Remove Cholesterol Remove Coronary Artery Disease Remove Outcomes
article thumbnail

How To Reverse Coronary Artery Disease With Lifestyle Measures

Dr. Paddy Barrett

Reversing or regressing coronary artery disease is possible. You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. Subscribe now 1 Pathophysiology of Coronary Artery Disease.

article thumbnail

The Role of Genetics in Heart Disease: Can You Prevent It?

MIBHS

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. A family history of heart disease often indicates that genetic factors might be at play. Mutations can lead to elevated LDL (bad cholesterol) levels.

article thumbnail

How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Dr. Paddy Barrett

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. Timing Matters.

article thumbnail

Suboptimal Control of Small Dense Low‐Density Lipoprotein Cholesterol Is Associated With Coronary Plaque Progression: An Intravascular Ultrasound Study

Journal of the American Heart Association

Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. Intensive control of sdLDLC along with other risk factors should be considered to mitigate PP and improve cardiovascular outcomes. Journal of the American Heart Association, Ahead of Print.

article thumbnail

Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

DAIC

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. Patients were 64 years old, on average.

Plaque 111
article thumbnail

Association Between HDL-C Levels and Adverse Cardiovascular Outcomes

JAMA Cardiology

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

article thumbnail

Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation

Frontiers in Cardiovascular Medicine

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque 59