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10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. They were all healthy with none of them having diabetes, or hypertension, meaning that they were well matched.
BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. P=0.006), especially in diabetic patients (Pearsonr=0.58,P<0.001). P<0.001).
The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.
BackgroundHigh cardiovascular mortality has been reported in young patients with diabetes. Culprit plaque was classified as plaque rupture, plaque erosion, or calcified plaque and stratified into 5 age groups. Plaque characteristics including features of vulnerability were examined by optical coherence tomography.
Introduction:It remains uncertain whether dietary supplementation of marine n-3 polyunsaturated fatty acids (PUFAs) improves atherosclerosis and lipoprotein subclasses in patients with type 2 diabetes (T2D). The primary outcome was the prevalence of carotid artery plaques assessed by ultrasound. day) or low-dose (1.5g/day)
BACKGROUND:Small dense low-density lipoprotein cholesterol (sdLDL-C) particles are more atherogenic than large and intermediate low-density lipoprotein cholesterol (LDL-C) subfractions. Incident carotid plaques and their vulnerability were detected by carotid ultrasound at follow-up (2021). Stroke, Ahead of Print.
Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. Among those, 58% had diabetes, 50% had myocardial infarction, and 91% were in use of statin and aspirin.
PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source
Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication.
High levels of triglycerides and the lipid particles on which they are carried in the blood can contribute to the formation of “plaques” in the arteries that impede blood flow and can lead to heart attacks and strokes. An estimated 1 in 5 U.S. Patients’ average triglyceride level at baseline was about 900 mg/dL.
High cholesterol levels – Elevated levels of bad cholesterol can contribute to plaque buildup in your arteries, increasing the risk of heart disease. Diabetes – People with diabetes are at an increased risk due to the potential damage high blood sugar can cause to blood vessels and nerves.
Understanding Peripheral Artery Disease Peripheral artery disease or PAD is a condition in which plaque builds up in the arteries that lead to the legs and feet. A diet rich in fruits, vegetables, whole grains and lean proteins can help control blood pressure, cholesterol levels and weight.
26th August 2022 And so, after a great deal of faffing about, my article on cardiovascular disease ‘Assessing cardiovascular disease: looking beyond cholesterol’ has been made free to view. Models not based on LDL/cholesterol levels. Writing an article for a medical journal is not that difficult. Helloooo… ever heard of the Internet.
“Cholesterol does not cause heart disease.“ “Cholesterol doesn’t cause heart disease” The argument goes like this. “If cholesterol causes heart disease, why is it that about half of all patients with a heart attack have normal cholesterol? Cholesterol is an essential part of the story.
This imbalance is partly due to limited healthcare access, fewer preventive resources, and challenges in addressing risk factors such as obesity and diabetes. The Global Burden of Disease data (2023) highlights a grim reality: while high-income countries have seen some success in managing CVD, LMICs now account for most CVD-related deaths.
Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.
Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.
When we say heart disease, what we really mean is plaque in the artery wall. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. Every cholesterol particle has a protein marker called ApoB on its outside.
By the time you get to age 80, you will almost certainly have evidence of plaque in your coronary arteries - you will have heart disease. No diabetes or Pre-Diabetes. Normal Cholesterol Levels. But first, let’s get some facts straight. Over a long enough time frame, pretty much everyone will get heart disease.
milla1cf Sat, 04/06/2024 - 18:32 April 6, 2024 — The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at the American College of Cardiology ’s Annual Scientific Session.
Coronary Artery Disease (CAD) CAD, which involves the narrowing or blockage of coronary arteries due to plaque buildup, can reduce blood flow to the heart. Monitor blood pressure and cholesterol levels regularly. Monitor cholesterol levels and manage conditions like diabetes that can strain the heart.
This blockage is often caused by a blood clot or the buildup of plaque in the coronary arteries, which supply the heart with oxygen-rich blood. A heart attack, or myocardial infarction, happens when an artery becomes blocked, reducing blood flow to the heart muscle.
Therefore, if someone presents with an event earlier than this age, they likely have been building up plaque for a considerable period prior to this. He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” The same is true of uncontrolled diabetes or high blood pressure.
What is a normal cholesterol? While it is true that the older you are, the higher the risk of a heart attack, the process of plaque buildup starts early in life. Over half of all ‘healthy’ heart arteries examined before being used for a heart transplant were shown to have evidence of early plaque buildup.
BACKGROUND:Aortic arch plaques are associated with an increased risk of ischemic stroke in patients with cryptogenic stroke or prior embolic events. Arch plaques were assessed by suprasternal transthoracic echocardiography; plaques ≥4 mm in thickness were classified as large plaques. Stroke, Ahead of Print.
The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at ACC.24, HDL cholesterol removes cholesterol from the arteries and carries it to the liver, which then excretes it.
Limit your intake of saturated and trans fats, as they can raise cholesterol levels and increase the risk of heart disease. Smoking is a major risk factor for heart disease as it narrows and damages your blood vessels, leading to plaque buildup. They can assess your blood pressure, cholesterol levels, and other risk factors.
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 4 In the U.S.
PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. This plaque narrows the blood vessels and reduces blood flow to the legs and feet, which may significantly impair physical function, walking performance and quality of life.
In the study, post-menopausal women underwent heart scans to assess their CAC score, a measure of plaque buildup—fat, calcium and other substances—in the heart’s arteries. Researchers analyzed data from 579 post-menopausal women who were taking statins to control their cholesterol and had undergone two CAC scans at least one year apart.
Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies. These findings strengthen the case for broader utilization of finerenone in heart failure management.
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