Circulation: Genomic and Precision Medicine

JULY 6, 2023

Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 480-482, October 1, 2023.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Atherosclerosis Circulation 40

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Dr. Paddy Barrett

JUNE 21, 2024

Here is what I DON’T consider as early heart disease. He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” ” Here is what I DO consider as early heart disease. Most of the time, coronary artery disease will be the cause.

Heart Disease 63

Heart Disease Heart Attack Heart attacks Coronary Artery Disease 63

JAMA Cardiology

JUNE 30, 2022

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

Coronary Artery Disease 40

Coronary Artery Disease Outcomes Cholesterol 40

Frontiers in Cardiovascular Medicine

JANUARY 14, 2024

Introduction Statins remain the first-line treatment for secondary prevention of cardiovascular (CV) events, with lowering of low-density lipoprotein cholesterol (LDL-C) being their therapeutic target.

Peripheral Arterial Disease 64

Peripheral Arterial Disease Cardiovascular Disease Cerebrovascular Disease Coronary Artery Disease 64

Dr. Paddy Barrett

MAY 20, 2024

Every day we learn something new about the complexity of coronary artery disease. But we have known for decades that getting these core factors right substantially reduces your risk of heart disease. Maintaining normal LDL cholesterol levels. Being physically active. Not smoking. Maintaining normal blood pressure.

Coronary Artery Disease 67

Coronary Artery Disease Heart Disease Blood Pressure Cholesterol 67

DAIC

APRIL 11, 2024

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. Patients were 64 years old, on average.

Plaque 111

Plaque Heart Attack Heart attacks Coronary Artery Disease 111

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. This association remains independent even after adjustment for factors such as statin use or low-density lipoprotein cholesterol (LDL-C) levels.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Dr. Paddy Barrett

FEBRUARY 27, 2024

mmol/l (130 mg/dl) or below, between 20-50% will already have coronary artery disease. As HBA1c increases, even in the normal range, the probability of coronary artery disease increases. For HBA1c, the trend is similar. Remember, these are all in the ‘normal’ range. How LONG has it been abnormal?

Risk Factors 103

Risk Factors Heart Disease Heart Attack Heart attacks 103

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Dr. Paddy Barrett

AUGUST 22, 2023

Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease. APO E is also centrally involved in cholesterol metabolism. Here’s how.

Cholesterol 52

Cholesterol Dementia Cardiovascular Disease Coronary Artery Disease 52

Stroke Journal

NOVEMBER 9, 2023

The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease. Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Circulation 52

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). The median duration of follow-up was 10 years (IQR 3–16). 3.17, P  = 0.006).

Cardiovascular Disease 45

Cardiovascular Disease Peripheral Arterial Disease Cerebrovascular Disease Coronary Artery Disease 45

Dr. Paddy Barrett

JANUARY 9, 2024

Understanding your Cholesterol Blood Test Panel. Lifestyle Approaches To Preventing Heart Disease. Understanding the role of Cardiac CT in assessing coronary artery disease. How to use lifestyle measures to reverse coronary artery disease. The Role Of Insulin Resistance.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Cholesterol Cardiovascular Disease 52

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Dr. Paddy Barrett

AUGUST 1, 2023

CT coronary angiography, in addition to a CT CAC, is arguably the best test for estimating whether someone has evidence of coronary artery disease and what that means for their near-term risk of a heart attack. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. N Engl J Med.

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Stroke Journal

FEBRUARY 1, 2024

Albumin, B12, total bilirubin, cholesterol, CRP, ferritin, iron, folate, hbA1c, HDL, LDL, hemoglobin, MCV, INR, ALT, triglycerides, and vitamin D were abstracted from health records. Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Dr. S. Venkatesan MD

JANUARY 21, 2024

(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It Lipids in Cardiovascular Disease Eduardo Z. HDL : The untold story ! Cardiovasc.

Cholesterol 52

Cholesterol Cardiovascular Disease Diabetes Article 52

AMS Cardiology

AUGUST 15, 2023

High blood pressure – Hypertension is a significant risk factor for heart disease. High cholesterol levels – Elevated levels of bad cholesterol can contribute to plaque buildup in your arteries, increasing the risk of heart disease. Smoking – Smoking is the most preventable cause of heart disease.

Heart Disease 52

Heart Disease Blood Pressure Risk Factors Cholesterol 52

Stroke Journal

DECEMBER 8, 2023

4.37]) but not in others; however, participants on statin treatment also had a worse risk profile (higher body mass index, greater frequencies of hypertension, diabetes, and coronary artery disease).CONCLUSIONS:Aortic

Plaque 40

Plaque Aortic Stroke Strokes 40

Physiologically Speaking

JANUARY 5, 2024

Importantly, all of the participants had recently undergone percutaneous coronary intervention (PCI) — a surgical procedure in which a stent is placed in a coronary artery to open up a blockage. All of the participants had stable coronary artery disease and were on lipid-lowering therapies during the study.

Plaque 117

Plaque Physiology Exercise Cholesterol 117

DAIC

JANUARY 25, 2024

mg tablets), together with Caristo Diagnostics , a leading cardiac disease diagnostics company with the novel CaRi-Heart technology to visualize and quantify coronary inflammation, announced today their collaboration to improve awareness and clinical education about the central role of inflammation in coronary artery disease.

Heart Attack 110

Heart Attack Heart attacks Cardiovascular Disease Technology 110

DAIC

MAY 16, 2024

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association. All patients with PAD should be treated with high-intensity statin therapy.

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Quality of Life Ischemia 105

Dr. Paddy Barrett

MAY 17, 2024

When stress is included in the risk factor profile for a future heart attack, it comes in third on the list after abnormal cholesterol and smoking 1. 24% increased risk of coronary artery disease. The link is real. For both acute and chronic stress. No real surprise there.

Heart Disease 80

Heart Disease Heart Attack Heart attacks Risk Factors 80

Wellnest

DECEMBER 21, 2022

Coronary artery disease Excessive cholesterol builds up plaque that blocks the arteries supplying blood to the heart. ECG machine can also help diagnose coronary artery disease. This condition is also called atherosclerosis. Early detection is vital in the treatment of CAD.

Cardiac Arrest 52

Cardiac Arrest Heart Attack Heart attacks Atrial Fibrillation 52

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. Timing Matters.

Heart Disease 87

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 87

DAIC

APRIL 29, 2024

Getty Images milla1cf Mon, 04/29/2024 - 13:06 April 29, 2024 — Women with heart disease are less often treated with cholesterol-lowering drugs than men, according to research presented today at ESC Preventive Cardiology 2024 , a scientific congress of the European Society of Cardiology ( ESC ).1 80 years or older).

Heart Disease 104

Heart Disease Cholesterol Heart Attack Heart attacks 104

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundHigher cholesterol absorption has been reported to be related to a higher incidence of cardiovascular events (CVEs). Baseline and 24‐week follow‐up blood samples were analyzed for cholesterol absorption (eg, campesterol) and synthesis markers (eg, lathosterol). Journal of the American Heart Association, Ahead of Print.

Cholesterol 40

Cholesterol Diet Coronary Artery Disease Risk Factors 40

Dr. Sanjay Gupta

DECEMBER 19, 2022

With time, fat and cholesterol can get trapped in the areas of wear and tear and cause plaque formation. The best way to know if there is plaque in the heart arteries is by a test called CTCA (CT coronary angiography). The plaques can damage us in 2 ways.

Plaque 40

Plaque Heart Rhythm Heart Attack Heart attacks 40

Dr. Paddy Barrett

SEPTEMBER 12, 2023

An elevated Lp(a) is the most common genetic cholesterol disorder impacting 10-20% of the population. Everyone should have an Lp(a) blood test at least once, but this is an absolutely must-do test if you have an early family history of heart disease. The trial is fully enrolled, but results are still likely several years away.

Cholesterol 52

Cholesterol Coronary Artery Disease Heart Disease Cardiovascular Disease 52

Dr. Paddy Barrett

JANUARY 23, 2024

By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Subscribe now But are there groups who buck this trend and rarely develop coronary artery disease and, by extension, do not die from it early in life? The answer is yes.

Heart Disease 89

Heart Disease Blood Pressure Dementia Atherosclerosis 89

Dr. Paddy Barrett

MAY 31, 2024

The most common way to assess the presence and extent of coronary artery disease is with a CT scan, called a CT CAC score or CT Coronary Angiogram. CT Coronary Angiogram. Atherosclerosis in the proximal segment of the vessel. An Owner’s Guide is a great place to start.

Heart Disease 72

Heart Disease Plaque Heart Attack Heart attacks 72

Dr. Paddy Barrett

OCTOBER 17, 2023

Rates of cardiovascular disease have decreased considerably worldwide but, concerningly, have increased in females aged 35 to 54 4. Cholesterol & Menopause Familial hyperlipidemia (FH) is a genetic cholesterol disorder which impacts about 1:200 people. Many of these also increase the risk of cardiovascular disease.

Cholesterol 52

Cholesterol Cardiovascular Disease Heart Attack Heart attacks 52

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Introduction Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been linked to clinical outcomes in patients with coronary artery disease (CAD). However, the prognostic value of TIMP-1 in patients with CAD who underwent coronary artery bypass grafting (CABG) has not been elucidated.

Coronary Artery Bypass Graft 64

Coronary Artery Bypass Graft Coronary Artery Disease Myocardial Infarction Cholesterol 64

Dr. Paddy Barrett

OCTOBER 10, 2023

Even in those with documented coronary artery disease, less than half were on statin therapy, which has been repeatedly proven to decrease risk in this high-risk group 1. It is genetically mediated, so if you have an early family history of heart disease, this is something to consider 2.

Risk Factors 52

Risk Factors Heart Disease Blood Pressure Coronary Artery Disease 52

Wellnest

JULY 19, 2023

The accumulation of cholesterol, foam cells, fibrous tissue, and calcium mainly causes the narrowing of coronary arteries. It’s essential for those at risk of coronary artery disease to be aware of the following symptoms. Maintain healthy cholesterol and triglyceride levels. Maintain a healthy weight.

Heart Attack 52

Heart Attack Heart attacks Blood Pressure Myocardial Infarction 52