Science Daily - Heart Disease

MARCH 6, 2024

More than 70% of American Indian young adults aged 20-39 and 50% of American Indian teens have cholesterol levels or elevated fat in the blood that put them at risk for cardiovascular disease, a new study suggests.

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Cholesterol Heart Attack Heart attacks Plaque 121

Physiologically Speaking

JANUARY 5, 2024

In this 6-month randomized controlled study, twice-weekly HIIT reduced coronary plaque volume, increased aerobic fitness, and improved body composition in adults with stable heart disease, suggesting benefits for cardiovascular disease progression. Does this greater plaque presence put athletes at a greater risk of CVD events?

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Plaque Physiology Exercise Cholesterol 119

DAIC

APRIL 11, 2024

These new findings suggest that people with high-risk plaques that are likely to rupture could benefit from the procedure as a pre-emptive measure rather than waiting for a heart attack or other severe reduction in blood flow to occur. During PCI, an operator inserts a stent into a blocked artery through a catheter in the groin or arm.

Plaque 111

Plaque Heart Attack Heart attacks Coronary Artery Disease 111

Cardiometabolic Health Congress

JANUARY 15, 2025

These cases are particularly challenging because traditional prevention strategies, which target known risks like high LDL cholesterol, hypertension, diabetes, and smoking, may not apply.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

DAIC

APRIL 6, 2024

milla1cf Sat, 04/06/2024 - 18:32 April 6, 2024 — The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at the American College of Cardiology ’s Annual Scientific Session.

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Heart Attack Heart attacks Cholesterol Blood Clot 98

Circulation: Cardiovascular Imaging

JANUARY 11, 2024

BACKGROUND:Recently, it was reported that noncalcified plaque (NCP) volume was an independent predictor for cardiac events. Plaque volume was measured by computed tomography angiography, plaque vulnerability by optical coherence tomography, and the level of coronary inflammation by PCAT attenuation. versus 75.9%;P<0.001),

Plaque 75

Plaque Cardiovascular Imaging Cholesterol Circulation 75

JAMA Cardiology

SEPTEMBER 1, 2024

After the introduction of statins in 1987 and the publication of the landmark Scandinavian Simvastatin Survival Trial in 1996, extraordinarily robust evidence has accumulated demonstrating that lowering levels of low-density lipoprotein cholesterol (LDL-C) is associated with a major reduction in cardiovascular morbidity and mortality.

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Cholesterol Plaque Pharmacology 72

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.

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Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Dr. Paddy Barrett

OCTOBER 4, 2024

Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.

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Heart Disease Plaque Cholesterol Risk Factors 104

Dr. Paddy Barrett

SEPTEMBER 20, 2024

When we say heart disease, what we really mean is plaque in the artery wall. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. Every cholesterol particle has a protein marker called ApoB on its outside.

Heart Disease 111

Heart Disease Cholesterol Atherosclerosis Heart Attack 111

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

This interaction led to increased cytosolic cholesterol in macrophages and changes in expression of lipid metabolism genes consistent with increased cholesterol uptake. This function of LDL uptake is unique to cathelicidins from humans and some primates and was not observed with cathelicidins from mice or rabbits.

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Atherosclerosis Cholesterol Cardiovascular Disease Plaque 117

Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. Journal of the American Heart Association, Ahead of Print.

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Ultrasound Plaque Cholesterol Coronary Artery Disease 40

Know Your Heart

FEBRUARY 20, 2019

Controlling Cholesterol What is cholesterol? Cholesterol is a type of fat. Your body uses cholesterol to make hormones and to build and maintain nerve cells. However, when your body has too much cholesterol, deposits of fat in the blood called plaque form inside blood vessel walls.

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Cholesterol Plaque 40

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

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Coronary Artery Disease Plaque Exercise Heart Attack 105

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. to decode the histological, biochemical, pathological secrets within the atherosclerotic plaques.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

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Risk Factors Heart Disease Heart Attack Heart attacks 111

Journal of the American Heart Association

MARCH 6, 2024

We used carotid ultrasounds to detect plaque at baseline and follow‐up in 2006 to 2009 (median follow‐up=5.5 had low‐density lipoprotein cholesterol ≥160 mg/dL, which is higher than the recommended threshold for lifestyle or medical interventions in young adults of 20 to 39 years old. Lipids were measured after a 12‐hour fast.

Plaque 75

Plaque Cholesterol Ultrasound Risk Factors 75

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease.

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Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Dr. Paddy Barrett

FEBRUARY 7, 2025

By the time you get to age 80, you will almost certainly have evidence of plaque in your coronary arteries - you will have heart disease. Normal Cholesterol Levels. But first, let’s get some facts straight. Over a long enough time frame, pretty much everyone will get heart disease. Heart attacks do. Here are your targets.

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Heart Disease Heart Attack Heart attacks Blood Pressure 107

DAIC

APRIL 6, 2024

The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at ACC.24, HDL cholesterol removes cholesterol from the arteries and carries it to the liver, which then excretes it.

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Heart Attack Heart attacks Research Cholesterol 78

Medical Xpress - Cardiology

FEBRUARY 1, 2024

A research team based at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid and Aarhus University in Denmark has identified an important mechanism that can result in the regression, or shrinkage, of atherosclerotic plaques.

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Cholesterol Plaque Research 69

Science Daily - Stroke

JULY 12, 2023

In a major study, researchers have discovered a link between the levels of certain bacteria living in the gut and coronary atherosclerotic plaques. Such atherosclerotic plaques, which are formed by the build-up of fatty and cholesterol deposits, constitute a major cause of heart attacks.

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Heart attacks Heart Attack Plaque Cholesterol 69

HCPLive

MAY 15, 2024

Michael Blaha, MD, discusses the efficacy and safety of novel targeted therapies for lowering LDL cholesterol and emphasizes the importance of long-term data in building patient confidence in this new treatment option.

Plaque 52

Plaque Cholesterol 52

Cardiovascular Diabetology

JULY 3, 2024

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.

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Cholesterol Diabetes Atherosclerosis Plaque 45

Dr. Paddy Barrett

MAY 3, 2024

What is a normal cholesterol? While it is true that the older you are, the higher the risk of a heart attack, the process of plaque buildup starts early in life. Over half of all ‘healthy’ heart arteries examined before being used for a heart transplant were shown to have evidence of early plaque buildup.

Heart Attack 105

Heart Attack Heart attacks Blood Pressure Risk Factors 105

Medical Xpress - Cardiology

JULY 2, 2024

Vascular plaque. It starts with inflammation. Perhaps your blood pressure has been a little too high for a little too long, putting strain on your blood vessels.

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Heart Attack Heart attacks Cholesterol Blood Pressure 52

AMS Cardiology

JANUARY 21, 2023

We all want to be heart-healthy and ensuring our cholesterol levels are in the normal range is one of the most critical steps. High cholesterol can increase your risk of severe conditions like heart disease and heart attacks. Continue reading to learn four heart-healthy habits that can improve your cholesterol.

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Cholesterol Diet Blood Pressure Heart Attack 40

Dr. S. Venkatesan MD

OCTOBER 7, 2024

Labelling of cholesterol as Good and bad , are immature scientific conclusions. Can any one believe this as truth, that there is little correlation between circulating blood lipids with arterial plaque lipids ? Remember , there is no intravascular war going on between good and bad cholesterol. Final message.

Cholesterol 40

Cholesterol Plaque Atherosclerosis Circulation 40

Stroke Journal

JANUARY 12, 2024

BACKGROUND:Small dense low-density lipoprotein cholesterol (sdLDL-C) particles are more atherogenic than large and intermediate low-density lipoprotein cholesterol (LDL-C) subfractions. Incident carotid plaques and their vulnerability were detected by carotid ultrasound at follow-up (2021). Stroke, Ahead of Print.

Plaque 40

Plaque Cholesterol Ultrasound Risk Factors 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Serum remnant lipoprotein particle cholesterol (RLP-C), which includes very-low density lipoproteins (VLDL) and its lipolytic products, contributes to atherosclerotic plaque formation. Novel methods for estimating RLP-C and VLDL-cholesterol (VLDL-C) from a serum fasting lipid profile (FLP) have been proposed (Figure).1,2,3We

Cholesterol 40

Cholesterol Stroke Strokes Plaque 40

Dr. Paddy Barrett

JUNE 21, 2024

Therefore, if someone presents with an event earlier than this age, they likely have been building up plaque for a considerable period prior to this. He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” You can have normal LDL cholesterol levels and an elevated Lp(a).

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Heart Disease Heart Attack Heart attacks Coronary Artery Disease 87

Journal of the American Heart Association

JANUARY 17, 2025

BackgroundIntracranial atherosclerotic stenosis is a leading cause of ischemic stroke and recurrent events due to plaque instability. Highresolution magnetic resonance imaging identifies plaque enhancement as a key marker of instability. After therapy, stenosis decreased from 75.9% (interquartile range, 69.5%84.8%) P<0.001).

Plaque 40

Plaque Stenosis Cholesterol Stroke 40

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Methods In this study, real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting were used to quantify the expression of Wnt3a, Wnt5a, and Wnt5b in the human coronary plaque, and immunohistochemistry was used to identify sites of local expression.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Stroke Journal

DECEMBER 8, 2023

BACKGROUND:Aortic arch plaques are associated with an increased risk of ischemic stroke in patients with cryptogenic stroke or prior embolic events. Arch plaques were assessed by suprasternal transthoracic echocardiography; plaques ≥4 mm in thickness were classified as large plaques. Stroke, Ahead of Print.

Plaque 40

Plaque Aortic Stroke Strokes 40

Journal of the American Heart Association

NOVEMBER 28, 2023

However, the underlying pathology in different age groups of patients with diabetes has not been studied.Methods and ResultsThe aim of this study was to investigate the plaque characteristics and underlying pathology of acute coronary syndrome in different age groups of patients with or without diabetes in a large cohort. versus 64.8%,P=0.016),

Plaque 40

Plaque Diabetes Cholesterol 40

JAMA Cardiology

MARCH 4, 2025

This is because the test is widely available, fast, highly reproducible, low radiation, directly reflective of total coronary plaque burden, and highly predictive of future atherosclerotic cardiovascular disease (ASCVD) events.

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Plaque Cholesterol Cardiovascular Disease 56