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This new insight into the flow of fats through the body points to new therapeutic targets for mitigating diseases like ASCVD, non-alcoholic fatty liver disease, obesity, diabetes, peripheral neuropathy, and neurodegeneration.
milla1cf Sun, 04/07/2024 - 18:09 April 7, 2024 — Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or “bad” cholesterol, levels by more than half on average, compared with a placebo.
Older general population-based studies found an inverse association between serum HDL-cholesterol and both cardiovasculardisease (CVD) events and mortality, but more recent data have suggested a U-shaped rela.
Background and objective This review compares non-laboratory-based and laboratory-based cardiovasculardisease (CVD) risk prediction equations in populations targeted for primary prevention. Laboratory predictors (eg, cholesterol and diabetes) had strong HRs, while body mass index in non-laboratory models showed limited effect.
BackgroundOne measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovasculardisease (CVD) risk. This association remained significant even after further adjustment for single measurements of NHHR.
Remnant cholesterol (remnant-C) contributes to atherosclerotic cardiovasculardisease (ASCVD), particularly in individuals with impaired glucose metabolism. Patients with impaired glu.
The 10 and 30year risks of total CVD, atherosclerotic CVD, coronary heart disease, stroke, and heart failure (HF) were estimated for patients without CVD history at each time point (n=1242910), using the social deprivation indexenhanced Predicting Risk of CardiovascularDisease EVENTs equations.
Background Cardiovasculardisease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. CTTC individual participant data and other meta-analyses informed statins’ effects on cardiovascular risks, incident diabetes, myopathy and rhabdomyolysis.
When it comes to a proper ‘explanation’ of cardiovasculardisease or a ‘plan’ to address it, you will have to learn or address a lot of this on your own. Some doctors are less interested in cardiovasculardisease; their particular interest may be in another area, e.g., migraines or gastrointestinal health.
It increases the likelihood of developing chronic conditions such as heart disease, diabetes, and high blood pressure. Food and Drug Administration (FDA) in 2021 as a once-weekly injection for chronic weight management in adults with obesity and at least one weight-related condition such as type 2 diabetes or hypertension.
Ballantyne, MD , emphasized that while fellows may consider prevention “boring,” it is crucial for avoiding resource-intensive late-stage cardiovasculardisease (CVD). He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia.
Newly included risk factors— untreated vision loss and high LDL cholesterol —underscore the critical role of these elements in maintaining cognitive health. The Cholesterol Connection Cholesterol’s recognition as a risk factor for dementia marks a pivotal advancement in understanding, preventing, and delaying cognitive decline.
The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. Each of these particles contains varying amounts of LDL cholesterol (CE) and triglycerides INSIDE the particle. CE = Cholesterol Ester. Share But what about LDL cholesterol? TG = Triglycerides.
Only when you have a clear idea of those three factors can you decide whether or not to take a medication to lower your LDL cholesterol. I use statins in the question posed above because that is what most people think and, in fact, what they will start with when looking to lower their LDL cholesterol with a medication. Not zero risk.
26th August 2022 And so, after a great deal of faffing about, my article on cardiovasculardisease ‘Assessing cardiovasculardisease: looking beyond cholesterol’ has been made free to view. Eric Westman is a staunch ally in the crusade to look at different causal models of cardiovasculardisease.
Background Implementation of the cardiovasculardisease (CVD) prevention guidelines in the UK has been repeatedly evaluated under the auspices of the British Cardiovascular Society in three Action on Secondary and Primary Prevention by Intervention to Reduce Events (ASPIRE) surveys in 1994–1995, 2008–2010 and 2017–2019.
(Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It Lipids in CardiovascularDisease Eduardo Z. HDL : The untold story ! Cardiovasc.
The overwhelming prevailing opinion among Cardiologists (including from our own Heartbeat Cardiology team w/hundreds of combined years of experience treating cardiovasculardisease) is that people can benefit from adopting a Mediterranean diet, so let’s dive in and understand what that really means.
This study sought to evaluate the prevalence of cardiovascular risk factors, overt cardiovasculardisease and cardiac imaging abnormalities using cardiac magnetic resonance (CMR), in participants with normal LVEF on completion of trastuzumab±anthracycline therapy at least 5 years previously. years (range 5.9–10.8
Most also had at least three of the following risk factors: elevated risk for or history of cardiovasculardisease, diabetes, low HDL (“good”) cholesterol and high body mass index. Patients’ average triglyceride level at baseline was about 900 mg/dL. Patients were randomly assigned to one of four groups.
Individuals with LVH were older, more likely to have hypertension, diabetes, known cardiovasculardisease (CVD) and elevated levels of cholesterol and creatinine. Results The age-standardised prevalence of LVH was 9% (n=875) according to any of the three ECG criteria. to 1.83)), low educational level (1.49 (1.28
BackgroundAsian people in the United States have different sociodemographic and health‐related characteristics that might affect cardiovasculardisease (CVD) risk by ethnicity and birthplace. Journal of the American Heart Association, Ahead of Print. However, they are often studied as a monolithic group in health care research.
BACKGROUND:The relationship between marijuana use and cardiovascular health remains uncertain, with several observational studies suggesting a potential association with increased adverse atherosclerotic cardiovasculardisease (ASCVD) outcomes. P=0.13; 82% versus 75%,P=0.95), diabetes (4.8% versus 18.8%,P=0.76;
Engaging in exercise can significantly contribute to maintaining a healthy heart and reducing the risk of cardiovasculardiseases. Reducing Risk Factors Exercise helps manage and reduce risk factors associated with heart disease, such as high blood pressure, high cholesterol levels, obesity, and diabetes.
So, let’s unwind how the innovations in cath lab software are reshaping the method of cardiovascular care post-Covid-19. SOURCE Impact of COVID-19 in digital cardiac health care COVID-19 complications are more acute in patients with cardiovasculardiseases.
A healthy lifestyle, in this instance, is defined by a combination of: BMI Nutrition Smoking Status Activity Levels Blood Pressure Diabetes Status Cholesterol Levels All of which are highly modifiable. An elevated Lp(a) does increase the risk of early cardiovasculardisease, but that risk is not set in stone.
We talk about the ketogenic diet as a metabolic therapy for type 1 diabetes. Dozens if not hundreds of (albeit observational) studies have linked a short sleep duration to a number of health conditions including type 2 diabetes and cardiovasculardisease. Welcome to the Physiology Friday newsletter.
Lastly, insufficient sleep is also a massive health liability, leading to cardiovasculardisease, diabetes, and cognitive decline. Barely 25% of adults meet the minimum 150 minutes of moderate to vigorous physical activity each week. We’re living through an epidemic of inactivity.
The 2023 Almanac results derived from the Global Burden of Disease (GBD) and spanning 1990 to 2022, were recently published in the Journal of American College of Cardiology. The post Global Trends in CardiovascularDiseases: Insights from the 2023 Almanac appeared first on Cardiology Update. Original article: Mensah GA et al.
Atherosclerotic cardiovasculardisease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3
Atherosclerosisa key driver of cardiovasculardisease (CVD)continues to be a significant global health issue. The Global Burden of Disease data (2023) highlights a grim reality: while high-income countries have seen some success in managing CVD, LMICs now account for most CVD-related deaths.
The HEART Study is the world's first clinical trial investigating the use of genomic 'polygenic risk score (PRS) testing' to support the prevention of cardiovasculardisease ( CVD ) in National Health Service (NHS) clinical practice. Prevention is at the heart of what we do as GPs and risk assessment underpins that.
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovasculardisease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4
Clinicians currently use two separate risk models to assess patients’ chances of having heart attacks , strokes , and other major cardiovascular events. Clinicians currently use two separate risk models to assess patients’ chances of having heart attacks , strokes , and other major cardiovascular events.
If you start in your 20s and 30s and get the following fundamentals right, you are well on course to massively reducing your risk of heart disease and also living longer. No diabetes or Pre-Diabetes. Normal Cholesterol Levels. Here are your targets. Being physically active. Normal Blood Pressure. Good Nutrition.
It all comes down to: What your priorities are What your objectives are Your risk tolerance Your ability to update that risk model Where you draw the line of ‘risk’ equating to ‘causation’ The same is true when it comes to the question of statins ‘causing’ diabetes. What to do? Let’s dive in.
Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. On the far end of that line is type two diabetes. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants.
Background:Inflammation and cholesterol jointly contribute to cardiovasculardisease and mortality. The relative contributions of inflammation and cholesterol to the risk of future cardiovascular events might shift according to pre-existing traits of each individual. female, mean age 46.8 ± 19.7
Introduction:Historically, Middle-Eastern (ME) immigrants have been aggregated with Non-Hispanic White (NHW) individuals, masking disparities in cardiovasculardiseases (CVD). Circulation, Volume 150, Issue Suppl_1 , Page A4139303-A4139303, November 12, 2024. NHW&6.8% years, [SD=18.9]) with 51% being female. NHW&6.8%
BackgroundHigher cholesterol absorption has been reported to be related to a higher incidence of cardiovascular events (CVEs). Baseline and 24‐week follow‐up blood samples were analyzed for cholesterol absorption (eg, campesterol) and synthesis markers (eg, lathosterol). Journal of the American Heart Association, Ahead of Print.
BACKGROUND:Lp(a; Lipoprotein[a]) is a predictor of atherosclerotic cardiovasculardisease (ASCVD); however, there are few algorithms incorporating Lp(a), especially from real-world settings. Circulation: Genomic and Precision Medicine, Ahead of Print. women, and 7.7% Over a mean follow-up of 6.8 across Lp(a) groups.
Insulin resistance is a major risk factor for the leading causes of death, the leading one being cardiovasculardisease. Everyone sits somewhere on the scale of insulin sensitivity from very insulin sensitive to very insulin resistant at the point of type 2 diabetes. Low HDL Cholesterol. Measuring Insulin Resistance.
“We are witnessing a paradigm shift in how valvular heart diseases are diagnosed and treated,” said Partho Sengupta , Henry Rutgers Professor of Cardiology and chief of the Division of CardiovascularDisease and Hypertension at Rutgers Robert Wood Johnson Medical School.
Introduction One of the biggest causes of death worldwide continues to be cardiovasculardisease. In this blog, we will unravel some of the most common myths about cardiac health and heart diseases while providing accurate and evidence-based information to promote a healthy lifestyle. Myth #3: Heart diseases only affect men.
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