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Introduction Statins remain the first-line treatment for secondary prevention of cardiovascular (CV) events, with lowering of low-density lipoprotein cholesterol (LDL-C) being their therapeutic target. Recurrent stroke occurs in up to 19% of patients seven years after a first cerebrovascular event.
Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). The median duration of follow-up was 10 years (IQR 3–16). 3.17, P = 0.006).
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovasculardisease, and peripheral vascular disease (inclusive of aortic aneurysm).3
Objective Atherosclerosis is a significant cause of cardiovascular and cerebrovasculardiseases, with a greater impact on men than women. Dietary antioxidant intake is inversely related to the risk of atherosclerosis development. Associations and interactions between variables were assessed using linear regression analyses.
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