Frontiers in Cardiovascular Medicine

JANUARY 28, 2025

After treatment, three-months major adverse cardiovascular events (MACE) were assessed as the primary outcome.

Heart Disease 52

Heart Disease Angina Cholesterol Pharmacology 52

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries. How Do Genetic Factors Work?

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Circulation

JANUARY 27, 2025

METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.

Heart Disease 81

Heart Disease Peripheral Arterial Disease Stroke Strokes 81

Journal of the American Heart Association

MARCH 8, 2024

Lowering low‐density lipoprotein cholesterol (LDL‐C) is a cornerstone of reducing risk for atherosclerotic cardiovascular disease. Long‐term safety and tolerability of inclisiran have been assessed, with studies underway to evaluate the effects of inclisiran on cardiovascular outcomes and to provide additional safety and effectiveness data.

Cholesterol 79

Cholesterol Cardiovascular Disease Article Circulation 79

Dr. Paddy Barrett

NOVEMBER 15, 2024

Normal Cholesterol Levels. The study found that the higher/better a person’s LE8 score was, the less likely each of these three outcomes was to occur. Just the same as you would expect with a blood pressure-lowering or cholesterol-lowering medication. Not smoking. Adequate Sleep. Normal Blood Pressure.

Heart Disease 98

Heart Disease Obesity Blood Pressure Cholesterol 98

Journal of the American Heart Association

FEBRUARY 29, 2024

Adjusted hazard ratios and 95% CIs for ASCVD outcomes according to baseline RvD2 levels were calculated using Cox proportional hazards models. Mediation analysis was used to test the indirect effect of serum cholesterol indicators on the association between RvD2 and ASCVD probability. P<0.001).

Cholesterol 63

Cholesterol Cardiovascular Disease Atherosclerosis Outcomes 63

JAMA Cardiology

JANUARY 16, 2024

This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial investigates if bempedoic acid is associated with a reduction in the total burden of cardiovascular events in patients at high risk for cardiovascular disease.

Cholesterol 98

Cholesterol Cardiovascular Disease Outcomes 98

DAIC

MAY 21, 2024

A new peer-reviewed study published in the Journal of the American Heart Association , JAHA, found that Hello Heart’s digital heart health program was associated with reductions in blood pressure (BP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and weight. statins). . - of their body weight. were female.

Blood Pressure 52

Blood Pressure Cholesterol Risk Factors BMI 52

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome, leading to inflammation and cardiovascular diseases. per 100 person‐years,P=0.01).

Aortic valve 40

Aortic valve Cholesterol Aortic Stenosis 40

Journal of the American Heart Association

FEBRUARY 26, 2025

Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. Intensive control of sdLDLC along with other risk factors should be considered to mitigate PP and improve cardiovascular outcomes. Journal of the American Heart Association, Ahead of Print.

Ultrasound 56

Ultrasound Plaque Cholesterol Coronary Artery Disease 56

American College of Cardiology

JANUARY 22, 2024

The goal of the CLEAR Outcomes trial was to evaluate bempedoic acid compared with placebo among statin-intolerant patients.

Cholesterol 63

Cholesterol Outcomes Article 63

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A12-A12, February 1, 2025.

Cholesterol 40

Cholesterol Outcomes Stroke Strokes 40

MIBHS

MARCH 31, 2025

Raising awareness and taking proactive steps can ensure the best possible outcomes for those at risk of heart-related conditions. Preventing Heart Attacks and Cardiac Arrest Maintaining a healthy lifestyle can reduce the risk of both heart attack and cardiac arrest.

Cardiac Arrest 52

Cardiac Arrest Heart Attack Heart attacks Chest Pain 52

DAIC

MAY 3, 2024

New Study Reveals 65 and Older Population Lowered Blood Pressure, Cholesterol and Weight Using Mobile Technology 2. EMPACT-MI Trial Outcomes Reported at ACC.24: Clinical trials and innovative technology took center stage during the month of April, racking up some record number views.

Blood Pressure 105

Blood Pressure Angioplasty Heart Attack Heart attacks 105

Heart BMJ

OCTOBER 10, 2024

Methods The performance of the CVD microsimulation model, developed using the Cholesterol Treatment Trialists’ Collaboration (CTTC) and UK Biobank cohort, was assessed among participants ≥70 years old at (re)surveys in UK Biobank and the Whitehall II studies.

Cholesterol 94

Cholesterol Cardiovascular Disease Diabetes Outcomes 94

DAIC

APRIL 7, 2024

It is well known that high levels of low-density lipoprotein (LDL) cholesterol, known as the “bad” cholesterol, heighten cardiovascular risk. In addition, he said, the reduction in levels of apoB is of interest because this protein is found on all of the lipid particles that contribute to cholesterol buildup in the arteries. “If

Cholesterol 116

Cholesterol Heart Attack Heart attacks Myocardial Infarction 116

DAIC

APRIL 6, 2024

The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at ACC.24, HDL cholesterol removes cholesterol from the arteries and carries it to the liver, which then excretes it.

Heart Attack 78

Heart Attack Heart attacks Research Cholesterol 78

Nature Reviews - Cardiology

MAY 2, 2024

Nature Reviews Cardiology, Published online: 03 May 2024; doi:10.1038/s41569-024-01031-z In the AEGIS-II trial, infusion of apolipoprotein A-I to increase cholesterol efflux capacity did not improve outcomes in patients with acute myocardial infarction.

Myocardial Infarction 64

Myocardial Infarction Cholesterol Outcomes 64

Cardiometabolic Health Congress

JANUARY 15, 2025

These cases are particularly challenging because traditional prevention strategies, which target known risks like high LDL cholesterol, hypertension, diabetes, and smoking, may not apply. Mortality is higher within 30 days of the event, as demonstrated in survival analyses from the SWEDEHEART registry.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

Circulation

NOVEMBER 6, 2023

Background:Among patients treated with statin therapy to guideline-recommended cholesterol levels, residual inflammatory risk assessed by high-sensitivity C-reactive protein (hsCRP) is at least as strong a predictor of future cardiovascular events as is residual risk assessed by low-density lipoprotein cholesterol (LDLC).

Cholesterol 40

Cholesterol Myocardial Infarction Risk Factors Outcomes 40

Journal of the American Heart Association

FEBRUARY 8, 2025

This analysis evaluated the efficacy and safety of bempedoic acid in people with obesity participating in the CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACLInhibiting Regimen) Outcomes trial.MethodsCLEAR Outcomes randomized 13 970 patients to daily bempedoic acid 180 mg or placebo. and hsCRP of 23.2%

Obesity 40

Obesity Outcomes Cholesterol Myocardial Infarction 40

JAMA Cardiology

JUNE 30, 2022

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

Coronary Artery Disease 40

Coronary Artery Disease Outcomes Cholesterol 40

American College of Cardiology

AUGUST 31, 2024

How do high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) [Lp(a)] levels predict cardiovascular (CV) risk over decades of time in women?

Cholesterol 49

Cholesterol Outcomes Article 49

Frontiers in Cardiovascular Medicine

APRIL 2, 2025

BackgroundThe neutrophil to high-density lipoprotein cholesterol ratio (NHR) has been proposed as a potential marker for predicting cardiovascular events. However, its prognostic role following percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) remains unclear.

Myocardial Infarction 40

Myocardial Infarction Cholesterol STEMI Outcomes 40

Physiologically Speaking

JANUARY 5, 2024

And the more you exercise, the better your outcomes. On the other hand, people who already have CVD or have suffered a CVD event can significantly improve their long-term outcomes by adopting a structured exercise program. One the one hand, participating in aerobic and resistance exercise reduce the incidence of CVD.

Plaque 119

Plaque Physiology Exercise Cholesterol 119

The New England Journal of Medicine

AUGUST 30, 2024

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 European Society of Cardiology annual meeting.

Cholesterol 40

Cholesterol Outcomes Research 40

DAIC

APRIL 11, 2024

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. During PCI, an operator inserts a stent into a blocked artery through a catheter in the groin or arm.

Plaque 111

Plaque Heart Attack Heart attacks Coronary Artery Disease 111

Frontiers in Cardiovascular Medicine

DECEMBER 4, 2024

BackgroundBoth triglyceride-glucose (TyG) index and residual cholesterol (RC) are predictors of stroke; however, to what extent the RC is associated with stroke through TyG index is unclear. The exposure was RC, the mediator was TyG index, and the outcome was stroke which followed up from June, 2011, to June, 2018.

Cholesterol 40

Cholesterol Stroke Strokes Outcomes 40

Cardiometabolic Health Congress

AUGUST 23, 2024

Newly included risk factors— untreated vision loss and high LDL cholesterol —underscore the critical role of these elements in maintaining cognitive health. The Cholesterol Connection Cholesterol’s recognition as a risk factor for dementia marks a pivotal advancement in understanding, preventing, and delaying cognitive decline.

Dementia 52

Dementia Cholesterol Risk Factors CME 52

American College of Cardiology

OCTOBER 21, 2024

What is the relationship between non–high-density lipoprotein cholesterol (non–HDL-C) levels after myocardial infarction (MI) and risk of adverse outcomes?

Myocardial Infarction 45

Myocardial Infarction Cholesterol Outcomes Article 45

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. But they don’t guarantee the outcome. This is the spark that sets the fire. Insulin resistance is the gasoline poured on that spark. For sure. ( They set the odds.

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

DAIC

FEBRUARY 28, 2024

“Untreated risk factors have a larger impact on risk for death following a serious heart event among survivors of childhood cancer relative to the general population, and therefore we shouldn’t just assume that because someone is young they don’t need risk factors like high blood pressure or high cholesterol treated.”

Risk Factors 105

Risk Factors Cancer Cardio Oncology Blood Pressure 105

Frontiers in Cardiovascular Medicine

AUGUST 6, 2024

AimsHistorically, atherosclerotic cardiovascular disease (ASCVD) risk profile mitigation has had a predominant focus on low density lipoprotein cholesterol (LDL-C). This relationship is complicated by the co-existence of low high-density lipoprotein cholesterol.

Cardiovascular Disease 52

Cardiovascular Disease Pharmacology Cholesterol Risk Factors 52

DAIC

MARCH 13, 2024

These data demonstrated a highly significant reduction from baseline in Lp(a) compared to placebo to 36 weeks (primary endpoint), according to a written statement released today on the outcomes. Median percentage reduction in Lp(a) of 90% or greater were observed for both doses at week 36.

Cardiovascular Disease 98

Cardiovascular Disease Risk Factors Cholesterol Heart Attack 98

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Methods and results Mixed-effects meta-regression modeling of stand-alone MACE outcomes was performed, with therapy type, population demographics, baseline and change over time in lipid biomarkers as predictors. In total, 54 studies (270,471 patients) were collected, reporting 15 different single cardiovascular events.

Cholesterol 59

Cholesterol Biomarkers Outcomes 59

DAIC

MAY 7, 2024

However, stroke recovery outcomes aren't fully predicted by damage to the CST, suggesting other factors are at play. This personalized approach could open avenues to improve outcomes after stroke," says Jennifer K. difficulty moving or using their arm for daily tasks), independent of CST damage.

Stroke 105

Stroke Strokes Research Public Health 105

CardiacWire

JULY 31, 2024

Topline results are in from NewAmsterdam Pharma’s BROOKLYN study , showing that obicetrapib safely and effectively reduces LDL cholesterol in patients with heterozygous familial hypercholesterolemia (HeFH) who can’t be effectively treated by current cholesterol drugs.

Cholesterol 59

Cholesterol Blood Pressure Outcomes 59