Journal of Cardiovascular Pharmacology

MAY 20, 2024

Our objective was to assess whether metformin could mitigate statin-induced adverse effects on PCSK9, thereby improving lipid profiles in patients with coronary artery disease (CAD) but without diabetes.

Coronary Artery Disease 40

Coronary Artery Disease Diabetes Cholesterol 40

American College of Cardiology

SEPTEMBER 23, 2024

Familial hypercholesterolemia (FH), characterized by lifelong elevations in low-density lipoprotein cholesterol (LDL-C), is the most common autosomal-dominant genetic disorder in the world. With appropriate and aggressive treatment this impact can be greatly reduced.

Coronary Artery Disease 56

Coronary Artery Disease Cholesterol Article 56

Dr. Paddy Barrett

SEPTEMBER 20, 2024

The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. ApoB particles crossing the artery wall to cause Atherosclerosis. Every cholesterol particle has a protein marker called ApoB on its outside.

Heart Disease 104

Heart Disease Cholesterol Atherosclerosis Heart Attack 104

Frontiers in Cardiovascular Medicine

NOVEMBER 21, 2024

ObjectiveThis study aims to explore the effect of a case management model that breaks through the temporal and spatial characteristics on the at-home phase II exercise rehabilitation of postoperative patients treated with percutaneous coronary intervention (PCI).MethodsWe

Exercise 59

Exercise Coronary Artery Disease Cholesterol BMI 59

Frontiers in Cardiovascular Medicine

JULY 31, 2024

Recent clinical trials demonstrated that proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors reduce cardiovascular events without affecting systemic inflammation in the patients with coronary artery disease, as determined by high sensitivity C-reactive protein (CRP) levels.

Coronary Artery Disease 52

Coronary Artery Disease Cholesterol Cardiovascular Disease 52

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. Timing Matters.

Heart Disease 95

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 95

Circulation: Genomic and Precision Medicine

JULY 6, 2023

Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 480-482, October 1, 2023.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Atherosclerosis Circulation 40

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

JAMA Cardiology

JUNE 30, 2022

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

Coronary Artery Disease 40

Coronary Artery Disease Outcomes Cholesterol 40

Dr. Paddy Barrett

JUNE 21, 2024

Here is what I DON’T consider as early heart disease. He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” ” Here is what I DO consider as early heart disease. Most of the time, coronary artery disease will be the cause.

Heart Disease 68

Heart Disease Heart Attack Heart attacks Coronary Artery Disease 68

Frontiers in Cardiovascular Medicine

JANUARY 14, 2024

Introduction Statins remain the first-line treatment for secondary prevention of cardiovascular (CV) events, with lowering of low-density lipoprotein cholesterol (LDL-C) being their therapeutic target.

Peripheral Arterial Disease 64

Peripheral Arterial Disease Cardiovascular Disease Cerebrovascular Disease Coronary Artery Disease 64

Dr. Paddy Barrett

OCTOBER 4, 2024

But the goal in this instance is to die after a long and healthy life ‘ with ’ coronary artery disease rather than ‘ from ’ coronary artery disease. However, the chances of dying from heart disease are directly proportional to the amount of plaque in your coronary arteries.

Heart Disease 76

Heart Disease Plaque Cholesterol Risk Factors 76

AMS Cardiology

SEPTEMBER 30, 2024

Blood tests : Measure cholesterol levels, blood sugar and other markers of heart health. Regular heart check-ups offer several benefits including: Early detection of heart disease : Many heart conditions such as high blood pressure, high cholesterol and coronary artery disease can be detected early through regular screenings.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Risk Factors 52

Dr. Paddy Barrett

MAY 20, 2024

Every day we learn something new about the complexity of coronary artery disease. But we have known for decades that getting these core factors right substantially reduces your risk of heart disease. Maintaining normal LDL cholesterol levels. Being physically active. Not smoking. Maintaining normal blood pressure.

Coronary Artery Disease 74

Coronary Artery Disease Heart Disease Blood Pressure Cholesterol 74

DAIC

APRIL 11, 2024

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. Patients were 64 years old, on average.

Plaque 111

Plaque Heart Attack Heart attacks Coronary Artery Disease 111

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies​.

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59

Circulation

NOVEMBER 11, 2024

To induce atherosclerosis, mice were fed high fat diet (HFD) for 6 weeks following partial ligation of left carotid artery in C57BL6 mice. Additionally, DAPTA reduced the migratory potential, reduced cholesterol uptake and improved the functionality (suppression of T cell) of M-MDSCs. 3ng/day for 15 days).M-MDSCs

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. This association remains independent even after adjustment for factors such as statin use or low-density lipoprotein cholesterol (LDL-C) levels.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Dr. Paddy Barrett

FEBRUARY 27, 2024

mmol/l (130 mg/dl) or below, between 20-50% will already have coronary artery disease. As HBA1c increases, even in the normal range, the probability of coronary artery disease increases. For HBA1c, the trend is similar. Remember, these are all in the ‘normal’ range. How LONG has it been abnormal?

Risk Factors 108

Risk Factors Heart Disease Heart Attack Heart attacks 108

Dr. Paddy Barrett

AUGUST 22, 2023

Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease. APO E is also centrally involved in cholesterol metabolism. Here’s how.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Stroke Journal

NOVEMBER 9, 2023

The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease. Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). The median duration of follow-up was 10 years (IQR 3–16). 3.17, P  = 0.006).

Cardiovascular Disease 45

Cardiovascular Disease Peripheral Arterial Disease Cerebrovascular Disease Coronary Artery Disease 45

Dr. Paddy Barrett

SEPTEMBER 12, 2023

An elevated Lp(a) is the most common genetic cholesterol disorder impacting 10-20% of the population. Everyone should have an Lp(a) blood test at least once, but this is an absolutely must-do test if you have an early family history of heart disease. The trial is fully enrolled, but results are still likely several years away.

Cholesterol 52

Cholesterol Coronary Artery Disease Heart Disease Cardiovascular Disease 52

Dr. Paddy Barrett

JANUARY 9, 2024

Understanding your Cholesterol Blood Test Panel. Lifestyle Approaches To Preventing Heart Disease. Understanding the role of Cardiac CT in assessing coronary artery disease. How to use lifestyle measures to reverse coronary artery disease. The Role Of Insulin Resistance.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Cholesterol Cardiovascular Disease 52

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Dr. Paddy Barrett

AUGUST 1, 2023

CT coronary angiography, in addition to a CT CAC, is arguably the best test for estimating whether someone has evidence of coronary artery disease and what that means for their near-term risk of a heart attack. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. N Engl J Med.

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Stroke Journal

FEBRUARY 1, 2024

Albumin, B12, total bilirubin, cholesterol, CRP, ferritin, iron, folate, hbA1c, HDL, LDL, hemoglobin, MCV, INR, ALT, triglycerides, and vitamin D were abstracted from health records. Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

AMS Cardiology

AUGUST 15, 2023

High blood pressure – Hypertension is a significant risk factor for heart disease. High cholesterol levels – Elevated levels of bad cholesterol can contribute to plaque buildup in your arteries, increasing the risk of heart disease. Smoking – Smoking is the most preventable cause of heart disease.

Heart Disease 52

Heart Disease Blood Pressure Risk Factors Cholesterol 52

Dr. S. Venkatesan MD

JANUARY 21, 2024

(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It Lipids in Cardiovascular Disease Eduardo Z. HDL : The untold story ! Cardiovasc.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

Stroke Journal

DECEMBER 8, 2023

4.37]) but not in others; however, participants on statin treatment also had a worse risk profile (higher body mass index, greater frequencies of hypertension, diabetes, and coronary artery disease).CONCLUSIONS:Aortic

Plaque 40

Plaque Aortic Stroke Strokes 40

Dr. Paddy Barrett

JANUARY 23, 2024

By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Subscribe now But are there groups who buck this trend and rarely develop coronary artery disease and, by extension, do not die from it early in life? The answer is yes.

Heart Disease 96

Heart Disease Blood Pressure Dementia Atherosclerosis 96

Physiologically Speaking

JANUARY 5, 2024

Importantly, all of the participants had recently undergone percutaneous coronary intervention (PCI) — a surgical procedure in which a stent is placed in a coronary artery to open up a blockage. All of the participants had stable coronary artery disease and were on lipid-lowering therapies during the study.

Plaque 114

Plaque Physiology Exercise Cholesterol 114

DAIC

JANUARY 25, 2024

mg tablets), together with Caristo Diagnostics , a leading cardiac disease diagnostics company with the novel CaRi-Heart technology to visualize and quantify coronary inflammation, announced today their collaboration to improve awareness and clinical education about the central role of inflammation in coronary artery disease.

Heart Attack 110

Heart Attack Heart attacks Technology Cardiovascular Disease 110

Heart BMJ

NOVEMBER 25, 2024

In multivariable Cox regression analysis, HRs and 95% CIs were calculated per 1 SD increase in strain measure, adjusting for age, sex, systolic blood pressure, low-density lipoprotein cholesterol, smoking, diabetes and family history of premature coronary artery disease. Results During a median follow-up of 1.5 (0.5–4.2)

Myocardial Infarction 52

Myocardial Infarction Coronary Artery Disease Blood Pressure Tricuspid 52

Dr. Paddy Barrett

SEPTEMBER 13, 2024

Low HDL Cholesterol. Even having one of the metabolic syndrome factors increases the risk of dying from heart disease by 73% 4. Having 3 of them while also having type 2 diabetes and existing coronary artery disease increases the risk of dying from heart disease by almost 8 fold. High Blood Pressure.

Risk Factors 95

Risk Factors Heart Disease Dementia Diabetes 95