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BackgroundClinical and geneticpredispositions are significant in predicting atrial fibrillation (AF); however, their role in patients with hypertrophic cardiomyopathy (HCM) remains unclear. Journal of the American Heart Association, Ahead of Print.
Geneticpredisposition to ventricular scarring is associated with heart failure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.
Geneticpredisposition to long QT syndrome was explored using rare variant analysis.ResultsSeventyfour independent loci were obtained with genomewide significance across the 6 traits (P<5108). Middle Eastern PRSs were developed using clumping and thresholding, and their performance was compared with 26 published PRSs.
Heart disease remains one of the leading causes of death worldwide, often attributed to a mix of lifestyle choices, environmental factors, and geneticpredispositions. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.
Heavy and repeated binge drinking can lead to alcoholic cardiomyopathy, a condition in which the heart muscle weakens and struggles to pump blood efficiently. The Role of Genetics and Individual Risk Factors Individual risk factors play a crucial role in how alcohol affects the heart.
Background:Clinical and geneticpredispositions are significant in predicting atrial fibrillation (AF); however, their role in patients with hypertrophic cardiomyopathy (HCM) remains unclear. Stroke, Volume 56, Issue Suppl_1 , Page ATMP101-ATMP101, February 1, 2025.
BACKGROUND:Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear.
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