HeartRhythm

APRIL 1, 2025

Identifying children with hypertrophic cardiomyopathy (HCM) at high risk for sudden cardiac death (SCD) is an important part of clinical care.1,2

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Frontiers in Cardiovascular Medicine

JULY 11, 2024

BackgroundDilated cardiomyopathy (DCM) is a heterogeneous myocardial disorder with diverse genetic or acquired origins. Notable advances have been achieved in discovering and understanding the genetics of DCM.

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Frontiers in Cardiovascular Medicine

MARCH 13, 2024

Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late during pregnancy or early after delivery. The issue is relevant since some arrhythmias are associated to sudden cardiac death occurring in young patients, and the overall risk does not cease during the early postpartum period.

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HeartRhythm

APRIL 30, 2024

Sudden cardiac death represents a significant mortality factor in hypertrophic cardiomyopathy (HCM). Nevertheless, the validation of the existing risk prediction model in the pediatric population remains insufficiently explored.

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Nature Reviews - Cardiology

JANUARY 22, 2024

Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00989-0 A molecular autopsy is undertaken in cases of sudden cardiac death with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death.

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Open Heart

APRIL 20, 2022

Objectives To describe a cohort of patients with arrhythmogenic left ventricular cardiomyopathy (ALVC), focusing on the spectrum of the clinical presentations. Twenty-one (41%) had normal echocardiogram, 13 (25%) a hypokinetic non-dilated cardiomyopathy (HNDC) and 17 (33%) a dilated cardiomyopathy (DCM).

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Cardiomyopathy Chest Pain Sudden Cardiac Death Heart Failure 52

Heart BMJ

JUNE 25, 2024

Hypertrophic cardiomyopathy (HCM) stands as one of the most common inheritable myocardial disease and is often marked by its association with sudden cardiac death (SCD) in the young. 1 2 Traditionally, risk assessment in HCM has focused mainly on estimating the likelihood of SCD.

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BoardVitals - Cardiovascular

MAY 1, 2017

Whether you’re gearing up for your Family Medicine or Cardiology Board Exam, you’ll need to master the topic of Hypertrophic Cardiomyopathy (HCM). It is crucial for every medical physician to recognize patients who are at risk of sudden cardiac death due to their underlying medical condition.

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Cardiomyopathy Sudden Cardiac Death Bicuspid/Mitral Electrocardiogram 52

DAIC

APRIL 9, 2024

Maron, MD , a cardiologist and director of the Hypertrophic Cardiomyopathy Center at Lahey Hospital and Medical Center in Burlington, Massachusetts, and the study’s lead author. It causes the heart muscle to become stiff and thick, making it harder for the heart to pump blood properly and increasing the risk of sudden cardiac death.

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American College of Cardiology

MARCH 12, 2025

Although the 2024 ACC/American Heart Association (AHA) and 2023 European Society of Cardiology (ESC) guidelines stratify well overall the risk of sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM).

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HeartRhythm

MAY 7, 2024

Implantable cardioverter defibrillator (ICD) prevents sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM). Catheter ablation has been shown to effectively reduce ventricular tachycardia (VT) recurrence, yet its efficacy in patients without an ICD implantation remains uncertain.

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HeartRhythm

OCTOBER 27, 2024

Sudden cardiac death (SCD) remains a major health problem in all continents. It usually affects older patients suffering from coronary artery disease and cardiomyopathies. This group of patients defines the sudden arrhythmic death syndrome (SADS) where the cause of death is unknown.

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Sudden Cardiac Death Coronary Artery Disease Cardiac Arrest Cardiomyopathy 73

HeartRhythm

APRIL 1, 2025

A common characteristic of almost all inherited cardiac disorders is the inherent risk of sudden cardiac death. Hypertrophic cardiomyopathy (HCM) is one of these conditions and, indeed, risk stratification attempts have been numerous.

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Cardiomyopathy Sudden Cardiac Death 40

DAIC

FEBRUARY 16, 2024

The study, titled " Targeted Therapy with Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy " (TaRGET), will be led by the research team at PHRI and will involve collaboration with multiple organizations in addition to AMO Pharma including the Hearts in Rhythm Organization (HiRO).

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American College of Cardiology

MAY 2, 2024

What is the prognostic value of extent of late gadolinium enhancement (LGE) in predicting sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM)?

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HeartRhythm

APRIL 30, 2024

Sudden cardiac death (SCD) risk stratification is based on clinically recognized risk factors (RF), such as reduced left ventricular (LV) ejection fraction (EF), heart failure (HF), prior myocardial infarction (MI), and syncope. These RFs fail to capture the majority of SCDs.

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Circulation: Genomic and Precision Medicine

DECEMBER 7, 2023

BACKGROUND:Few clinical data are available onNEXNmutation carriers, and the gene’s involvement in cardiomyopathies or sudden death has not been fully established. years), 21 presented with dilated cardiomyopathy (prevalence, 0.33%), and 3 presented with hypertrophic cardiomyopathy (prevalence, 0.14%).

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DAIC

MAY 9, 2024

The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). Ommen, MD, FACC , medical director of the Mayo Hypertrophic Cardiomyopathy Clinic and chair of the guideline writing committee.

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Cardiomyopathy Pediatrics Quality of Life Sudden Cardiac Death 52

Journal of Cardiovascular Electrophysiology

DECEMBER 2, 2024

To improve arrhythmogenic cardiomyopathy (ACM) patient care four pillars of ACM research are necessary. The first pillar to improve ACM is cohort studies in which the genotype-specific natural history of disease is described, and subsequently genotype-specific risk calculators can be developed, such as the DSP and PLN risk calculators.

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HeartRhythm

NOVEMBER 27, 2023

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by replacement of ventricular myocardial by fibrofatty scar tissue which underlies morpho-functional ventricular abnormalities and life-threatening ventricular arrhythmias potentially responsible of sudden cardiac death (SCD), mostly in young people and athletes 1,2.

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HeartRhythm

DECEMBER 31, 2023

There has been a recent surge of interest in efforts to refine the risk stratification for sudden cardiac death (SCD) in children and adolescents with hypertrophic cardiomyopathy (HCM).

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HeartRhythm

APRIL 30, 2024

Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD). Since approval in late 2012, the subcutaneous implantable cardioverter-defibrillator (SICD) has been used as an alternative to the traditional transvenous ICD (TV-ICD) for SCD prevention in HCM.

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HeartRhythm

APRIL 30, 2024

Predictive factors of benefit from implantation of an implantable cardioverter-defibrillator (ICD) for primary prophylaxis of sudden cardiac death in patients with nonischemic cardiomyopathy (NICM) have not been clarified.

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HeartRhythm

SEPTEMBER 14, 2023

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiomyopathy resulting from disordered function of the intercalated discs with mainly arrhythmic manifestation, which can be difficult to diagnose because of its variable presentation. The incidence of ARVC is reported to be 1:2000 to 1:5000.

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European Journal of Heart Failure

SEPTEMBER 24, 2023

Abstract Cardiomyopathies represent significant contributors to cardiovascular morbidity and mortality. Furthermore, medications targeting core disease processes and/or their downstream adverse effects have been introduced for several cardiomyopathies.

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Circulation: Arrhythmia and Electrophysiology

FEBRUARY 3, 2025

BACKGROUND:Over the past decades, hypertrophic cardiomyopathy has become a contemporary treatable disease. Secondary outcomes included trends of sudden cardiac death, appropriate/inappropriate shocks, and ICD-related complications.RESULTS:In total, 234 studies (N=92 500, 514 748 patient-years) met inclusion criteria.

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HeartRhythm

APRIL 30, 2024

Frequent premature ventricular contractions (PVCs) are linked to development of cardiomyopathy (CM) characterized by reduced LV ejection fraction and increased risk of sudden cardiac death. PVC-CM is thought to be triggered by elevated mechanical myocardial strain due to dyssynchronous contraction during PVCs.

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HeartRhythm

APRIL 30, 2024

Hypertrophic cardiomyopathy (HCM) is associated with risk of sudden cardiac death (SCD). Since approval in late 2012, the subcutaneous implantable cardioverter-defibrillator (SICD) has been used as an alternative to the traditional transvenous ICD (TV-ICD) for SCD prevention in HCM.

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Defibrillator Sudden Cardiac Death Cardiomyopathy 40

HeartRhythm

APRIL 30, 2024

Hypertrophic cardiomyopathy (HCM) has a prevalence of 1 in 500 people and highly increases the risk of sudden cardiac death (SCD). Diagnosis is typically based on the Echocardiogram, while cardiac MRI is used for detection of myocardial scarring through Late Gadolinium Enhancement (LGE), an important risk marker for SCD.

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Circulation: Genomic and Precision Medicine

NOVEMBER 29, 2024

BACKGROUND:No disease-specific therapy currently exists for arrhythmogenic right ventricular cardiomyopathy (ARVC), a progressive cardiogenetic condition conferring elevated risk for ventricular arrhythmias, heart failure, and sudden cardiac death. Emerging gene therapies have the potential to fill this gap.

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Cardiomyopathy Sudden Cardiac Death Arrhythmia Heart Failure 40

DAIC

FEBRUARY 22, 2024

Researchers Elizabeth Jordan and Ray Hershberger, MD discuss the results of genetic tests that indicate a risk for dilated cardiomyopathy. Dilated cardiomyopathy can be a silent killer DCM is a condition in which the heart muscle weakens and the left ventricle enlarges. The Dilated Cardiomyopathy Consortium was funded by a $12.4

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HeartRhythm

OCTOBER 19, 2023

Hypertrophic cardiomyopathy (HCM)-related sudden cardiac death (SCD) rates with contemporary management are low; however, high-intensity exercise can induce fatal arrhythmias in HCM patients. Thus, current guidelines recommend avoiding high-intensity exercise in HCM patients at high risk for SCD1,2.

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Journal of the American Heart Association

MARCH 3, 2025

BackgroundArrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and sudden cardiac death, along with progressive cardiac remodeling and myocardial inflammation. Journal of the American Heart Association, Ahead of Print.

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European Journal of Heart Failure

FEBRUARY 26, 2024

Dilated cardiomyopathy with arrhythmic phenotype. Abstract Aims Dilated cardiomyopathy (DCM) with arrhythmic phenotype combines phenotypical aspects of DCM and predisposition to ventricular arrhythmias, typical of arrhythmogenic cardiomyopathy.

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Cardiomyopathy Sudden Cardiac Death Arrhythmia Tachycardia 40

HeartRhythm

FEBRUARY 13, 2024

Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death (SCD) in youth. Cardiac; magnetic resonance imaging (CMR) has been invaluable in improving the risk stratification of these patients for SCD1.

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Medical Xpress - Cardiology

APRIL 8, 2025

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed an innovative gene-therapy strategy that could transform the treatment of arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and highly penetrant inherited cardiac disorder with an elevated risk of sudden cardiac death.

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Circulation: Genomic and Precision Medicine

NOVEMBER 28, 2023

BACKGROUND:Hypertrophic cardiomyopathy (HCM) is an important cause of sudden cardiac death associated with heterogeneous phenotypes, but there is no systematic framework for classifying morphology or assessing associated risks. Circulation: Genomic and Precision Medicine, Ahead of Print.

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