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Live well, think well: Research shows healthy habits tied to brain health

Science Daily - Heart Disease

In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.

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Cholesterol’s Star Role in Dementia Prevention: New Insights from the 2024 Lancet Dementia Report 

Cardiometabolic Health Congress

The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed. Presented by Pamela B. Morris, MD.

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What To Eat To Lose Weight & Maintain Muscle

Dr. Paddy Barrett

Be satiating Low in sugar In a Carbohydrate/Fat Balance that suits your preference and doesn’t drive your LDL cholesterol through the roof. Please go and read every single GLP-1 trial on weight loss (Average 15 kg) and show me where they got everyone to go on an extremely low-carb diet to avoid insulin spikes.

Diet 105
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Abstract DP14: Neuroinflammatory mechanisms linking metabolic syndrome with vascular cognitive impairment

Stroke Journal

Background:PCSK9, a key regulator of cholesterol metabolism, has been implicated in atherosclerosis. However, its potential role in vascular cognitive impairment and dementia (VCID) remains elusive. PCSK9 overexpression was induced via AAV injection, and mice were subjected to either a normal diet or HFD for 4 months.

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Abstract WMP21: Life's Essential 8 and Brain Health Clinical Outcomes in Middle-Aged Adults

Stroke Journal

We excluded participants with stroke, dementia, or late-life depression (LLD) at baseline. The exposure of interest was the LE8 score, a validated tool that captures the LE8 components (blood pressure, glucose, and cholesterol, body mass index, smoking, physical activity, diet, and sleep duration), organized in 3 categories.

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Abstract 10: Enhanced Benefits of the Life's Essential 8 in APOE Epsilon 4 Carriers

Stroke Journal

While the epsilon (ε) 4 variants within theAPOEgene have been extensively investigated as a risk factor for dementia and stroke,APOEε4 carriers have not been thoroughly studied as an at-risk population. Background:Adherence to the American Heart Association's Life’s Essential 8 (LE8) reduces the risk of cardiovascular disease.

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Highlights from The National Lipid Association (NLA) Scientific Sessions 

Cardiometabolic Health Congress

He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia. Ballantyne, MD , emphasized that while fellows may consider prevention “boring,” it is crucial for avoiding resource-intensive late-stage cardiovascular disease (CVD). Ballantyne, MD, FNLA , Robert A.