Circulation

AUGUST 25, 2024

Circulation, Volume 150, Issue 9 , Page 724-735, August 27, 2024. Familial hypercholesterolemia (FH) is a genetic disease that leads to elevated low-density lipoprotein cholesterol levels and risk of coronary heart disease. DNA- and RNA-based therapeutics have the potential to transform the care of patients with FH.

Cholesterol 85

Cholesterol Heart Disease Circulation 85

Nature Reviews - Cardiology

MARCH 27, 2024

Nature Reviews Cardiology, Published online: 28 March 2024; doi:10.1038/s41569-024-01021-1 A new study identifies a hormone that is secreted by the gut in response to cholesterol absorption and can inhibit cholesterol synthesis in the liver, which prevents an increase in circulating cholesterol levels.

Cholesterol 40

Cholesterol Circulation 40

American College of Cardiology

APRIL 1, 2025

Mixed dyslipidemia is characterized by elevated concentrations of circulating triglycerides and low-density lipoprotein cholesterol [LDL-C]).

Cholesterol 66

Cholesterol Circulation Article 66

Dr. S. Venkatesan MD

OCTOBER 7, 2024

Labelling of cholesterol as Good and bad , are immature scientific conclusions. Can any one believe this as truth, that there is little correlation between circulating blood lipids with arterial plaque lipids ? Remember , there is no intravascular war going on between good and bad cholesterol. Final message.

Cholesterol 40

Cholesterol Plaque Atherosclerosis Circulation 40

Frontiers in Cardiovascular Medicine

DECEMBER 5, 2024

Modified low-density lipoproteins (LDL), such as oxidized LDL (oxLDL), small dense LDL (sdLDL), and electronegative LDL [LDL(-)], are capable of triggering the atherogenic process, favoring the subendothelial accumulation of cholesterol and promoting inflammatory, proliferative, and apoptotic processes characteristic of atherosclerotic lesions.

Circulation 40

Circulation Stroke Strokes Atherosclerosis 40

Circulation: Cardiovascular Imaging

NOVEMBER 20, 2023

Circulation: Cardiovascular Imaging, Volume 16, Issue 11 , Page e015589, November 1, 2023. BACKGROUND:Recent studies have shown that remnant cholesterol (RC) is associated with incident heart failure; however, its association with left ventricular (LV) structure and function is unclear.

Cholesterol 40

Cholesterol Cardiovascular Imaging Heart Failure Circulation 40

Circulation: Cardiovascular Imaging

NOVEMBER 20, 2023

Circulation: Cardiovascular Imaging, Volume 16, Issue 11 , Page e016110, November 1, 2023.

Cholesterol 40

Cholesterol Cardiovascular Imaging Circulation 40

CTVS

SEPTEMBER 17, 2024

PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source

Peripheral Arterial Disease 52

Peripheral Arterial Disease Plaque Atherosclerosis Cholesterol 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4125511-A4125511, November 12, 2024. Background:Serum lipids and ratios are known to be associated with cardiovascular disease (CVD). However, studies on NHHR and the association with arterial stiffness in the US population have not been reported.

Cholesterol 40

Cholesterol Atherosclerosis Cardiovascular Disease Hypertension 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A12-A12, February 1, 2025.

Cholesterol 40

Cholesterol Outcomes Stroke Strokes 40

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Circulation: Genomic and Precision Medicine

JULY 6, 2023

Circulation: Genomic and Precision Medicine, Volume 16, Issue 5 , Page 480-482, October 1, 2023.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Atherosclerosis Circulation 40

Circulation

JANUARY 24, 2024

Circulation, Ahead of Print.

Heart Disease 81

Heart Disease Stroke Strokes Peripheral Arterial Disease 81

Dr. Paddy Barrett

NOVEMBER 7, 2023

The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. Each of these particles contains varying amounts of LDL cholesterol (CE) and triglycerides INSIDE the particle. CE = Cholesterol Ester. Share But what about LDL cholesterol? TG = Triglycerides.

Cholesterol 52

Cholesterol Atherosclerosis Stenosis Aortic 52

Circulation: Cardiovascular Imaging

JANUARY 11, 2024

Circulation: Cardiovascular Imaging, Ahead of Print. P<0.001), and cholesterol crystal (42.0% BACKGROUND:Recently, it was reported that noncalcified plaque (NCP) volume was an independent predictor for cardiac events. versus 75.9%;P<0.001), P<0.001), thin-cap fibroatheroma (38.1% versus 20.7%;P<0.001),

Plaque 75

Plaque Cardiovascular Imaging Cholesterol Circulation 75

Dr. Paddy Barrett

FEBRUARY 27, 2024

‘Normal’ levels of risk factors such as blood pressure, cholesterol or blood glucose levels are often FAR from optimal. This is why a female who develops high LDL cholesterol much later in life is at far less risk than a female who has had high LDL cholesterol ALL of her life. Circulation. J Am Coll Cardiol.

Risk Factors 111

Risk Factors Heart Disease Heart attacks Heart Attack 111

Dr. Paddy Barrett

AUGUST 22, 2023

Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease. APO E is also centrally involved in cholesterol metabolism. Here’s how. What to do?

Cholesterol 52

Cholesterol Dementia Cardiovascular Disease Coronary Artery Disease 52

The British Journal of Cardiology

AUGUST 1, 2024

Raised lipoprotein(a) (Lp[a]) cholesterol is highly prevalent affecting 1 in 5 individuals and is also frequently associated with the inherited condition familial hypercholesterolaemia (FH).

Peripheral Arterial Disease 40

Peripheral Arterial Disease Risk Factors Cholesterol Cardiovascular Disease 40

GEMMS

NOVEMBER 22, 2023

Factors such as smoking, high blood pressure, high cholesterol levels, obesity, and a sedentary lifestyle significantly increase the risk of developing cardiovascular disease. Engaging in activities such as running, swimming, or cycling helps strengthen the heart, increase lung capacity, and improve blood circulation.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Frontiers in Cardiovascular Medicine

JULY 17, 2024

Flow cytometry was performed to characterize baseline circulating M1- and M2-macrophages and monocytes. BackgroundSome clinical dyslipidemia cases do not respond to statins, known as statin-resistant familial hypercholesterolemia (SR-FH), in which patients are under a high cardiovascular risk despite statin therapy.

Cholesterol 59

Cholesterol Cardiovascular Disease Heart Disease Circulation 59

Open Heart

DECEMBER 13, 2022

Objective The reduction in circulating low-density lipoprotein cholesterol (LDL-c) is the primary aim of lipid-lowering therapies as a method of atherosclerotic cardiovascular disease risk reduction. mmol/L and total cholesterol from 5.7±1.3 Data on adverse events were also recorded. mmol/L by 48.6% mmol/L by 33.3%

Cholesterol 52

Cholesterol Cardiovascular Disease Circulation 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147134-A4147134, November 12, 2024. Introduction:Elevated LDL cholesterol is linked to microvascular injury and adverse cardiac events in STEMI patients. Statins, or HMG CoA reductase inhibitors, lower LDL levels and reduce cardiovascular risk. and an odds ratio (OR) of 0.54

STEMI 40

STEMI Cholesterol Myocardial Infarction Document 40

Cardiometabolic Health Congress

APRIL 19, 2024

Addressing an Unmet Need in Pediatric Patients with HeFH Heterozygous familial hypercholesterolemia (HeFH) affects about 1 in 313 people—characterized by dangerously high low-density lipoprotein cholesterol (LDL-C) levels. Untreated, it can trigger early heart disease.

Pediatrics 52

Pediatrics Diet Cholesterol Cardiovascular Disease 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142898-A4142898, November 12, 2024. High-dose fish oil intervention significantly reduced remnant cholesterol, LDL-1-triglycerides (TG), HDL-4-TG, and HDL-3-TG, which largely mediated the anti-atherosclerotic effects. day) or low-dose (1.5g/day)

Atherosclerosis 40

Atherosclerosis Diabetes Plaque Cholesterol 40

Circulation

OCTOBER 20, 2023

Circulation, Ahead of Print. BACKGROUND:Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels due to profoundly defective LDLR (LDL receptor) function.

Pediatrics 40

Pediatrics Cholesterol Atherosclerosis Circulation 40

Circulation

JANUARY 23, 2024

Circulation, Ahead of Print. High-cholesterol diet–fed ApoE–/–mice with AVCAPIR knockout were used to examine the role of AVCAPIR in aortic valve calcification (AVC). BACKGROUND:Calcification of the aortic valve leads to increased leaflet stiffness and consequently results in the development of calcific aortic valve disease (CAVD).

Aortic valve 45

Aortic valve Aortic Diet Cholesterol 45

MIBHS

JUNE 28, 2024

Exercise helps strengthen your heart muscle, improves circulation, and lowers blood pressure and cholesterol levels, all of which are crucial for maintaining optimal cardiac health. Schedule regular appointments with your healthcare provider to have your blood pressure, cholesterol levels, and other cardiac risk factors checked.

Blood Pressure 52

Blood Pressure Diet Heart Disease Cholesterol 52

Dr. S. Venkatesan MD

JANUARY 21, 2024

(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It is expected to change its shape like a chameleon, while ferrying the cholesterol to liver.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4143314-A4143314, November 12, 2024. As part of the program, VA sites work with an AHA QI Consultant develop and deploy a local quality improvement plan to help overcome site specific barriers preventing Veterans from achieving optimal cholesterol levels.At

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Heart Failure Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141400-A4141400, November 12, 2024. They contain dietary triglycerides, cholesterols, and apolipoproteins. Introduction:Chylomicrons are major lipid fuel for cells. In the intestine, apolipoprotein C-III (apoC-III) is produced during fat feeding, and secreted onto chylomicrons.

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Atherosclerosis Circulation 40

Circulation

OCTOBER 18, 2023

Circulation, Ahead of Print. BACKGROUND:Homozygous familial hypercholesterolemia is a genetic disease characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular events.

Cholesterol 40

Cholesterol Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147625-A4147625, November 12, 2024. CMS was defined as having ≥3 of five CMS components: large waist circumference, HBP, elevated triglycerides, elevated glucose, and low HDL-cholesterol. Background:Cardiometabolic syndrome (CMS) poses a significant public health concern.

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CMS Public Health Cholesterol Circulation 45

AMS Cardiology

NOVEMBER 4, 2023

Exercise helps improve blood circulation, strengthen the heart and manage weight—all of which can help reduce the risk of PAD. A diet rich in fruits, vegetables, whole grains and lean proteins can help control blood pressure, cholesterol levels and weight. Early detection is key to effective treatment and management.

Peripheral Arterial Disease 52

Peripheral Arterial Disease Blood Pressure Diet Exercise 52

Circulation: Genomic and Precision Medicine

DECEMBER 3, 2024

Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004674, December 1, 2024. Enrichment analyses identified patterns consistent with impaired metabolic functions, including reduced triglyceride and cholesterol handling ability. locus to these traits.

Coronary Artery Disease 40

Coronary Artery Disease Cholesterol Circulation 40

Stroke Journal

JANUARY 30, 2025

In time course experiments on C57BL/6 mice (1d, 3d and 7d post-MCAO), the same technique was performed using Staph A pHrodo bioparticles, BODIPY, LipiM and Bodipy-cholesterol probes to explore changes in neutral lipid level, lipid uptake, and phagocytic activity of leukocytes.

Stroke 40

Stroke Strokes Cholesterol Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4143445-A4143445, November 12, 2024. Introduction:Maintaining a heart-healthy lifestyle is crucial for good cardiovascular health. However, the moderating effects of age and gender on the relationship of diet quality, smoking status, and exercise to cardiovascular health are unknown.

Diet 40

Diet Exercise Blood Pressure Cholesterol 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4139995-A4139995, November 12, 2024. Patients without data on C-reactive protein and high-density lipoprotein cholesterol and those who had a history of coronary artery bypass grafting and stenting in the left anterior descending artery were excluded. Recently, Rinaldi et al.

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Coronary Artery Bypass Graft Chest Pain Angina Cholesterol 40