Journal of the American Heart Association

JANUARY 31, 2024

We examined whether intensive lifestyle intervention (ILI) for weight loss decreased variability of cardiovascular risk factors with a view to additional cardiometabolic benefits.Methods and ResultsThis study was a post hoc secondary analysis of the Look AHEAD (Action for Health in Diabetes) study.

Risk Factors 45

Risk Factors Blood Pressure Cholesterol Diabetes 45

Open Heart

OCTOBER 15, 2024

obese (body mass index≥30 kg/m 2 ) and 53.5% centrally obese (waist circumference≥88 cm for women, ≥102 cm for men). reached the low-density lipoprotein cholesterol target of <2.6 62% of patients with self-reported diabetes mellitus attained the glycated haemoglobin target of <7.0%. Only 37.8%

Blood Pressure 40

Blood Pressure Diabetes Risk Factors Obesity 40

CardiacWire

NOVEMBER 12, 2023

The US obesity management arena gained a major new competitor last week with the FDA approval of Eli Lilly’s Zepbound, giving obese and overweight patients in the US a second (on-label) option beyond Novo Nordisk’s Wegovy. weight reductions among people with T2D in the SURMOUNT-2 trial, and 15% to 20.9%

Obesity 52

Obesity Diabetes Blood Pressure Cholesterol 52

Dr. Paddy Barrett

NOVEMBER 8, 2024

Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication. Not zero risk.

Cholesterol 130

Cholesterol Plaque Heart Attack Heart attacks 130

Stroke Journal

JANUARY 30, 2025

Older adults with obesity and metabolic syndrome may have decreased elimination of the xylitol metabolite xylose, which may explain the higher observed risk of thrombosis and stroke in older adults who consume foods with sugar alcohols. However, multiomics studies of both xylitol metabolites and these miRs in humans have not been done.

Thrombosis 40

Thrombosis Obesity Stroke Strokes 40

Cardiometabolic Health Congress

JUNE 7, 2024

Untangling the Statins and Diabetes Link : Dr. Savitha Subtamaniam explored the incidence of diabetes associated with statin use, noting that the mechanism is unclear. She also highlighted uncertainty regarding whether statins worsen glycemic management in individuals with pre-existing diabetes.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

Frontiers in Cardiovascular Medicine

DECEMBER 5, 2024

Modified low-density lipoproteins (LDL), such as oxidized LDL (oxLDL), small dense LDL (sdLDL), and electronegative LDL [LDL(-)], are capable of triggering the atherogenic process, favoring the subendothelial accumulation of cholesterol and promoting inflammatory, proliferative, and apoptotic processes characteristic of atherosclerotic lesions.

Circulation 40

Circulation Stroke Strokes Atherosclerosis 40

Frontiers in Cardiovascular Medicine

MARCH 11, 2024

Cholesterol is an essential molecule that affects the distribution and proper functioning of this receptor. Case presentation The patient was an obese 72 years old man, past smoker, diagnosed with ischaemic heart disease, type 2 diabetes mellitus and lipid metabolism disorder.

Chronic Disease 45

Chronic Disease Cholesterol Obesity Heart Disease 45

AMS Cardiology

AUGUST 15, 2023

High cholesterol levels – Elevated levels of bad cholesterol can contribute to plaque buildup in your arteries, increasing the risk of heart disease. Obesity and poor diet – Being overweight coupled with other risk factors can lead to heart problems.

Heart Disease 52

Heart Disease Blood Pressure Risk Factors Cholesterol 52

Dr. Paddy Barrett

JANUARY 24, 2025

In the early 1970’s a group of 106 severely obese patients were put on a diet that resulted in an average weight loss of 63 Kg (139 lbs) over about one year 2. In addition to this very aggressive calorie restriction, patients also consumed very little fat, protein, cholesterol, or salt. But Let Me Tell You A Story. Diabetologia.

Diet 52

Diet Obesity Diabetes Cholesterol 52

Journal of the American Heart Association

FEBRUARY 29, 2024

Generalized linear models with Poisson distribution were used to examine the prevalence and prevalence ratios of self‐reported hypertension, diabetes, high cholesterol, physical inactivity, smoking, and overweight/obesity among Asian subgroups compared with US‐born NHW adults. Participants' mean (±SD) age was 49±0.1

Risk Factors 40

Risk Factors Obesity Diabetes Cholesterol 40

Dr. S. Venkatesan MD

JANUARY 21, 2024

(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It is expected to change its shape like a chameleon, while ferrying the cholesterol to liver.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

Dr. Paddy Barrett

AUGUST 16, 2024

Overweight/Obesity. Falling into the class of obesity with a BMI of greater than 30 makes this more likely, but so also does having excess visceral fat deposition with significant metabolic consequences at a BMI less than 30. Weight Loss Potential With Obesity Medications. ” here is what I tell them. The exact same thing.

Obesity 52

Obesity Blood Pressure Diet Exercise 52

Stroke Journal

FEBRUARY 1, 2024

Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. Albumin, B12, total bilirubin, cholesterol, CRP, ferritin, iron, folate, hbA1c, HDL, LDL, hemoglobin, MCV, INR, ALT, triglycerides, and vitamin D were abstracted from health records. 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Dr. Paddy Barrett

FEBRUARY 14, 2025

“Cholesterol does not cause heart disease.“ “Cholesterol doesn’t cause heart disease” The argument goes like this. “If cholesterol causes heart disease, why is it that about half of all patients with a heart attack have normal cholesterol? Cholesterol is an essential part of the story.

Cholesterol 114

Cholesterol Heart Disease Heart Attack Heart attacks 114

Dr. Malcolm Kendrick

AUGUST 26, 2022

26th August 2022 And so, after a great deal of faffing about, my article on cardiovascular disease ‘Assessing cardiovascular disease: looking beyond cholesterol’ has been made free to view. Models not based on LDL/cholesterol levels. Writing an article for a medical journal is not that difficult. Helloooo… ever heard of the Internet.

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Article Plaque 40

Circulation: Cardiovascular Quality & Outcomes

OCTOBER 20, 2023

P=0.13; 82% versus 75%,P=0.95), diabetes (4.8% P=0.84), obesity (35.8% mg/dL,P=0.53), total cholesterol (191.2 mg/dL,P=0.53), total cholesterol (191.2 Inverse probability of treatment weighting analysis showed no significant differences in the burden and control of hypertension (19.3% versus 18.8%,P=0.76; P=0.76; 79.8%

Risk Factors 40

Risk Factors Cardiovascular Disease Cholesterol Biomarkers 40

Physiologically Speaking

AUGUST 9, 2024

On one side, advocates of low-carbohydrate diets argue that cutting carbs, particularly in the form of sugars, is essential for weight management and metabolic health — pointing the rise of insulin resistance, obesity, and type 2 diabetes as evidence that our carbohydrate-laden diets are wreaking havoc on our bodies.

Physiology 69

Physiology Diet Cholesterol Biomarkers 69

MIBHS

DECEMBER 29, 2023

Reducing Risk Factors Exercise helps manage and reduce risk factors associated with heart disease, such as high blood pressure, high cholesterol levels, obesity, and diabetes. This increased efficiency supports overall heart health.

Exercise 52

Exercise Blood Pressure Risk Factors Cardiovascular Disease 52

Physiologically Speaking

JULY 26, 2024

We talk about the ketogenic diet as a metabolic therapy for type 1 diabetes. Dozens if not hundreds of (albeit observational) studies have linked a short sleep duration to a number of health conditions including type 2 diabetes and cardiovascular disease. Welcome to the Physiology Friday newsletter. hours per night.

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

Dr. Paddy Barrett

AUGUST 9, 2024

The 14 Factors Include: Hearing Loss High LDL cholesterol Less Education Traumatic Brain Injury Depression Social Isolation Hypertension Obesity Smoking Excess Alcohol Diabetes Physical Inactivity Air Pollution Visual Loss Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission When You Intervene Matters.

Dementia 116

Dementia Blood Pressure Obesity Cholesterol 116

Dr. Paddy Barrett

NOVEMBER 15, 2024

Normal Cholesterol Levels. No Diabetes or Pre-Diabetes. A study of almost 10,000 adults with obesity (BMI >30) who were evaluated for all LE8 factors and followed for over 7 years can give us some insight 1. Can we take the obesity risk off the table also? Not smoking. Adequate Sleep. Normal Blood Pressure.

Heart Disease 98

Heart Disease Obesity Blood Pressure Cholesterol 98

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries. How Do Genetic Factors Work?

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Cardiometabolic Health Congress

JANUARY 15, 2025

This imbalance is partly due to limited healthcare access, fewer preventive resources, and challenges in addressing risk factors such as obesity and diabetes. For example, the global spread of obesity, particularly among youth, has set the stage for a future pandemic of non-communicable diseases.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

European Journal of Heart Failure

APRIL 6, 2025

During a median follow-up of 12.6years, 349 (4.3%) HF events occurred of which 118 (33.8%) had HF with preserved ejection fraction.

Heart Failure 40

Heart Failure Preserved Ejection Fraction Cholesterol Obesity 40

Dr. Paddy Barrett

DECEMBER 12, 2023

That’s what the field of obesity therapeutics feels like right now. Many pharmacies ran out of stock, and access was often restricted to keep available supplies for diabetics where the drug class had originally been developed. This is no different to how we manage high LDL cholesterol or high blood pressure. N Engl J Med.

Obesity 106

Obesity Heart Attack Heart attacks Diet 106

AMS Cardiology

NOVEMBER 21, 2024

This is because stress causes an increase in cortisol – the primary stress hormone – leading to increases in blood pressure , cholesterol, blood sugar and heart rate. But, sometimes, prolonged stress or sudden, drastic spikes in stress can cause palpitations, trigger heart attacks or increase your risk for heart disease.

Heart Attack 52

Heart Attack Heart attacks Heart Failure Blood Pressure 52

Dr. Paddy Barrett

AUGUST 29, 2023

It all comes down to: What your priorities are What your objectives are Your risk tolerance Your ability to update that risk model Where you draw the line of ‘risk’ equating to ‘causation’ The same is true when it comes to the question of statins ‘causing’ diabetes. What to do? Let’s dive in.

Diabetes 52

Diabetes Risk Factors Heart Attack Heart attacks 52

Dr. Paddy Barrett

SEPTEMBER 20, 2024

The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. Every cholesterol particle has a protein marker called ApoB on its outside. Every cholesterol particle has a protein marker called ApoB on its outside.

Heart Disease 111

Heart Disease Cholesterol Atherosclerosis Heart Attack 111

Dr. Paddy Barrett

MAY 20, 2024

Avoiding diabetes. Maintaining normal LDL cholesterol levels. Avoiding obesity. But we have known for decades that getting these core factors right substantially reduces your risk of heart disease. Being physically active. Not smoking. Maintaining normal blood pressure. Having good nutrition.

Coronary Artery Disease 93

Coronary Artery Disease Heart Disease Blood Pressure Cholesterol 93

Cardiology Update

JANUARY 24, 2024

Growing Global Burden of Cardiometabolic Risks: The 2023 World Obesity Atlas projects a significant rise in global overweight and obesity levels by 2035, leading to a surge in diabetes cases. Strategies promoting healthy aging globally are crucial to mitigate the impact of population aging.

Cardiovascular Disease 119

Cardiovascular Disease Research Blood Pressure Public Health 119

AMS Cardiology

SEPTEMBER 30, 2024

Blood tests : Measure cholesterol levels, blood sugar and other markers of heart health. Regular heart check-ups offer several benefits including: Early detection of heart disease : Many heart conditions such as high blood pressure, high cholesterol and coronary artery disease can be detected early through regular screenings.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Exercise 52

MIBHS

NOVEMBER 15, 2023

Cholesterol Levels Matter Cholesterol is a fatty substance that circulates in the blood. While the body needs cholesterol for various functions, too much of it, especially low-density lipoprotein (LDL) cholesterol, can clog arteries and increase the risk of heart disease.

Blood Pressure 52

Blood Pressure Cholesterol Heart Disease Risk Factors 52

Wellnest

AUGUST 24, 2023

Unhealthy lifestyle habits, genetics, obesity, and other risk factors can contribute to cardiac disease at any stage of life. Myth #4: High cholesterol is the only risk factor for heart disease. While high cholesterol levels can contribute to heart disease, they are not the only factor at play.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Genetic predisposition 52

Circulation

NOVEMBER 11, 2024

The study assessed the prevalence of CVD (heart attack, angina pectoris, coronary heart disease, other heart conditions, or stroke) and LE8 risk factors: insufficient physical activity (PA), nicotine exposure, sleep duration, obesity, physician-diagnosed high cholesterol, diabetes, and hypertension. NHW&amp;6.8%

Risk Factors 40

Risk Factors Cardiovascular Disease Cholesterol Hypertension 40

MIBHS

OCTOBER 31, 2023

Limit your intake of saturated and trans fats, as they can raise cholesterol levels and increase the risk of heart disease. If you’re overweight or obese, making gradual changes to your diet and increasing physical activity can help you shed pounds and reduce the strain on your heart.

Blood Pressure 52

Blood Pressure Heart Disease Diet Risk Factors 52

MIBHS

MAY 15, 2024

While factors like high blood pressure, high cholesterol, obesity, and smoking affect both men and women, certain conditions like diabetes, metabolic syndrome, and mental stress tend to pose a higher risk for women.

Heart Disease 52

Heart Disease Chest Pain Risk Factors Blood Pressure 52