Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. In addition, association with LDE nearly abolishes paclitaxel toxicity.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

Circulation: Genomic and Precision Medicine

DECEMBER 3, 2024

BACKGROUND:Genome-wide association studies identified a 20-Kb region of chromosome 8 (8q24.13) associated with plasma lipids, hepatic steatosis, and risk for coronary artery disease. Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004674, December 1, 2024. locus to these traits. locus to these traits.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Circulation 40

Coronary Artery Disease Journal

OCTOBER 15, 2024

Background Coronary artery disease (CAD) is one of the most prevalent cardiovascular diseases where serum lipoprotein oxidation plays a significant role. Results CAD subjects had higher oxHDL/HDL cholesterol (HDL-c) ratio [0.102 (0.0920.112) vs. 0.080 (0.0700.090), P=0.004] and oxLDL/LDL cholesterol (LDL-c) ratio [129.2

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Risk Factors Cardiovascular Disease 40

Cardiovascular Diabetology

JANUARY 21, 2025

Atherogenic index of plasma (AIP), a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol concentrations, is associated with the burden of atherosclerosis.

Coronary Artery Disease 52

Coronary Artery Disease Atherosclerosis Cholesterol Research 52

Journal of the American Heart Association

FEBRUARY 26, 2025

Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein. Journal of the American Heart Association, Ahead of Print. BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture.

Ultrasound 56

Ultrasound Plaque Cholesterol Coronary Artery Disease 56

Coronary Artery Disease Journal

MAY 2, 2024

Background The SYNTAX score is a score that grades the severity and complexity of coronary lesions. In this study, we aimed to investigate the relationship between triglyceride/high-density lipoprotein cholesterol (triglyceride/HDL-C) ratio and SYNTAX scores in patients presenting with non-ST elevation myocardial infarction (NSTEMI).

Cholesterol 40

Cholesterol Coronary Artery Disease Myocardial Infarction STEMI 40

Journal of Cardiovascular Pharmacology

MAY 20, 2024

Our objective was to assess whether metformin could mitigate statin-induced adverse effects on PCSK9, thereby improving lipid profiles in patients with coronary artery disease (CAD) but without diabetes.

Coronary Artery Disease 40

Coronary Artery Disease Diabetes Cholesterol 40

Dr. Paddy Barrett

APRIL 4, 2025

Do you use advanced cholesterol testing? This is all about understanding whether a 'risk factor,’ e.g. High LDL-C cholesterol, has translated into significant ‘disease,’ e.g. coronary artery disease. In general, the more of the disease, the higher the risk. eg ApoB, Lp(a) etc.

Blood Pressure 97

Blood Pressure Exercise Heart Disease Cholesterol 97

Dr. Paddy Barrett

FEBRUARY 27, 2024

mmol/l (130 mg/dl) or below, between 20-50% will already have coronary artery disease. As HBA1c increases, even in the normal range, the probability of coronary artery disease increases. For HBA1c, the trend is similar. Remember, these are all in the ‘normal’ range. How LONG has it been abnormal?

Risk Factors 111

Risk Factors Heart Disease Heart attacks Heart Attack 111

Circulation: Genomic and Precision Medicine

JULY 6, 2023

Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 480-482, October 1, 2023.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Atherosclerosis Circulation 40

Frontiers in Cardiovascular Medicine

JULY 31, 2024

Recent clinical trials demonstrated that proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors reduce cardiovascular events without affecting systemic inflammation in the patients with coronary artery disease, as determined by high sensitivity C-reactive protein (CRP) levels.

Coronary Artery Disease 52

Coronary Artery Disease Cholesterol Cardiovascular Disease 52

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Medical Xpress - Cardiology

FEBRUARY 26, 2025

Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world.

Coronary Artery Disease 40

Coronary Artery Disease Heart Disease Plaque Atherosclerosis 40

JAMA Cardiology

JUNE 30, 2022

This cohort study investigates the association between very high high-density lipoprotein cholesterol (HDL-C) level and outcomes in patients with coronary artery disease.

Coronary Artery Disease 40

Coronary Artery Disease Outcomes Cholesterol 40

Physiologically Speaking

JANUARY 5, 2024

Importantly, all of the participants had recently undergone percutaneous coronary intervention (PCI) — a surgical procedure in which a stent is placed in a coronary artery to open up a blockage. All of the participants had stable coronary artery disease and were on lipid-lowering therapies during the study.

Plaque 119

Plaque Physiology Exercise Cholesterol 119

Coronary Artery Disease Journal

NOVEMBER 14, 2024

Background Lipoprotein(a) [Lp(a)] is an independent, causal risk factor for cardiovascular disease. However, it is still unclear whether controlling low-density lipoprotein cholesterol (LDL-C) to optimal levels can attenuate cardiovascular risk mediated by elevated Lp(a), especially in the setting of secondary prevention.

Cholesterol 40

Cholesterol Risk Factors Cardiovascular Disease Outcomes 40

Dr. Paddy Barrett

AUGUST 22, 2023

Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease. APO E is also centrally involved in cholesterol metabolism. Here’s how.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Journal of the American Heart Association

APRIL 16, 2025

BackgroundIn the SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) trial, atorvastatin (80 mg per day) was compared with placebo in patients with recent stroke or transient ischemic attack and no known coronary artery disease. Journal of the American Heart Association, Ahead of Print.

Strokes 40

Strokes Stroke Coronary Artery Disease Cholesterol 40

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Dr. Paddy Barrett

SEPTEMBER 12, 2023

An elevated Lp(a) is the most common genetic cholesterol disorder impacting 10-20% of the population. Everyone should have an Lp(a) blood test at least once, but this is an absolutely must-do test if you have an early family history of heart disease. The trial is fully enrolled, but results are still likely several years away.

Cholesterol 52

Cholesterol Coronary Artery Disease Heart Disease Cardiovascular Disease 52

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). The median duration of follow-up was 10 years (IQR 3–16). 3.17, P  = 0.006).

Cardiovascular Disease 45

Cardiovascular Disease Peripheral Arterial Disease Coronary Artery Disease Cerebrovascular Disease 45

Stroke Journal

NOVEMBER 9, 2023

The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease. Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023.

Strokes 40

Strokes Stroke Atherosclerosis Coronary Artery Disease 40

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. This association remains independent even after adjustment for factors such as statin use or low-density lipoprotein cholesterol (LDL-C) levels.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

AMS Cardiology

AUGUST 15, 2023

High blood pressure – Hypertension is a significant risk factor for heart disease. High cholesterol levels – Elevated levels of bad cholesterol can contribute to plaque buildup in your arteries, increasing the risk of heart disease. Smoking – Smoking is the most preventable cause of heart disease.

Heart Disease 52

Heart Disease Blood Pressure Risk Factors Cholesterol 52

Dr. Paddy Barrett

JANUARY 9, 2024

Understanding your Cholesterol Blood Test Panel. Lifestyle Approaches To Preventing Heart Disease. Understanding the role of Cardiac CT in assessing coronary artery disease. How to use lifestyle measures to reverse coronary artery disease. The Role Of Insulin Resistance.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Cholesterol Cardiovascular Disease 52

Dr. S. Venkatesan MD

JANUARY 21, 2024

(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It Lipids in Cardiovascular Disease Eduardo Z. HDL : The untold story ! Cardiovasc.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

Coronary Artery Disease Journal

DECEMBER 1, 2024

The results showed that compared with the control group, PCSK9 inhibitors significantly reduced low-density lipoprotein cholesterol (WMD=1.24mmol/L, 95% confidence interval (CI): 1.28 to 1.20), total cholesterol, triglycerides, and Lp(a) levels while increasing high-density lipoprotein cholesterol levels.

Heart Disease 40

Heart Disease Cholesterol Myocardial Infarction Atherosclerosis 40

Circulation

NOVEMBER 11, 2024

To induce atherosclerosis, mice were fed high fat diet (HFD) for 6 weeks following partial ligation of left carotid artery in C57BL6 mice. Additionally, DAPTA reduced the migratory potential, reduced cholesterol uptake and improved the functionality (suppression of T cell) of M-MDSCs. 3ng/day for 15 days).M-MDSCs

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Stroke Journal

FEBRUARY 1, 2024

Albumin, B12, total bilirubin, cholesterol, CRP, ferritin, iron, folate, hbA1c, HDL, LDL, hemoglobin, MCV, INR, ALT, triglycerides, and vitamin D were abstracted from health records. Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Dr. Paddy Barrett

DECEMBER 27, 2024

Non-HDL Cholesterol There is no ‘Good’ cholesterol on a standard cholesterol blood test. There really is only bad cholesterol. The relationship is simple—higher cholesterol for longer increases your risk of coronary artery disease 4. What is your Non-HDL cholesterol?

Coronary Artery Disease 103

Coronary Artery Disease Blood Pressure Cholesterol Heart Disease 103

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. A family history of heart disease often indicates that genetic factors might be at play. Mutations can lead to elevated LDL (bad cholesterol) levels.

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

DAIC

MARCH 31, 2025

mg reduces the risk of major adverse cardiovascular events (MACE) and supports its use in the treatment of cardiovascular disease. mg improved several measures of plaque volume changes over a period of 12 months in patients with stable coronary artery disease, Dr. Budoff continued.

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

Dr. Paddy Barrett

SEPTEMBER 20, 2024

The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. ApoB particles crossing the artery wall to cause Atherosclerosis. Every cholesterol particle has a protein marker called ApoB on its outside.

Heart Disease 111

Heart Disease Cholesterol Atherosclerosis Heart attacks 111

MIBHS

OCTOBER 31, 2024

Heart Valve Disease If one or more heart valves are not functioning correctly, it can cause blood to flow backward, putting extra pressure on the heart, which may cause it to expand to compensate for the inefficiency. Monitor blood pressure and cholesterol levels regularly. Avoid smoking and limit alcohol intake.

Blood Pressure 52

Blood Pressure Blood Clot Heart Valves Heart Rhythm 52

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. Timing Matters.

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

DAIC

APRIL 11, 2024

Plaques that build up in the heart’s arteries contain fats, cholesterol and other substances; most heart attacks and serious cardiac events occur when pieces of such plaques break off and travel through the blood vessel, causing a blockage. Patients were 64 years old, on average.

Plaque 111

Plaque Heart attacks Heart Attack Coronary Artery Disease 111