.217) - (-0.044); p=0.003) and CAD (IVW OR 0.93
"This pivotal study was performed in two different international populations which shows that CCTA analyzed with the Cleerly AI-QCT ISCHEMIA device provides an accurate assessment of coronary ischemia,” said James P. Circulation. Earls, MD , Chief Medical Officer of Cleerly. Gulati M, Levy PD, Mukherjee D, et al.
MINOCA: Myocardial Infarction in the Absence of Obstructive CoronaryArteryDisease). Here is my comment on MINOCA: "Non-obstructive coronarydisease" does not necessarily imply "no plaque rupture with thrombus." 2) overlooked obstructive coronarydisease (e.g., What is MINOCA? myocarditis).
FDA Breakthrough Device Designation recognizes novel innovations that demonstrate the potential to provide more effective treatment or diagnosis for life-threatening or irreversibly debilitating diseases. Circulation. For more information: [link] References: 1 Maurer M, Elliott P, Comenzo R, et al. 135(14):1357-1377. 2 Siddiqi O.,
Circulation, Ahead of Print. Using mediation Mendelian randomization, we explored proteomic mediators of the effects of genetically proxied IL-6 signaling on coronaryarterydisease, large artery atherosclerotic stroke, and peripheral arterydisease.
Icosapent ethyl (IPE) treatment may be associated with a numerically lower risk of cardiovascular events, but this reduction did not reach statistical significance in patients with chronic coronaryarterydisease (CAD) and a low ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA) on statin treatment, according to the results of the RESPECT-EPA (..)
Self-reported adherence to cardiovascular medications in patients who have coronaryarterydisease is for the combination of aspirin, beta-blocker and a lipid-lowering agent in surveys.7 Circulation. Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in CoronaryArteryDisease.
Circulation, Volume 150, Issue Suppl_1 , Page A4119169-A4119169, November 12, 2024. The patient showed dramatic improvement and was discharged home on oral medications.Discussion:Treating multi-vessel coronaryarterydisease and CTO is challenging. PCI was successful with the use of the Carlino technique: 0.5
ObjectiveThe present study aimed at evaluating the association between sympathetic nervous system activation (SNS) and the severity of coronaryarterydisease (CAD). SYNTAX I score was calculated based on coronary angiography. Systemic activation of the SNS was estimated through circulating levels of norepinephrine (NE).
mmol/l (130 mg/dl) or below, between 20-50% will already have coronaryarterydisease. As HBA1c increases, even in the normal range, the probability of coronaryarterydisease increases. Circulation. For HBA1c, the trend is similar. Remember, these are all in the ‘normal’ range.
Circulation: Cardiovascular Imaging, Ahead of Print. The clinical spectrum of radiation-induced cardiovascular toxicity is broad, encompassing coronaryarterydisease, myocardial dysfunction, valvular abnormalities, and pericardial disorders.
In preparation for the ABIM Cardiovascular Disease exam, check out the BoardVitals Cardiology Board Review Question Bank and we’ll make sure you’re well versed in the following 13 areas covered on the exam: Multiple-Choice Component Arrhythmias 15% CoronaryArteryDisease 23% Heart Failure and Cardiomyopathy 17% Valvular Disease 15% Pericardial (..)
Circulation, Volume 150, Issue Suppl_1 , Page A4140682-A4140682, November 12, 2024. Patients usually have a normal life expectancy unless other structural heart diseases are present. Introduction:Dextrocardia is a rare congenital condition where the heart's apex points to the right, with an incidence of about 0.01%.
Circulation, Volume 149, Issue 3 , Page 251-266, January 16, 2024. Coronaryartery calcification (CAC) accompanies the development of advanced atherosclerosis.
Circulation: Heart Failure, Ahead of Print. BACKGROUND:Coronary microvascular dysfunction (CMD) is involved in heart failure (HF) onset and progression, independently of HF phenotype and obstructive coronaryarterydisease.
Circulation, Volume 150, Issue Suppl_1 , Page A4122763-A4122763, November 12, 2024. Background:The impact of antianginal therapies on the health status of coronaryarterydisease (CAD) patients who have undergone coronary revascularization has not been extensively researched.
Circulation, Volume 150, Issue Suppl_1 , Page A4141524-A4141524, November 12, 2024. Results::Coronaryarterydisease was the primary indication in 87% of cases. At the end of the program, there was a significant improvement in knowledge of the disease (4.5 p <0.001) and its treatment (4.7 p <0.001).Conclusion:Results
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