article thumbnail

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

Frontiers in Cardiovascular Medicine

Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the underlying molecular mechanisms.

article thumbnail

FDA Accepts, Grants Priority Review Designation for Bayer's msNRA for Patients with Heart Failure

DAIC

live with HF, 2 a complex clinical syndrome with symptoms and signs that result from any structural or functional impairment of ventricular filling or ejection of blood. 2 Most are balancing multiple comorbidities, such as obesity, diabetes, hypertension and chronic kidney disease (CKD). 4 Approximately 6.7 million adults in the U.S.

article thumbnail

Extracoronary Calcification Increases Risk of Incident HF, HFpEF

American College of Cardiology

Among a cohort of multiethnic participants without baseline cardiovascular disease, the presence of extracoronary calcification (ECC) at baseline was independently associated with an increased risk for heart failure (HF), especially HF with preserved ejection fraction (HFpEF).

article thumbnail

American College of Cardiology Sets Full Range of Education Sessions and Meetings ACC Scientific Session, ACC.24

DAIC

Cardiovascular Update for the Clinician: A Symposium by Valentin Fuster” will offer the latest advances in the treatment of cardiovascular disease and ways to integrate them into daily practice. 24 Education Sessions Symposiums at ACC The “Symposiums at ACC.24”

Education 105
article thumbnail

Abstract 4141446: Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors Promote Resiliency to High Pressure Stress in the Human Microvasculature

Circulation

Emerging evidence suggests that vascular stress from cardiovascular-related co-morbidities promotes microvascular dysfunction, a key component in the development of heart failure with preserved ejection fraction.

article thumbnail

Can heart failure phenotypes be predicted by cardiac remodelling peripartum or postpartum?

Frontiers in Cardiovascular Medicine

In the long term, a history of gestational hypertension and pre-eclampsia significantly increases the risk of future cardiovascular disease including chronic hypertension, coronary artery disease, heart failure and stroke.

article thumbnail

Hypertensive pregnancy disorder, an under‐recognized women specific risk factor for heart failure?

European Journal of Heart Failure

BMI, body mass index; CV, cardiovascular; CVD, cardiovascular disease; HELLP, haemolysis, elevated liver enzymes, low platelet count. Abstract During pregnancy, the maternal cardiovascular (CV) system undergoes major haemodynamic alterations ensuring adequate placental perfusion and a healthy pregnancy course.