Cholesterol, Coronary Artery Disease and Outcomes

How To Reverse Coronary Artery Disease With Lifestyle Measures

Dr. Paddy Barrett

DECEMBER 19, 2023

Reversing or regressing coronary artery disease is possible. You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. Subscribe now 1 Pathophysiology of Coronary Artery Disease.

Coronary Artery Disease

Coronary Artery Disease Plaque Exercise Heart Attack

Association Between HDL-C Levels and Adverse Cardiovascular Outcomes

JAMA Cardiology

JUNE 30, 2022

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

Coronary Artery Disease

Coronary Artery Disease Outcomes Cholesterol

Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease

Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Malnutrition is common in stroke patients and leads to worse outcomes. Body mass index (BMI) is a widely available marker of nutrition status, however studies on BMI and post-ICH outcomes are limited and have conflicting results. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage.

Hemorrhage

Hemorrhage BMI Outcomes Coronary Artery Disease

Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

DAIC

APRIL 11, 2024

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. Patients were 64 years old, on average.

Plaque

Plaque Heart Attack Heart attacks Coronary Artery Disease

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease

Aortic Arch Plaques and the Long-Term Risk of Stroke and Cardiovascular Events in the Statin Era

Stroke Journal

DECEMBER 8, 2023

The primary outcome was ischemic stroke; the secondary outcome was combined cardiovascular events (ischemic stroke, myocardial infarction, and cardiovascular death). The plaque-related risk of outcomes was also analyzed according to the presence of statin treatment.

Plaque

Plaque Aortic Stroke Strokes

Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque

Physiologically Speaking

JANUARY 5, 2024

And the more you exercise, the better your outcomes. On the other hand, people who already have CVD or have suffered a CVD event can significantly improve their long-term outcomes by adopting a structured exercise program. All of the participants had stable coronary artery disease and were on lipid-lowering therapies during the study.

Plaque

Plaque Physiology Exercise Cholesterol

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

MAY 16, 2024

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).

Peripheral Arterial Disease

Peripheral Arterial Disease Exercise Quality of Life Ischemia

The Value Of Lifestyle In Those With An Elevated Lp(a)

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.

Coronary Artery Disease

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease

Does Stress Cause Heart Disease?

Dr. Paddy Barrett

MAY 17, 2024

When stress is included in the risk factor profile for a future heart attack, it comes in third on the list after abnormal cholesterol and smoking 1. Regardless of what is driving the effect, it is clear that experiencing high levels of stress is associated with worse outcomes. 24% increased risk of coronary artery disease.

Heart Disease

Heart Disease Heart Attack Heart attacks Risk Factors

How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. Timing Matters.

Heart Disease

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition

Women with Heart Disease Less Likely to Receive Life-saving Drugs than Men

DAIC

APRIL 29, 2024

Getty Images milla1cf Mon, 04/29/2024 - 13:06 April 29, 2024 — Women with heart disease are less often treated with cholesterol-lowering drugs than men, according to research presented today at ESC Preventive Cardiology 2024 , a scientific congress of the European Society of Cardiology ( ESC ).1 80 years or older).

Heart Disease

Heart Disease Cholesterol Heart Attack Heart attacks

Future Lp(a) Treatment Options

Dr. Paddy Barrett

SEPTEMBER 12, 2023

An elevated Lp(a) is the most common genetic cholesterol disorder impacting 10-20% of the population. Everyone should have an Lp(a) blood test at least once, but this is an absolutely must-do test if you have an early family history of heart disease. Subscribe now 1 ODYSSEY Outcomes Committees and Investigators.

Cholesterol

Cholesterol Coronary Artery Disease Heart Disease Cardiovascular Disease

TIMP-1 in the prognosis of patients who underwent coronary artery bypass surgery: a 12-year follow-up study

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Introduction Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been linked to clinical outcomes in patients with coronary artery disease (CAD). However, the prognostic value of TIMP-1 in patients with CAD who underwent coronary artery bypass grafting (CABG) has not been elucidated.

Coronary Artery Bypass Graft

Coronary Artery Bypass Graft Coronary Artery Disease Myocardial Infarction Cholesterol

7 Heart Disease Risk Factors That Go Unseen

Dr. Paddy Barrett

OCTOBER 10, 2023

Even in those with documented coronary artery disease, less than half were on statin therapy, which has been repeatedly proven to decrease risk in this high-risk group 1. It is genetically mediated, so if you have an early family history of heart disease, this is something to consider 2.

Risk Factors

Risk Factors Heart Disease Blood Pressure Coronary Artery Disease

The First 60 Minutes of a Heart Attack: The Golden Hour

Wellnest

JULY 19, 2023

The accumulation of cholesterol, foam cells, fibrous tissue, and calcium mainly causes the narrowing of coronary arteries. It’s essential for those at risk of coronary artery disease to be aware of the following symptoms. Maintain healthy cholesterol and triglyceride levels. Maintain a healthy weight.

Heart Attack

Heart Attack Heart attacks Blood Pressure Myocardial Infarction

Cardiovascular Update

How To Reverse Coronary Artery Disease With Lifestyle Measures

Association Between HDL-C Levels and Adverse Cardiovascular Outcomes

Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation

Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

Aortic Arch Plaques and the Long-Term Risk of Stroke and Cardiovascular Events in the Statin Era

Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

The Value Of Lifestyle In Those With An Elevated Lp(a)

Does Stress Cause Heart Disease?

How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Women with Heart Disease Less Likely to Receive Life-saving Drugs than Men

Future Lp(a) Treatment Options

TIMP-1 in the prognosis of patients who underwent coronary artery bypass surgery: a 12-year follow-up study

7 Heart Disease Risk Factors That Go Unseen

The First 60 Minutes of a Heart Attack: The Golden Hour

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