JAMA Cardiology

SEPTEMBER 1, 2024

After the introduction of statins in 1987 and the publication of the landmark Scandinavian Simvastatin Survival Trial in 1996, extraordinarily robust evidence has accumulated demonstrating that lowering levels of low-density lipoprotein cholesterol (LDL-C) is associated with a major reduction in cardiovascular morbidity and mortality.

Cholesterol 72

Cholesterol Plaque Pharmacology 72

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. Journal of the American Heart Association, Ahead of Print.

Ultrasound 56

Ultrasound Plaque Cholesterol Coronary Artery Disease 56

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

This interaction led to increased cytosolic cholesterol in macrophages and changes in expression of lipid metabolism genes consistent with increased cholesterol uptake. This function of LDL uptake is unique to cathelicidins from humans and some primates and was not observed with cathelicidins from mice or rabbits.

Atherosclerosis 122

Atherosclerosis Cholesterol Cardiovascular Disease Plaque 122

Medical Xpress - Cardiology

APRIL 7, 2025

The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, in collaboration with researchers across multiple institutions, has published a new study that challenges the long-held belief that high cholesterol correlates and even directly causes coronary artery disease, or plaque buildup in the arteries in metabolically healthy (..)

Cholesterol 43

Cholesterol Research Coronary Artery Disease Diet 43

Know Your Heart

FEBRUARY 20, 2019

Controlling Cholesterol What is cholesterol? Cholesterol is a type of fat. Your body uses cholesterol to make hormones and to build and maintain nerve cells. However, when your body has too much cholesterol, deposits of fat in the blood called plaque form inside blood vessel walls.

Cholesterol 40

Cholesterol Plaque 40

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 106

Coronary Artery Disease Plaque Exercise Heart Attack 106

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. to decode the histological, biochemical, pathological secrets within the atherosclerotic plaques.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

Risk Factors 112

Risk Factors Heart Disease Heart Attack Heart attacks 112

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Journal of the American Heart Association

MARCH 6, 2024

We used carotid ultrasounds to detect plaque at baseline and follow‐up in 2006 to 2009 (median follow‐up=5.5 had low‐density lipoprotein cholesterol ≥160 mg/dL, which is higher than the recommended threshold for lifestyle or medical interventions in young adults of 20 to 39 years old. Lipids were measured after a 12‐hour fast.

Plaque 75

Plaque Cholesterol Ultrasound Risk Factors 75

Science Daily - Stroke

JULY 12, 2023

In a major study, researchers have discovered a link between the levels of certain bacteria living in the gut and coronary atherosclerotic plaques. Such atherosclerotic plaques, which are formed by the build-up of fatty and cholesterol deposits, constitute a major cause of heart attacks.

Heart Attack 69

Heart Attack Heart attacks Plaque Cholesterol 69

HCPLive

MAY 15, 2024

Michael Blaha, MD, discusses the efficacy and safety of novel targeted therapies for lowering LDL cholesterol and emphasizes the importance of long-term data in building patient confidence in this new treatment option.

Plaque 52

Plaque Cholesterol 52

Cardiovascular Diabetology

JULY 3, 2024

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.

Cholesterol 45

Cholesterol Diabetes Atherosclerosis Plaque 45

Medical Xpress - Cardiology

FEBRUARY 1, 2024

A research team based at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid and Aarhus University in Denmark has identified an important mechanism that can result in the regression, or shrinkage, of atherosclerotic plaques.

Cholesterol 66

Cholesterol Plaque Research 66

Medical Xpress - Cardiology

JULY 2, 2024

Vascular plaque. It starts with inflammation. Perhaps your blood pressure has been a little too high for a little too long, putting strain on your blood vessels.

Heart Attack 52

Heart Attack Heart attacks Cholesterol Blood Pressure 52

AMS Cardiology

JANUARY 21, 2023

We all want to be heart-healthy and ensuring our cholesterol levels are in the normal range is one of the most critical steps. High cholesterol can increase your risk of severe conditions like heart disease and heart attacks. Continue reading to learn four heart-healthy habits that can improve your cholesterol.

Cholesterol 40

Cholesterol Diet Blood Pressure Heart Attack 40

JAMA Cardiology

MARCH 4, 2025

This is because the test is widely available, fast, highly reproducible, low radiation, directly reflective of total coronary plaque burden, and highly predictive of future atherosclerotic cardiovascular disease (ASCVD) events.

Plaque 71

Plaque Cholesterol Cardiovascular Disease 71

DAIC

APRIL 7, 2024

It is well known that high levels of low-density lipoprotein (LDL) cholesterol, known as the “bad” cholesterol, heighten cardiovascular risk. In addition, he said, the reduction in levels of apoB is of interest because this protein is found on all of the lipid particles that contribute to cholesterol buildup in the arteries. “If

Cholesterol 116

Cholesterol Heart Attack Heart attacks Myocardial Infarction 116

Dr. S. Venkatesan MD

OCTOBER 7, 2024

Labelling of cholesterol as Good and bad , are immature scientific conclusions. Can any one believe this as truth, that there is little correlation between circulating blood lipids with arterial plaque lipids ? Remember , there is no intravascular war going on between good and bad cholesterol. Final message.

Cholesterol 40

Cholesterol Plaque Atherosclerosis Circulation 40

Stroke Journal

JANUARY 12, 2024

BACKGROUND:Small dense low-density lipoprotein cholesterol (sdLDL-C) particles are more atherogenic than large and intermediate low-density lipoprotein cholesterol (LDL-C) subfractions. Incident carotid plaques and their vulnerability were detected by carotid ultrasound at follow-up (2021). Stroke, Ahead of Print.

Plaque 40

Plaque Cholesterol Ultrasound Stenosis 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Serum remnant lipoprotein particle cholesterol (RLP-C), which includes very-low density lipoproteins (VLDL) and its lipolytic products, contributes to atherosclerotic plaque formation. Novel methods for estimating RLP-C and VLDL-cholesterol (VLDL-C) from a serum fasting lipid profile (FLP) have been proposed (Figure).1,2,3We

Cholesterol 40

Cholesterol Stroke Strokes Plaque 40

Journal of the American Heart Association

JANUARY 17, 2025

BackgroundIntracranial atherosclerotic stenosis is a leading cause of ischemic stroke and recurrent events due to plaque instability. Highresolution magnetic resonance imaging identifies plaque enhancement as a key marker of instability. After therapy, stenosis decreased from 75.9% (interquartile range, 69.5%84.8%) P<0.001).

Plaque 40

Plaque Stenosis Cholesterol Stroke 40

Journal of the American Heart Association

NOVEMBER 28, 2023

However, the underlying pathology in different age groups of patients with diabetes has not been studied.Methods and ResultsThe aim of this study was to investigate the plaque characteristics and underlying pathology of acute coronary syndrome in different age groups of patients with or without diabetes in a large cohort. versus 64.8%,P=0.016),

Plaque 40

Plaque Diabetes Cholesterol 40

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Methods In this study, real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting were used to quantify the expression of Wnt3a, Wnt5a, and Wnt5b in the human coronary plaque, and immunohistochemistry was used to identify sites of local expression.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Stroke Journal

FEBRUARY 1, 2024

Carotid ultrasound results were divided into two groups based on the presence or absence of plaque. Carotid plaque was observed in 1140 (43.5%) subjects and CACS>0 in 1172 (44.7%) subjects. Carotid plaque was observed in 1140 (43.5%) subjects and CACS>0 in 1172 (44.7%) subjects. 1692 (64.6%) were male.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

CTVS

SEPTEMBER 17, 2024

PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source

Peripheral Arterial Disease 52

Peripheral Arterial Disease Plaque Atherosclerosis Cholesterol 52

Dr. Paddy Barrett

NOVEMBER 8, 2024

Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication. Not zero risk.

Cholesterol 130

Cholesterol Plaque Heart Attack Heart attacks 130

Medical Xpress - Cardiology

FEBRUARY 26, 2025

Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.

Coronary Artery Disease 40

Coronary Artery Disease Heart Disease Plaque Atherosclerosis 40

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. Regarding plaque progression analysis, variation in plaque parameter values was wide, and no difference between groups was observed.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

Circulation

NOVEMBER 11, 2024

The primary outcome was the prevalence of carotid artery plaques assessed by ultrasound. Secondary outcomes included changes in NMR-derived lipoprotein subclasses and their mediation effects on carotid plaque. Fish oil supplementation was significantly associated with reduced prevalence of carotid plaques (P=0.023).

Atherosclerosis 40

Atherosclerosis Diabetes Plaque Cholesterol 40

All About Cardiovascular System and Disorders

APRIL 30, 2024

Plaque regression can be demonstrated by ultrasound evaluation of the carotids which are easily accessible. High density lipoprotein cholesterol in the blood increases with regular exercise. HDL is involved in reverse cholesterol transport from the blood vessels to the liver.

Exercise 52

Exercise Heart Disease Blood Pressure Cholesterol 52

The New England Journal of Medicine

FEBRUARY 12, 2025

Virchow described the inflammatory features of atheromatous plaque in 1858,1 and 55 years later, Anitschkow and Chalatow first showed the presence of lipid-laden macrophages (foam cells) in atheroma in a cholesterol-fed rabbit model.2,3. The role of inflammation in atherothrombosis has been recognized since the mid-19th century.

Plaque 40

Plaque Cholesterol 40

Heart 2023 Conference

MARCH 17, 2023

Atherosclerosis, also called " hardening of the arteries, " occurs when fat, cholesterol and other substances are deposited in the walls of the arteries. These deposits are called plaques. Over time, these plaques can narrow or completely block arteries and cause problems throughout the body. Atherosclerosis is a common disease.

Atherosclerosis 52

Atherosclerosis Exercise Plaque Cholesterol 52

All About Cardiovascular System and Disorders

APRIL 22, 2024

Cholesterol levels go up when thyroid function comes down. This in turn can enhance the chance of plaque build-up in the blood vessels of the heart (coronary arteries). If these clots migrate to the blood vessels of the brain, a stroke may result. Reduced function of the thyroid gland is also associated with heart disease.

Heart Disease 52

Heart Disease Heart Failure Blood Pressure Atrial Fibrillation 52

AMS Cardiology

NOVEMBER 4, 2023

Understanding Peripheral Artery Disease Peripheral artery disease or PAD is a condition in which plaque builds up in the arteries that lead to the legs and feet. A diet rich in fruits, vegetables, whole grains and lean proteins can help control blood pressure, cholesterol levels and weight.

Peripheral Arterial Disease 52

Peripheral Arterial Disease Blood Pressure Diet Exercise 52

Circulation

NOVEMBER 11, 2024

M-MDSCs phenotype switch, atherosclerotic lesion development and plaque phenotype was studiedin vivo.Results:We observed CCR5 elevation on Monocytic-MDSCs in the early phase of atherosclerosis. Additionally, DAPTA reduced the migratory potential, reduced cholesterol uptake and improved the functionality (suppression of T cell) of M-MDSCs.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40