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Learn how VO2 max integrates multiple physiological systems (lungs, heart, blood vessels, mitochondria, and more) and why it’s a stronger predictor of longevity than traditional risk factors like cholesterol or BMI. With compelling data, he reveals how boosting your VO2 max by just 3.5
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Regarding blood lipids, there were no changes total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, or apolipoprotein A1 (ApoA1) or apolipoprotein-B (ApoB). HbA1c also didn’t change.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. A few biochemical measures were associated with biological age: higher triglycerides predicted faster age acceleration while higher HDL cholesterol predicted slower age acceleration.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. A new study in the Journal of Physiology investigated a simple and quick “prehabilitation” strategy for older adults, 1 though the applications can apply to all of us, ragardless of age. The Journal of Physiology.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Macrophages are unleashed to promote the buildup of plaque and cholesterol in the arteries (atherosclerosis). To receive new posts and support my work, consider becoming a free or paid subscriber.
BACKGROUND:Cholesterol efflux capacity (CEC) predicts cardiovascular disease independently of high-density lipoprotein (HDL) cholesterol levels. Despite their very low plasma levels of HDL particles, these subjects had normal CEC.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. For example, ketogenic diets raise LDL cholesterol, which some people believe is harmful. To receive new posts and support my work, consider becoming a free or paid subscriber. That’s a sweet conclusion.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. ICYMI: I appeared as a guest on Siim Land’s podcast to chat about all things VO2 max. You can watch the YouTube video here. kg in the delayed intake group and by 1.18 kg in the immediate intake group.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. ICYMI: On Wednesday, I published my video interview with Dr. Andrew Koutnik. “The shorter your sleep, the shorter your life.”
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.”
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.”
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post!
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. What if your calendar was the key to living a longer, healthier life? Health and time have always been two sides of the same coin, but we haven’t had the technology to bridge them until now.
10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear.
Statins lower cholesterol. Exercise perturbs our entire physiology, and it’s this disruption of homeostasis, integrative crosstalk, and subsequent adaptations that lead to the immense health benefits achieved through physical activity. For one, drugs target single pathways or risk factors.
LDL is potrayed as villian de-chief of atheroscerlois and CAD.But, LDL of about 100 to 160 mg concentration is in constant circulation, in a smooth manner serving other physiological vascular functions. 15272 LDL receptors, caveolae and cholesterol in endothelial dysfunction: oxLDLs accomplices or victims?
Physiologically Speaking is a reader-supported publication. Cardiovascular Health 🫀 Intermittent fasting can lead to improvements in lipid profiles, including reduced levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides.
While factors like high blood pressure, high cholesterol, obesity, and smoking affect both men and women, certain conditions like diabetes, metabolic syndrome, and mental stress tend to pose a higher risk for women. Hormonal changes, particularly during menopause, also play a significant role, altering women’s cardiovascular health.
Other than being overweight and having an elevated cholesterol she was healthy. The physiologic reason for this — is thought to be the result of momentarily increased circulation from mechanical contraction arising from the "sandwiched in" QRS complex. She was feeling fine prior to the last seven days. There was no chest pain.
In physiological state ,it is amazing to note, how a single layer of endothelial cells is able to withstand a lifetime of vascular stress. After all, please remember much greater men like Abraham Lincoln and Mahatma Gandhi lived a stellar life , in the grand old era when no one knew what was cholesterol and lipids.” 2019.0211. )
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. And we know that stress — both psychological and physiological — is a risk factor for CVD. Our thoughts and our neural activity (which our thoughts are after all) are reflected in our physiology, and vice-versa.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. ICYMI On Wednesday, I published a post discussing the different metabolic effects of the ketogenic diet and exogenous ketones during exercise.
Aster proteins mediate the nonvesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). However, the importance of nonvesicular sterol movement for physiology and pathophysiology in various tissues is incompletely understood.
Not everyone who meets the criteria for metabolic syndrome will become diabetic, but falling into this category means you share much of the same underlying physiology. But our physiology does not care. Subscribe now You have to think of this as a matter of degree. This is about an overall lifestyle approach. Impressive findings.
In mammalian cells cholesterol can be synthesized endogenously or obtained exogenously through lipoprotein uptake. Plasma membrane (PM) is the primary intracellular destination for both sources of cholesterol, and maintaining appropriate membrane cholesterol levels is critical for cellular viability.
After all, most people are convinced that a raised cholesterol level causes heart disease, and there appears to be a vast mountain of data to support this hypothesis. I have spent forty years studying this area, and I am absolutely certain that cholesterol (or LDL Low Density Lipoprotein) does not cause heart disease.
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