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BackgroundPediatric cardiomyopathies are rare but life-threatening conditions with high mortality. ConclusionsThis study underscores the importance of early diagnosis, genetic testing, and integrated management in pediatriccardiomyopathies.
Experts released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The guideline reiterates the importance of collaborative decision-making with patients who have HCM and provides updated recommendations for the most effective treatment pathways for adult and pediatric patients.
Hypertrophic cardiomyopathy is the most common genetic cardiac disorder and is defined by the presence of left ventricular (LV) hypertrophy in the absence of a condition capable of producing such a magnitude of hypertrophy. Over the past decade, guidelines on the screening, diagnostic, and management protocols of pediatric primary (i.e.,
Towbin, MD, FACC, has evolved to be a renowned leader, researcher and clinician in pediatric cardiology. 25 on Saturday during the Opening Showcase Session.
Recent evidence suggests that loss of PRDM16 expression is associated with cardiomyopathy development in mice, although its role in human cardiomyopathy development is unclear. BACKGROUND:PRDM16 plays a role in myocardial development through TGF-β (transforming growth factor-beta) signaling.
Ventricular arrhythmias (VAs) may be the first clinical manifestation in pediatric patients with arrhythmogenic cardiomyopathy (ACM). The arrhythmogenicity of exercise testing (ET) remains unclear.
Background:Despite the role of cardiac catheterization for hemodynamic assessment and endomyocardial biopsy (EMB) in children with cardiomyopathy, data on procedure-related major adverse events (MAE) in this population is lacking. We aim to describe the rate of MAE in children with cardiomyopathy undergoing cardiac catheterization.
Introduction:Dilated cardiomyopathy (DCM) is a common cardiomyopathy characterized by ventricular dilatation and systolic dysfunction. Circulation, Volume 150, Issue Suppl_1 , Page A4144727-A4144727, November 12, 2024.
Cardiac manifestations of laminopathies include atrial and ventricular arrhythmias, atrioventricular (AV) conduction disorders, and cardiomyopathy, with or without skeletal muscle involvement. Due to its rarity and previous cardiac characterization as adult-onset, pediatric data is limited.
When treatable causes are excluded, studies to define causes are often abandoned, resulting in a diagnosis of end-stage idiopathic cardiomyopathy. The frequency of pathogenic variants was similar in pediatric (42.9%) and adult (43.6%) samples, but the distribution of mutated genes differed (P=8.30×10-4).
Objective To report the number of thromboembolic complications in a cohort of pediatric and young adult patients presenting with atrial fibrillation (AFib) or atrial flutter (AFl) while also assessing anticoagulation practice in a multicenter cohort of young patients with these arrhythmias.
The post EM Quick Hits 35 – 10 Best Papers of 2021, Peripartum Cardiomyopathy, Crashing Asthmatic, Febrile Neutropenia, Anaphylaxis update appeared first on Emergency Medicine Cases.
Introduction Heart transplantation (HT) is the only treatment option in children with heart failure secondary to cardiomyopathies and non-reparable congenital heart diseases. 24 patients (88.8%) were diagnosed with dilated cardiomyopathy, 2 (7.4%) with restrictive cardiomyopathy, and 1 (3.7%) with hypertrophic cardiomyopathy.
Left Bundle Branch Area Pacing (LBBAP) has emerged as an alternate pacing strategy to reduce the risk of pacing-induced cardiomyopathy (PICM) and improve cardiac synchronization. Data on LBBAP feasibility and outcomes in the pediatric population are limited to mixed cohorts that include adults with congenital heart disease (CHD).
CHD was the pre-PHT diagnosis in 21(62%) of stroke Pts, cardiomyopathy in 12(35%) and acquired heart disease in 1(3%). Data are presented as frequency (%) or median (Inter Quartile Range-IQR).Results:Of Median age of HT in these Pts was 6 yrs(1,13) (Table 1), 21(62%) were male.
Methods We performed a retrospective analysis to examine the clinical manifestations, genetic traits, and the relationship between PD and mitochondrial function in a pediatric patient. Laboratory tests and echocardiography confirmed heart failure and hypertrophic cardiomyopathy.
IntroductionFocal atrial tachycardia (FAT) is predominant in the pediatric population. A 12-lead electrocardiogram revealed a narrow QRS complex tachycardia with a rate of 157 beats per minute and a prolonged RP relationship.
Cardiomyopathy Finally most importantly prosthetic heart valves & other Intra cardiac devices. Turk J Pediatr. (Most IVF pregnancies seem to need it for some unknown reason) Risk of VTE Recurrent pregnancy loss(Placental micro-circulation clogging) SLE/APLA syndrome /Scleroderma VTE related PAH Mitral valve disease with AF.
While two-thirds of patients in the pediatric US experience demonstrate a persistent scar on cardiac MRI at 6 month follow-up, a repeat MRI in this case was normal with complete resolution of previously seen abnormalities.
Childhood-onset cardiomyopathies represent a rare and poorly understood subset of cardiac disorders. In a recent study published in the European Heart Journal, investigators delved into the demographics and prognosis of pediatriccardiomyopathy patients within the inaugural European Cardiomyopathy Registry. Eur Heart J.
BACKGROUND:The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation (HT) in 2016 for pediatric patients and 2018 for adult patients. Children with cardiomyopathy and adults with CHD did not experience the mortality benefits experienced by adults with cardiomyopathy and children with CHD.
In this pediatric study, it was 71% successful and better than amiodarone. Procainamide is another reasonable solution to the problem. It does not block the AV node but does slow phase 0 of depolarization, which will also frequently break the re-entrant cycle.
The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). Ommen, MD, FACC , medical director of the Mayo Hypertrophic Cardiomyopathy Clinic and chair of the guideline writing committee.
There has been a recent surge of interest in efforts to refine the risk stratification for sudden cardiac death (SCD) in children and adolescents with hypertrophic cardiomyopathy (HCM).
Sudden cardiac death represents a significant mortality factor in hypertrophic cardiomyopathy (HCM). Nevertheless, the validation of the existing risk prediction model in the pediatric population remains insufficiently explored.
BackgroundPediatric dilated cardiomyopathy often leads to death or cardiac transplantation. ConclusionsProgressive deterioration in LV contractile function and increasing LV dilation are associated with both early and continuing mortality in children with dilated cardiomyopathy. P<0.001).ConclusionsProgressive
What is the association between late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (cMRI) and sudden cardiac death (SCD) in pediatric patients with hypertrophic cardiomyopathy (HCM), and does it add to pediatric SCD risk models?
Identifying children with hypertrophic cardiomyopathy (HCM) at high risk for sudden cardiac death (SCD) is an important part of clinical care.1,2 1,2 International guidelines recommend using pediatric-specific SCD risk prediction calculators that use baseline clinical parameters to provide individualized estimates of 5-year risk.13
Biallelic lossoffunction mutations in ALPK3 lead to pediatriccardiomyopathy. Loss of ALPK3 at germline and adult stages leads to dilated cardiomyopathy. Journal of the American Heart Association, Ahead of Print. BackgroundALPK3 ( protein kinase 3) is an atypical kinase highly expressed in human and murine hearts.
The granulomatous inflammation affects the heart, causing an infiltrative cardiomyopathy The most common manifestations of cardiac sarcoidosis are atrioventricular (AV) block and ventricular tachyarrhythmias (VT). Lung involvement is the typical presentation. Cardiac sarcoidosis (CS) is seen in ~10% of patients with sarcoidosis.
However, women remain concentrated in certain specialties (pediatrics and women’s specialties) and are less likely to be promoted to healthcare leadership roles. Since 2019, women have accounted for (50.5%) of most US medical students.
Institutional Coronary Artery Bypass Case Volumes and Outcomes European Journal of Heart Failure October 2023 Makoto Mori Robotic Mitral Valve Repair for Degenerative Mitral Regurgitation The Annals of Thoracic Surgery August 2023 Carlos Diaz-Castrillion Volume-Failure to Rescue Relationship in Acute Type A Aortic Dissections: An Analysis of The Society (..)
Institutional Coronary Artery Bypass Case Volumes and Outcomes European Journal of Heart Failure October 2023 Makoto Mori 1 Robotic Mitral Valve Repair for Degenerative Mitral Regurgitation The Annals of Thoracic Surgery August 2023 Carlos Diaz-Castrillion 2 Volume-Failure to Rescue Relationship in Acute Type A Aortic Dissections: An Analysis of The (..)
BACKGROUND:Sudden cardiac death is the most common cause of death in childhood hypertrophic cardiomyopathy (HCM). Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Recently, 2 risk scores have been developed to estimate the 5-year risk of sudden cardiac death.
It is often drug-resistant and likely to occur concomitantly with tachycardia-induced cardiomyopathy, making radiofrequency catheter ablation the preferred treatment. The success rate of ablation for atrial flutter was 100%, except in one child with underlying cardiomyopathy who experienced recurrence.
New science presented at AHA 2024 and simultaneously published in JACC: Advances provide insights on emerging topics such as the use of artificial intelligence (AI)-enabled left atrial (LA) volumetry in coronary artery calcium (CAC) scans to predict atrial fibrillation (AFib); the role of treating hospitals in facilitating cardiac rehabilitation (CR); (..)
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