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Dr. Paddy Barrett
NOVEMBER 8, 2024
Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication. Not zero risk.
130 
Dr. Paddy Barrett
FEBRUARY 14, 2025
“Cholesterol does not cause heart disease.“ “Cholesterol doesn’t cause heart disease” The argument goes like this. “If cholesterol causes heart disease, why is it that about half of all patients with a heart attack have normal cholesterol? Cholesterol is an essential part of the story.
113 
Medical Xpress - Cardiology
JANUARY 17, 2024
A new study has hailed camel milk for its ability to lower heart disease risk among diabetics and help in the treatment of dyslipidemia.
132 
HCPLive
JUNE 21, 2024
A first-time trial presented at ADA 2024 found the common cholesterol-lowering drug halts vision loss in patients with diabetic eye disease.
115 
Dr. Paddy Barrett
NOVEMBER 30, 2024
The Defining Risk module includes lessons on: Defining Metabolic Health Cholesterol Principles Understanding Your Cholesterol Panel Advanced Cholesterol Testing Lipoprotein (a) - Lp(a) Insulin Resistance Metabolic Syndrome Pre-Diabetes & Diabetes Assessing Visceral Fat How To Measure Fitness The Importance of Muscle Metrics.
85 
DAIC
APRIL 7, 2024
milla1cf Sun, 04/07/2024 - 18:09 April 7, 2024 — Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or “bad” cholesterol, levels by more than half on average, compared with a placebo.
111 
Dr. Paddy Barrett
JANUARY 2, 2025
The Defining Risk module includes lessons on: Defining Metabolic Health Cholesterol Principles Understanding Your Cholesterol Panel Advanced Cholesterol Testing Lipoprotein (a) - Lp(a) Insulin Resistance Metabolic Syndrome Pre-Diabetes & Diabetes Assessing Visceral Fat How To Measure Fitness The Importance of Muscle Metrics.
86 
Frontiers in Cardiovascular Medicine
FEBRUARY 11, 2025
BackgroundIndividuals diagnosed with type 2 diabetes mellitus (T2DM) commonly exhibit elevated lipid levels and an increased body mass index (BMI). The impact of BMI on the efficacy of statins in reducing lipid levels among diabetic patients remains uncertain.
52 
Frontiers in Cardiovascular Medicine
DECEMBER 9, 2024
BackgroundLow-Density Lipoprotein Cholesterol (LDL-C) is the primary lipid therapy target for coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). Employing Multivariate Cox regression analysis, we assessed the correlation between RLP-C and NTLs progression.
98 
DAIC
APRIL 6, 2024
milla1cf Sat, 04/06/2024 - 18:32 April 6, 2024 — The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at the American College of Cardiology ’s Annual Scientific Session.
98 
Cardiomatics
FEBRUARY 5, 2025
We are proud to share our latest study, conducted with University Hospital Basel, and published in Diabetes Care. These commonly used anti-inflammatory drugs often cause insulin resistance, high cholesterol, and muscle loss. This marks our fourth collaboration, and we are eager to do more! But how does it work?
93 
Dr. Paddy Barrett
NOVEMBER 15, 2024
Normal Cholesterol Levels. No Diabetes or Pre-Diabetes. Just the same as you would expect with a blood pressure-lowering or cholesterol-lowering medication. The Life Essential 8 are a set of factors that significantly influence your risk of heart disease and early death, including: Regular Physical Activity. Not smoking.
JAMA Cardiology
JANUARY 14, 2025
This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholesterol (LDL-C) levels with incident type 2 diabetes risk in adult UK Biobank participants.
Dr. Malcolm Kendrick
DECEMBER 10, 2023
What he looked at was a collection of people on very low carb ketogenic diets who also happened to have extremely high LDL cholesterol. They were all healthy with none of them having diabetes, or hypertension, meaning that they were well matched. In those with the very high cholesterol it had been at that level for at least five years.
144 
Science Daily - Heart Disease
JULY 29, 2024
If current guidelines for cholesterol and high blood pressure treatment remain unchanged, a newly unveiled heart risk calculator would render 16 million people ineligible for preventive therapy.
106 
Science Daily - Heart Disease
NOVEMBER 18, 2024
This new insight into the flow of fats through the body points to new therapeutic targets for mitigating diseases like ASCVD, non-alcoholic fatty liver disease, obesity, diabetes, peripheral neuropathy, and neurodegeneration.
Med Page Today
JUNE 22, 2024
(MedPage Today) -- ORLANDO -- The cholesterol drug fenofibrate reduced progression of early eye disease among diabetes patients, the LENS trial showed. The fibrate reduced progression of early diabetic retinopathy or maculopathy by a relative.
59 
Frontiers in Cardiovascular Medicine
NOVEMBER 19, 2024
BackgroundOne measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovascular disease (CVD) risk. This association remained significant even after further adjustment for single measurements of NHHR.
59 
MIBHS
FEBRUARY 28, 2025
Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries. How Do Genetic Factors Work?
Dr. Paddy Barrett
NOVEMBER 27, 2024
The Defining Risk module includes lessons on: Defining Metabolic Health Cholesterol Principles Understanding Your Cholesterol Panel Advanced Cholesterol Testing Lipoprotein (a) - Lp(a) Insulin Resistance Metabolic Syndrome Pre-Diabetes & Diabetes Assessing Visceral Fat How To Measure Fitness The Importance of Muscle Metrics.
HCPLive
MAY 29, 2024
Michael Blaha, MD, highlights the potential of GLP-1 agonists in lowering LDL cholesterol, triglycerides, and body weight in patients with diabetes, presenting them as an additional option for reducing cardiovascular risk in this patient population.
59 
Cardiovascular Diabetology
OCTOBER 13, 2024
Older general population-based studies found an inverse association between serum HDL-cholesterol and both cardiovascular disease (CVD) events and mortality, but more recent data have suggested a U-shaped rela.
52 
Cardiovascular Diabetology
JANUARY 7, 2025
Remnant cholesterol (remnant-C) contributes to atherosclerotic cardiovascular disease (ASCVD), particularly in individuals with impaired glucose metabolism. Patients with impaired glu.
Cardiovascular Diabetology
JULY 3, 2024
The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.
45 
Open Heart
FEBRUARY 10, 2025
Laboratory predictors (eg, cholesterol and diabetes) had strong HRs, while body mass index in non-laboratory models showed limited effect. Protocol: PROSPERO (CRD42021291936). Results Nine studies (1 238 562 participants, 46 cohorts) identified six unique CVD risk equations. Median c-statistics were 0.74
52 
CardiacWire
MARCH 29, 2024
A new Lancet study brought statins’ diabetes risks back into the headlines, showing that statins do indeed drive significant increases in new diabetes diagnoses, while arguing that statins’ cardiovascular benefits still far outweigh their diabetes risks.
59 
Dr. Paddy Barrett
FEBRUARY 7, 2025
No diabetes or Pre-Diabetes. Normal Cholesterol Levels. If you start in your 20s and 30s and get the following fundamentals right, you are well on course to massively reducing your risk of heart disease and also living longer. Here are your targets. Being physically active. Normal Blood Pressure. Good Nutrition. Normal Weight.
106 
Dr. Paddy Barrett
APRIL 26, 2024
Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. On the far end of that line is type two diabetes. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants.
105 
DAIC
AUGUST 15, 2024
13, 2024 – The traditional lipid panel may not give the full picture of cholesterol-related heart disease risk for many Americans, according to a study led by UT Southwestern Medical Center researchers and published in JAMA Cardiology. Ann Marie Navar, M.D., tim.hodson Thu, 08/15/2024 - 10:32 Aug. population.
105 
Dr. Paddy Barrett
AUGUST 9, 2024
The 14 Factors Include: Hearing Loss High LDL cholesterol Less Education Traumatic Brain Injury Depression Social Isolation Hypertension Obesity Smoking Excess Alcohol Diabetes Physical Inactivity Air Pollution Visual Loss Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission When You Intervene Matters.
115 
Dr. Paddy Barrett
SEPTEMBER 20, 2024
The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. Every cholesterol particle has a protein marker called ApoB on its outside. Every cholesterol particle has a protein marker called ApoB on its outside.
111 
Cardiometabolic Health Congress
JANUARY 15, 2025
This imbalance is partly due to limited healthcare access, fewer preventive resources, and challenges in addressing risk factors such as obesity and diabetes. The Global Burden of Disease data (2023) highlights a grim reality: while high-income countries have seen some success in managing CVD, LMICs now account for most CVD-related deaths.
American Heart News - Heart News
MARCH 26, 2025
Statement Highlights: By age 18, many adolescents have already developed heart disease risk factors, such as high blood pressure, obesity, high cholesterol or Type 2 diabetes, and a growing number of younger adults are experiencing adverse.
MIBHS
MARCH 31, 2025
Seeking emergency medical attention can restore blood flow and prevent further damage. Preventing Heart Attacks and Cardiac Arrest Maintaining a healthy lifestyle can reduce the risk of both heart attack and cardiac arrest.
Dr. Paddy Barrett
OCTOBER 4, 2024
Controlling LDL cholesterol. Let's take a 42-year-old male with an LDL cholesterol of 5.1 mmol/l (197 mg/dl) with normal blood pressure who is a little overweight, does not smoke or have diabetes and has a family history of heart disease. How much would they benefit from going on a cholesterol lowering medication?
104 
Journal of the American Heart Association
FEBRUARY 26, 2025
Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. P=0.006), especially in diabetic patients (Pearsonr=0.58,P<0.001). Journal of the American Heart Association, Ahead of Print. months, PP was found in 65 lesions (44.5%), and mean changes in percent atheroma volume were 4.1%10.2%.
56 
Dr. Paddy Barrett
AUGUST 29, 2023
It all comes down to: What your priorities are What your objectives are Your risk tolerance Your ability to update that risk model Where you draw the line of ‘risk’ equating to ‘causation’ The same is true when it comes to the question of statins ‘causing’ diabetes. What to do? Let’s dive in.
52 
Heart BMJ
OCTOBER 10, 2024
Methods The performance of the CVD microsimulation model, developed using the Cholesterol Treatment Trialists’ Collaboration (CTTC) and UK Biobank cohort, was assessed among participants ≥70 years old at (re)surveys in UK Biobank and the Whitehall II studies.
94 
Circulation
NOVEMBER 11, 2024
Background:Inflammation and cholesterol jointly contribute to cardiovascular disease and mortality. The relative contributions of inflammation and cholesterol to the risk of future cardiovascular events might shift according to pre-existing traits of each individual. female, mean age 46.8 ± 19.7
40 
Cardiovascular Diabetology
NOVEMBER 4, 2024
High-intensity statin is recommended for patients undergoing percutaneous coronary intervention (PCI), and ezetimibe is recommended to be added in patients not achieving low-density lipoprotein cholesterol (LD.
59 
DAIC
FEBRUARY 1, 2024
.** According to the American Diabetes Association, cardiovascular disease (CVD), where the heart and blood vessels are negatively impacted, is the number one cause of death in people living with diabetes, resulting in 2/3 of deaths in people with type 2 diabetes. million have diagnosed diabetes; and 9.7 In addition, 115.9
DAIC
APRIL 6, 2024
The first trial of a novel strategy for removing cholesterol from patients’ arteries did not reduce the risk of death, heart attack or stroke within three months of a prior heart attack, according to research presented at ACC.24, HDL cholesterol removes cholesterol from the arteries and carries it to the liver, which then excretes it.
78 
Dr. Paddy Barrett
JUNE 21, 2024
He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” The same is true of uncontrolled diabetes or high blood pressure. You can have normal LDL cholesterol levels and an elevated Lp(a). FH is a genetic cholesterol disorder present in about 1 in 300 people 3.
Dr. Paddy Barrett
MAY 3, 2024
What is a normal cholesterol? It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. Lp(a) is a genetic cholesterol particle disorder that is present in 10 to 20% of the population. High LDL cholesterol is a risk factor for heart disease.
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