Physiologically Speaking

JULY 26, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. Genetics of circadian rhythms and sleep in human health and disease A regular sleep pattern, on the other hand, would mean a consistent 10 p.m.

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

Physiologically Speaking

SEPTEMBER 20, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What physiological mechanisms make moderate to high levels of activity so favorable, especially in our modern environment? This week, I’m sharing one of my favorite articles I’ve ever written.

Exercise 114

Exercise Physiology Blood Pressure Obesity 114

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Together, these data demonstrate that the dynamics of FA flux through LD affects endothelial cell homeostasis and consequently large vessel function during normal physiology and in a chronic disease state.

Atherosclerosis 131

Atherosclerosis Chronic Disease Physiology Circulation 131

Dr. Paddy Barrett

AUGUST 23, 2024

V02 Max V02 Max is a measure of the maximum amount of oxygen your body can use during exercise and is best measured in a specialised sports physiology lab as part of a cardiopulmonary exercise test. Muscle Strength Muscle strength is clearly linked to early mortality and less chronic disease. The relationship is clear.

Exercise 116

Exercise Dementia Cancer Chronic Disease 116

Hypertension Journal

DECEMBER 12, 2023

Homeostasis of fluid and electrolytes is a tightly controlled physiological process. Failure of this process is a hallmark of hypertension, chronic kidney disease, heart failure, and other acute and chronic diseases. Hypertension, Ahead of Print.

Chronic Disease 40

Chronic Disease Kidney Disease Hypertension Physiology 40

Physiologically Speaking

OCTOBER 9, 2024

Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. Physiologically Speaking is a reader-supported publication. LaKe is an ester composed of (S)-lactate and (R)-1,3-butanediol, a precursor to BHB.

Exercise 75

Exercise Physiology Diet Obesity 75

Dr. Paddy Barrett

OCTOBER 24, 2023

Not everyone who meets the criteria for metabolic syndrome will become diabetic, but falling into this category means you share much of the same underlying physiology. But our physiology does not care. 5 Life's Essential 8 and risk of non-communicable chronic diseases: Outcome-wide analyses. We are all too busy.

Diabetes 52

Diabetes Cancer Exercise Cardiovascular Disease 52