Journal of the American Heart Association

JANUARY 19, 2024

BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome, leading to inflammation and cardiovascular diseases. mg/dL versus 97.9±37.6

Aortic valve 40

Aortic valve Cholesterol Aortic Stenosis 40

Physiologically Speaking

JANUARY 5, 2024

Exercise prevents and reverses cardiovascular disease, but whether high-intensity exercise training (HIIT) is safe and effective for adults after minimally invasive heart surgery is unknown. Exercise is a wonder drug for cardiovascular disease (CVD) prevention and reversal. Cardiac rehab works wonders.

Plaque 119

Plaque Physiology Exercise Cholesterol 119

DAIC

APRIL 7, 2024

It is well known that high levels of low-density lipoprotein (LDL) cholesterol, known as the “bad” cholesterol, heighten cardiovascular risk. A total of 154 patients (median age 62 years, 42% women) with high triglyceride levels and other risk factors for cardiovascular disease participated in the study at 24 sites in the U.S.

Cholesterol 116

Cholesterol Heart Attack Heart attacks Myocardial Infarction 116

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

There are numerous effective medications for modifying CAD but new pharmacologic therapies require increasingly large and expensive cardiovascular outcome trials to assess their potential impact on MACE and to obtain regulatory approval. For many disease areas, nearly a half of drugs are approved by the U.S.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Cardiometabolic Health Congress

AUGUST 23, 2024

Newly included risk factors— untreated vision loss and high LDL cholesterol —underscore the critical role of these elements in maintaining cognitive health. The Cholesterol Connection Cholesterol’s recognition as a risk factor for dementia marks a pivotal advancement in understanding, preventing, and delaying cognitive decline.

Dementia 52

Dementia Cholesterol Risk Factors CME 52

Frontiers in Cardiovascular Medicine

JULY 17, 2024

BackgroundSome clinical dyslipidemia cases do not respond to statins, known as statin-resistant familial hypercholesterolemia (SR-FH), in which patients are under a high cardiovascular risk despite statin therapy. Therefore, novel therapeutic alternatives are required.

Cholesterol 59

Cholesterol Cardiovascular Disease Heart Disease Circulation 59

Cardiometabolic Health Congress

JUNE 7, 2024

Ballantyne, MD , emphasized that while fellows may consider prevention “boring,” it is crucial for avoiding resource-intensive late-stage cardiovascular disease (CVD). He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

Dr. Paddy Barrett

NOVEMBER 8, 2024

Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication. Not zero risk.

Cholesterol 130

Cholesterol Plaque Heart Attack Heart attacks 130

The Beat Blog

SEPTEMBER 20, 2022

The overwhelming prevailing opinion among Cardiologists (including from our own Heartbeat Cardiology team w/hundreds of combined years of experience treating cardiovascular disease) is that people can benefit from adopting a Mediterranean diet, so let’s dive in and understand what that really means.

Diet 52

Diet Blood Pressure Cholesterol Cardiovascular Disease 52

Circulation

NOVEMBER 11, 2024

VA sites work with an AHA QI consultant to develop and deploy a local quality improvement plan to help overcome site specific barriers preventing Veterans from achieving optimal cholesterol levels. As this program is further implemented in our institution, we expect improvement in patient outcomes and prognosis.

Cardiovascular Disease 40

Cardiovascular Disease Diet Education Cholesterol 40

Circulation: Cardiovascular Quality & Outcomes

OCTOBER 20, 2023

Circulation: Cardiovascular Quality and Outcomes, Volume 16, Issue 11 , Page e009609, November 1, 2023. mg/dL,P=0.53), total cholesterol (191.2 mg/dL,P=0.53), total cholesterol (191.2 Further studies are needed to explore potential pathways between adverse cardiovascular disease outcomes and marijuana use.

Risk Factors 40

Risk Factors Cardiovascular Disease Cholesterol Biomarkers 40

Dr. Paddy Barrett

SEPTEMBER 12, 2023

An elevated Lp(a) is the most common genetic cholesterol disorder impacting 10-20% of the population. Everyone should have an Lp(a) blood test at least once, but this is an absolutely must-do test if you have an early family history of heart disease. Subscribe now 1 ODYSSEY Outcomes Committees and Investigators.

Cholesterol 52

Cholesterol Coronary Artery Disease Heart Disease Cardiovascular Disease 52

CardiacWire

JANUARY 21, 2024

The Takeaway Years of studies have shown that people with high Lp(a) have worse cardiovascular outcomes, and this new research adds solid particle-level evidence showing why this is the case, while further supporting the need for Lp(a)-lowering therapies.

Heart Disease 111

Heart Disease Research Cardiovascular Disease Outcomes 111

MIBHS

DECEMBER 29, 2023

Engaging in exercise can significantly contribute to maintaining a healthy heart and reducing the risk of cardiovascular diseases. Reducing Risk Factors Exercise helps manage and reduce risk factors associated with heart disease, such as high blood pressure, high cholesterol levels, obesity, and diabetes.

Exercise 52

Exercise Blood Pressure Risk Factors Cardiovascular Disease 52

Stroke Journal

FEBRUARY 1, 2024

Background:Adherence to the American Heart Association's Life’s Essential 8 (LE8) reduces the risk of cardiovascular disease. The independent variable or “exposure” was the LE8 score, which was based on data on blood pressure, blood glucose and cholesterol, body mass index, smoking, physical activity, sleep duration and diet.

Myocardial Infarction 40

Myocardial Infarction Blood Pressure Dementia Diet 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionAtherosclerosis, the occlusion of arteries due to the accumulation of fatty substances, cholesterol, calcium, and fibrin in the arterial walls, can result in reduced blood flow and a subsequent decrease in oxygen delivery to the organs supplied by the affected artery, including the brain.

Risk Factors 40

Risk Factors Cholesterol Cardiovascular Disease Stroke 40

Dr. Paddy Barrett

OCTOBER 31, 2023

If you separate those with a significantly elevated Lp(a) (>50mg/dl) and a normal Lp(a) by levels of healthy lifestyle, you see major differences in outcomes. Better lifestyle factors significantly reduced the risk of coronary artery disease, but even with an optimal lifestyle pattern, there was a small increase in risk 2.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Physiologically Speaking

JUNE 7, 2024

Lastly, insufficient sleep is also a massive health liability, leading to cardiovascular disease, diabetes, and cognitive decline. What’s the best way to spend our time when health is the outcome of interest? Barely 25% of adults meet the minimum 150 minutes of moderate to vigorous physical activity each week.

Exercise 52

Exercise Physiology Blood Pressure Outcomes 52

Physiologically Speaking

JULY 26, 2024

Dozens if not hundreds of (albeit observational) studies have linked a short sleep duration to a number of health conditions including type 2 diabetes and cardiovascular disease. A new study used wearable sleep data to show that several chronic diseases are associated with how we sleep.

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

Physiologically Speaking

JANUARY 26, 2024

However, there’s not great evidence that multivitamins benefit specific health outcomes. This hypothesis was studied in a randomized controlled trial known as the COcoa Supplement and Multivitamin Outcomes Study or COSMOS. Nutritional insurance? A health- and longevity-boosting powerhouse? Perhaps not.

Physiology 52

Physiology Diet Cardiovascular Disease BMI 52

DAIC

APRIL 24, 2024

The app also recorded other significant heart health risk factors, such as cholesterol, weight, and physical activity via integration with external sources including electronic medical records and fitness trackers. Change in blood pressure (BP), LDL cholesterol, and weight were evaluated from baseline to follow up.

Blood Pressure 116

Blood Pressure Cholesterol Technology Heart Attack 116

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

DAIC

FEBRUARY 1, 2024

The HEART Study is the world's first clinical trial investigating the use of genomic 'polygenic risk score (PRS) testing' to support the prevention of cardiovascular disease ( CVD ) in National Health Service (NHS) clinical practice. Prevention is at the heart of what we do as GPs and risk assessment underpins that.

Cardiovascular Disease 110

Cardiovascular Disease Risk Factors Best Practices Cholesterol 110

Cardiometabolic Health Congress

JANUARY 15, 2025

Atherosclerosisa key driver of cardiovascular disease (CVD)continues to be a significant global health issue. These cases are particularly challenging because traditional prevention strategies, which target known risks like high LDL cholesterol, hypertension, diabetes, and smoking, may not apply.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

DAIC

MARCH 13, 2024

Zerlasiran is a siRNA (short interfering RNA) designed to lower the body’s production of Lp(a), a key genetic risk factor for cardiovascular disease affecting up to 20% of the world’s population. Median percentage reduction in Lp(a) of 90% or greater were observed for both doses at week 36.

Cardiovascular Disease 98

Cardiovascular Disease Risk Factors Cholesterol Heart Attack 98

DAIC

MAY 21, 2024

A new peer-reviewed study published in the Journal of the American Heart Association , JAHA, found that Hello Heart’s digital heart health program was associated with reductions in blood pressure (BP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and weight. statins). .

Blood Pressure 52

Blood Pressure Cholesterol Risk Factors BMI 52

DAIC

MAY 29, 2024

More than 70% of patients with atherosclerotic cardiovascular disease (ASCVD) are still not achieving their LDL-C target, so there remains a vast unmet need among high-risk patients for more varied and effective treatment options. Raised cholesterol; [cited 2024 May 15. million deaths worldwide annually. 4 Pirillo A, et al.

Cholesterol 52

Cholesterol Cardiovascular Disease Atherosclerosis Myocardial Infarction 52

Journal of the American Heart Association

FEBRUARY 8, 2025

BackgroundObesity and hypercholesterolemia independently increase cardiovascular disease risk. ResultsIn people with obesity, bempedoic acid resulted in placebocorrected reductions in lowdensity lipoprotein cholesterol of 22.5% months in 6177 patients with baseline body mass index 30 kg/m2.ResultsIn and hsCRP of 23.2%

Obesity 40

Obesity Outcomes Cholesterol Myocardial Infarction 40

Circulation

NOVEMBER 28, 2023

BACKGROUND:Although low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non–high-density lipoprotein cholesterol (non–HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk.

Cholesterol 40

Cholesterol Blood Pressure Cardiovascular Disease Circulation 40

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. But they don’t guarantee the outcome.

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

DAIC

MAY 16, 2024

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Dr. Paddy Barrett

MAY 17, 2024

When stress is included in the risk factor profile for a future heart attack, it comes in third on the list after abnormal cholesterol and smoking 1. Regardless of what is driving the effect, it is clear that experiencing high levels of stress is associated with worse outcomes. The link is real. For both acute and chronic stress.

Heart Disease 104

Heart Disease Heart Attack Heart attacks Risk Factors 104

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. CLEAR trial had patients for both primary and secondary prevention of cardiovascular disease. Median follow up was for 40.6 There was 29.2 N Engl J Med.

Cholesterol 52

Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

Physiologically Speaking

DECEMBER 15, 2023

But resistance training hasn’t been the focus when it comes to improving cardiovascular health and preventing/reversing cardiovascular diseases (CVDs) — that honor goes to aerobic exercise training, for which the cardiovascular benefits are well-established and vast. The answer is yes.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

DECEMBER 15, 2023

But resistance training hasn’t been the focus when it comes to improving cardiovascular health and preventing/reversing cardiovascular diseases (CVDs) — that honor goes to aerobic exercise training, for which the cardiovascular benefits are well-established and vast. The answer is yes.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

The Beat Blog

MARCH 30, 2022

Cardiovascular diseases (CVD) affect nearly half of all American adults, and in addition to their impact on health outcomes, they have significant economic implications. are associated with these conditions, the largest across all disease categories. 17% of all annual healthcare costs in the U.S.

Blood Pressure 52

Blood Pressure Diabetes Risk Factors Hypertension 52

Hypertension Journal

OCTOBER 30, 2023

Background:Aortic stiffness, assessed as carotid-femoral pulse wave velocity, provides a measure of vascular age and risk for adverse cardiovascular disease outcomes, but it is difficult to measure. Hypertension, Ahead of Print. 1.82] per SD;P<0.0001). 1.82] per SD;P<0.0001).

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Heart Failure Blood Pressure 40