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Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up

Frontiers in Cardiovascular Medicine

BackgroundPediatric cardiomyopathies are rare but life-threatening conditions with high mortality. ConclusionsThis study underscores the importance of early diagnosis, genetic testing, and integrated management in pediatric cardiomyopathies.

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Exercise, new drug class recommended for management of hypertrophic cardiomyopathy

Science Daily - Heart Disease

Experts released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The guideline reiterates the importance of collaborative decision-making with patients who have HCM and provides updated recommendations for the most effective treatment pathways for adult and pediatric patients.

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Contemporary review on pediatric hypertrophic cardiomyopathy: insights into detection and management

Frontiers in Cardiovascular Medicine

Hypertrophic cardiomyopathy is the most common genetic cardiac disorder and is defined by the presence of left ventricular (LV) hypertrophy in the absence of a condition capable of producing such a magnitude of hypertrophy. Over the past decade, guidelines on the screening, diagnostic, and management protocols of pediatric primary (i.e.,

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Jeffrey A. Towbin, MD, FACC, Receives ACC Lifetime Achievement Award

American College of Cardiology

Towbin, MD, FACC, has evolved to be a renowned leader, researcher and clinician in pediatric cardiology. 25 on Saturday during the Opening Showcase Session.

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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice

Circulation: Heart Failure

Recent evidence suggests that loss of PRDM16 expression is associated with cardiomyopathy development in mice, although its role in human cardiomyopathy development is unclear. BACKGROUND:PRDM16 plays a role in myocardial development through TGF-β (transforming growth factor-beta) signaling.

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VENTRICULAR ARRHYTHMIAS DURING EXERCISE TESTING IN PEDIATRIC PATIENTS WITH ARRHYTHMOGENIC CARDIOMYOPATHY AT FIRST PRESENTATION AND WITH DIFFERENT VENTRICULAR INVOLVEMENT Correlation between arrhythmic expression and phenotype: is really possible?

HeartRhythm

Ventricular arrhythmias (VAs) may be the first clinical manifestation in pediatric patients with arrhythmogenic cardiomyopathy (ACM). The arrhythmogenicity of exercise testing (ET) remains unclear.

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Abstract 4134590: Procedural Related Major Adverse Events of Cardiac Catheterization in Pediatric Patients with Cardiomyopathy: Insights from IMPACT Registry

Circulation

Background:Despite the role of cardiac catheterization for hemodynamic assessment and endomyocardial biopsy (EMB) in children with cardiomyopathy, data on procedure-related major adverse events (MAE) in this population is lacking. We aim to describe the rate of MAE in children with cardiomyopathy undergoing cardiac catheterization.