DAIC

JANUARY 4, 2024

Building on evidence from several studies that found prolonged fasting may be unnecessary, a randomized, controlled trial at a Midwest heart hospital determined that allowing patients to eat a heart-healthy diet before elective cardiac catheterization posed no safety risk, while improving patient satisfaction and overall care.

Diet 105

Diet Critical Care Inpatient Nursing 105

Cardiometabolic Health Congress

APRIL 19, 2024

Addressing an Unmet Need in Pediatric Patients with HeFH Heterozygous familial hypercholesterolemia (HeFH) affects about 1 in 313 people—characterized by dangerously high low-density lipoprotein cholesterol (LDL-C) levels. Untreated, it can trigger early heart disease. Statement from Dr. Mary P.

Pediatrics 52

Pediatrics Diet Cholesterol Cardiovascular Disease 52

Cardiometabolic Health Congress

AUGUST 23, 2024

Updated with the latest research since the 2020 edition, this comprehensive report underscores the potential to prevent or significantly delay dementia by targeting modifiable risk factors. This discovery emphasizes the importance of managing cholesterol levels for cardiovascular health and preserving cognitive function as we age.

Dementia 52

Dementia Cholesterol Risk Factors CME 52

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. This randomised trial used the DASH diet as its intervention, which is a primarily plant-based, low fat and lower-sugar diet.

Coronary Artery Disease 106

Coronary Artery Disease Plaque Exercise Heart attacks 106

Physiologically Speaking

JANUARY 12, 2024

In a new study on 144 older men, having a higher cardiorespiratory fitness (VO2 max) and muscle strength, lower levels of body fat, eating a diet higher in carbohydrates and antioxidants, and having a morning chronotype were associated with a slower rate of DNA-based biological aging. A recent study provides us with some novel insight.

Physiology 124

Physiology BMI Exercise Diet 124

Cardiovascular Diabetology

AUGUST 13, 2024

Methods This study investigated the consequences of cold exposure on the BAT and liver proteomes of an established CMD mouse model based on LDL receptor-deficient (LdlrKO) mice fed a high-fat, high-sucrose, high-cholesterol diet for 16 weeks.

Diet 52

Diet Cholesterol Research 52

Physiologically Speaking

NOVEMBER 8, 2023

Life in the fast lane The allure of fasting is in part due to its accessibility — it requires no special gadgets or diet plans and it’s cost-free. Modern nutrition science is catching up with what some cultures have known for centuries. It also supports blood vessel health and may reduce blood pressure.

Diet 52

Diet Cholesterol Physiology Blood Pressure 52

Circulation

NOVEMBER 11, 2024

Background:The role of immune suppressive microenvironment, promulgated by the presence of Myeloid Derived Suppressor Cells (MDSC) have been the major focus of research delineating the underlying mechanisms of cardiovascular diseases (CVD). Circulation, Volume 150, Issue Suppl_1 , Page A4132968-A4132968, November 12, 2024.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Stroke Journal

FEBRUARY 1, 2024

The American Heart Association’s Life’s Essential 8 (LE8) constitute a research and public health construct capturing key determinants of cardiovascular health. Background:Mounting evidence points to a connection between cardiovascular risk during middle age and brain health later in life.

Outcomes 40

Outcomes Dementia Blood Pressure Public Health 40

Physiologically Speaking

JUNE 28, 2024

But research is still undecided on whether we should embrace the idea of the anabolic window. Though this study is just one data point, it adds to a growing body of research suggesting that total daily protein intake is probably what you should really be worrying about. All of the training sessions were supervised. Timing matters?

Physiology 64

Physiology Exercise Research Outcomes 64

Cardiometabolic Health Congress

JUNE 7, 2024

They highlighted that the non-HDL/HDL ratio is a better predictor of ASCVD and that triglycerides (TG) are a sensitive indicator of diet and exercise, emphasizing the importance of lifestyle factors in lipid management and cardiovascular risk reduction. Rader, MD, FNLA, and Daniel E. Soffer, MD, FNLA , shared key insights.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

Physiologically Speaking

JULY 26, 2024

We talk about the ketogenic diet as a metabolic therapy for type 1 diabetes. ” — Dr. Matthew Walker This statement may seem a bit hyperbolic, but it accurately summarizes most of the available research on sleep and health. Welcome to the Physiology Friday newsletter. “The shorter your sleep, the shorter your life.”

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

Physiologically Speaking

JANUARY 26, 2024

It’s also likely that most people aren’t getting all of the nutrients they need from their diet even if they think they are. The researchers also conducted a meta-analysis using the results of this study and 2 other COSMOS substudies (the results of which I discuss in the next section): COSMOS-Mind and COSMOS-Web.

Physiology 52

Physiology Diet Cardiovascular Disease BMI 52

MIBHS

FEBRUARY 28, 2025

While much attention is given to modifiable risk factors such as diet, exercise, and smoking, the role of genetics in heart disease is equally critical yet less understood by the general public. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

DAIC

JANUARY 22, 2024

Over the next five years, each researcher will receive a total of $1 million in funding from the Association, the world’s leading voluntary organization focused on heart and brain health and research, now celebrating 100 years of lifesaving work. The recipient of the 2024 award are: Joseph Loscalzo , M.D.,

Heart Disease 105

Heart Disease Research Aneurysm Cardiovascular Disease 105

Cardiometabolic Health Congress

JANUARY 15, 2025

Urbanization, increased sedentary lifestyles, and unhealthy diets have fueled this trend. These cases are particularly challenging because traditional prevention strategies, which target known risks like high LDL cholesterol, hypertension, diabetes, and smoking, may not apply.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

Physiologically Speaking

FEBRUARY 23, 2024

High-protein diets are often advocated for building muscle, losing weight, and optimizing body composition. Eating this amount of protein means your diet will comprise about 11% of calories from protein, leaving fat and carbs to fill the gaps. In simpler terms: In mice, a high-protein (and hence high-amino-acid) diet activates mTORC1.

Physiology 111

Physiology Atherosclerosis Diet Cardiovascular Disease 111

DAIC

AUGUST 21, 2024

and a researcher at Columbia University’s Mailman School of Public Health in New York City. In this study, researchers developed a scale to predict heart failure risk specifically in American Indian people, based on data from about 3,000 participants in the Strong Heart Study, an ongoing, federally funded study.

Heart Failure 52

Heart Failure Risk Factors Heart attacks Heart Attack 52

Physiologically Speaking

DECEMBER 15, 2023

Specifically: - HDL cholesterol increases by 2–12 mg/dL - Total cholesterol decreases by 8 mg/dL - Triglycerides decrease by 7–13 mg/dL - LDL cholesterol may decrease by 10–13 mg/dL in adults at high cardiometabolic risk Weight and body composition Here’s where resistance exercise shines.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

DECEMBER 15, 2023

Specifically: - HDL cholesterol increases by 2–12 mg/dL - Total cholesterol decreases by 8 mg/dL - Triglycerides decrease by 7–13 mg/dL - LDL cholesterol may decrease by 10–13 mg/dL in adults at high cardiometabolic risk Weight and body composition Here’s where resistance exercise shines.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

MIBHS

DECEMBER 13, 2024

Research on Erectile Dysfunction Improvement After Bypass Surgery Studies have shown that there is a positive correlation between improved cardiovascular health following bypass surgery and the improvement of penile function. This includes eating a balanced diet, engaging in regular exercise, and quitting smoking.

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Diet Heart Disease Risk Factors 52

Dr. Sanjay Gupta

DECEMBER 19, 2022

Basically she had been to see her GP and because her cholesterol was found to be a little on the higher side, she was being strongly advised by her GP to take a Statin. High Cholesterol is not really a condition unless it impacts on the patient’s quality of life or length of life. This is where data from research studies can help.

Heart attacks 40

Heart attacks Heart Attack Quality of Life Cholesterol 40

Dr. Malcolm Kendrick

JANUARY 12, 2023

There was a time when the pharmaceutical industry was happy to pay doctors, and researchers, directly. First, I want to make it clear that corruption is not a new thing in medical research – although it has greatly worsened – and gone undercover. Key Opinion Leaders are sort of like the avengers of the clinical research world.

Research 52

Research Cancer Innovation Article 52

Journal of the American Heart Association

FEBRUARY 13, 2024

BackgroundHigher scores for the American Heart Association Life's Essential 8 (LE8) metrics, blood pressure, cholesterol, glucose, body mass index, physical activity, smoking, sleep, and diet, are associated with lower risk of chronic disease. Journal of the American Heart Association, Ahead of Print.

Blood Pressure 40

Blood Pressure Education Chronic Disease Diet 40

Dr. Malcolm Kendrick

DECEMBER 5, 2024

Pretty exhaustive research there, Barney. In my opinion, or should I say ‘allegedly’ what actually happened here was that Barney Calman had heard from various cardiology experts that cholesterol and statin ‘deniers’ were causing people to stop taking their drugs. Based on … a fly cover. Sorry, I know the answer to that.

Article 105

Article Cholesterol Public Health Research 105

Physiologically Speaking

MAY 3, 2024

ICYMI On Wednesday, I published a post discussing the different metabolic effects of the ketogenic diet and exogenous ketones during exercise. Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post!

Exercise 95

Exercise Physiology Research Kidney Disease 95

DAIC

MARCH 8, 2024

Food and Drug Administration ( FDA ) has approved an additional indication for Wegovy ( semaglutide ) to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight along with a reduced calorie diet and increased physical activity.

Obesity 111

Obesity Heart Disease Heart attacks Heart Attack 111

Dr. S. Venkatesan MD

JANUARY 8, 2024

10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear.

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2024

Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs.

Cholesterol 52

Cholesterol Diet Atherosclerosis Research 52

Dr. Malcolm Kendrick

OCTOBER 30, 2024

I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. The hypothesis that a raised cholesterol level causes heart disease [atherosclerotic cardiovascular disease (ASCVD)] is possibly the single most powerful idea in medicine. With thousands dying.

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Cholesterol Article Research Diet 145