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Lipid metabolism-associated metabolites on cardiovascular diseases: a two-sample Mendelian randomized study

Frontiers in Cardiovascular Medicine

BackgroundThere is a growing body of evidence indicating that metabolites are associated with an increased risk of cardiovascular diseases (CVDs), the underlying causality of these associations remains largely unchallenged. After Bonferroni correction, causal associations were found to be significant with p-values less than 0.05.

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Pregnancy complications linked to cardiovascular disease in the family

Science Daily - Heart Disease

Women who have experienced pregnancy complications have an increased risk of cardiovascular disease. The findings suggest that genes and shared environmental factors may influence the association between pregnancy complications and cardiovascular disease risk.

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Cholesterol may not be the only lipid involved in trans fat-driven cardiovascular disease

Medical Xpress - Cardiology

Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns.

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P-selectin glycoprotein ligand-1 and cardiovascular diseases: from a general perspective to an HIV infection context

Frontiers in Cardiovascular Medicine

Globally, cardiovascular diseases (CVDs) are a leading cause of death as they are responsible for the loss of at least 17 million lives annually. It has been established that the pathogenesis of CVDs is strongly associated both with inflammation as well as with inflammatory markers (proteins, cytokines, amongst others).

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Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study

Heart BMJ

Background Menopause is a timely opportunity to screen for cardiovascular disease (CVD) and intervene with healthier lifestyles. We investigated the association between premature/early menopause and the likelihood of CVD and whether a healthy lifestyle is associated with a lower likelihood of CVD in menopausal woman.

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The roles of neutrophils in cardiovascular diseases

Frontiers in Cardiovascular Medicine

The immune response plays a vital role in the development of cardiovascular diseases (CVDs). As a crucial component of the innate immune system, neutrophils are involved in the initial inflammatory response following cardiovascular injury, thereby inducing subsequent damage and promoting recovery.

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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Frontiers in Cardiovascular Medicine

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Consequently, there has been a notable increase in interest towards drug targets targeting lactylation in immune cells, prompting further exploration.