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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

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Association of Lp(a) With Stroke and Cerebral Injury on MRI: Insights From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) and Investigation of Neurocognitive Aging MRI (SOL-INCA MRI)

Stroke Journal

Stroke, Ahead of Print. Linear and multivariate logistic regression assessed the association of Lp(a) with (1) self-reported stroke or TIA, (2) cerebral injury defined as self-reported stroke or TIA or evidence of a stroke on brain magnetic resonance imaging, (3) white matter hyperintensity volume, and (4) silent brain infarcts.

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Intermediate and long-term residual cardiovascular risk in patients with established cardiovascular disease treated with statins

Frontiers in Cardiovascular Medicine

Results CV event rates among patients treated with statins who have established CV disease, including coronary artery disease, cerebrovascular disease, or peripheral arterial disease, accumulate over time, with a cumulative incidence of CV events reaching up to approximately 40% over 10 years.

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Epidemiology of atherosclerotic cardiovascular disease in polygenic hypercholesterolemia with or without high lipoprotein(a) levels

Frontiers in Cardiovascular Medicine

Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). 3.17, P  = 0.006). Occurrence of acute CAD was higher in H-Lpa men (HR 3.1,

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Abstract DP15: Increased Severity of Blood-Brain Barrier Disruption is Associated with Greater Burden of Cerebrovascular Disease in Asymptomatic Patients

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ADP15-ADP15, February 1, 2025. Background:White matter hyperintensities (WMH) of presumed vascular origin can be associated with vascular cognitive impairment and dementia. However, WMH are also seen in asymptomatic subjects. FLAIR/T1 images were segmented to create WMH masks.

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Abstract TMP102: Association of Lipoprotein(a) With Stroke and Cerebral Injury: Insights From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and Investigation of Neurocognitive Aging-MRI (SOL-INCA MRI)

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP102-ATMP102, February 1, 2024. Introduction:Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease; however, its association with cerebrovascular disease is not as well established.Methods:Data from HCHS/SOL, a population-based cohort of Hispanics/Latinos, was utilized.

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Abstract TP271: A Retrospective Analysis of Demographic and Clinical Variables Within a Single Center Young Stroke Cohort

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATP271-ATP271, February 1, 2024. Introduction:Despite significant efforts to increase public awareness of cerebrovascular disease, the incidence of stroke and transient ischemic attack (TIA) in young adults has remained elevated, representing a major public health concern.

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