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Cardiovascular Fitness: The Key to Longevity | Golden Age Health Summit 2025

Physiologically Speaking

Learn how VO2 max integrates multiple physiological systems (lungs, heart, blood vessels, mitochondria, and more) and why it’s a stronger predictor of longevity than traditional risk factors like cholesterol or BMI. With compelling data, he reveals how boosting your VO2 max by just 3.5

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Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Regarding blood lipids, there were no changes total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, or apolipoprotein A1 (ApoA1) or apolipoprotein-B (ApoB). HbA1c also didn’t change.

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Physiology Friday #200: Higher Aerobic Fitness is Tied to Slower Biological Aging

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. A few biochemical measures were associated with biological age: higher triglycerides predicted faster age acceleration while higher HDL cholesterol predicted slower age acceleration.

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Physiology Friday #194: Exercise "Prehab" Prevents Muscle Loss during Inactivity

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. A new study in the Journal of Physiology investigated a simple and quick “prehabilitation” strategy for older adults, 1 though the applications can apply to all of us, ragardless of age. The Journal of Physiology.

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Physiology Friday #206: Is Too Much Protein Damaging to Your Arteries?

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Macrophages are unleashed to promote the buildup of plaque and cholesterol in the arteries (atherosclerosis). To receive new posts and support my work, consider becoming a free or paid subscriber.

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Flipped C-Terminal Ends of apoA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs

Circulation

BACKGROUND:Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Despite their very low plasma levels of HDL particles, these subjects had normal CEC.

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Physiology Friday #230: Cutting Sugar vs. Cutting Carbs for Cardiometabolic Health

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. For example, ketogenic diets raise LDL cholesterol, which some people believe is harmful. To receive new posts and support my work, consider becoming a free or paid subscriber. That’s a sweet conclusion.