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Understanding Childhood Cardiomyopathies: Insights from the First European Registry

Cardiology Update

Childhood-onset cardiomyopathies represent a rare and poorly understood subset of cardiac disorders. In a recent study published in the European Heart Journal, investigators delved into the demographics and prognosis of pediatric cardiomyopathy patients within the inaugural European Cardiomyopathy Registry. months (IQR: 11.3–15.3),

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Idiopathic dilated cardiomyopathy

All About Cardiovascular System and Disorders

Idiopathic dilated cardiomyopathy Idiopathic dilated cardiomyopathy is a form of dilated cardiomyopathy with unknown etiology characterised by progressive left ventricular dilatation and systolic dysfunction. The incidence of idiopathic dilated cardiomyopathy varies from 3-10 cases per 100,000 population.

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Hypertrophic Cardiomyopathy

All About Cardiovascular System and Disorders

Hypertrophic cardiomyopathy is a genetic disorder with a guarded prognosis which occurs in about 1:500 individuals. The most common symptom of hypertrophic cardiomyopathy is dyspnoea which occurs in 90% of cases and is due to elevated left ventricular diastolic pressures as a consequence of the diastolic dysfunction.

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2024 ACC/AHA/Multisociety Guidelines for Management of Hypertrophic Cardiomyopathy Released

All About Cardiovascular System and Disorders

2024 ACC/AHA/Multisociety Guidelines for Management of Hypertrophic Cardiomyopathy is now available online with free access at JACC website. Those who are in a hurry could go through the 2024 Hypertrophic Cardiomyopathy Guideline-at-a-Glance which is a five page document which summarises top ten take home messages from the guidelines.

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Digital Consults to Enhance Heart Failure Treatment: The ADMINISTER Trial

Cardiology Update

The primary outcome is the GDMT prescription rate score, with secondary outcomes covering the time to full GDMT optimization, patient and clinician satisfaction, time spent on healthcare, and the Kansas City Cardiomyopathy Questionnaire.

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Aficamten – One More Cardiac Myosin Inhibitor for HOCM

All About Cardiovascular System and Disorders

Mavacamten is now approved for treatment of symptomatic hypertrophic obstructive cardiomyopathy and endorsed by mult-society guidelines. Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy was published in 2023, with 28 patients on aficamten 13 on placebo. J Am Coll Cardiol. 2023 Jan 3;81(1):34-45.

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Left Ventricular Noncompaction

All About Cardiovascular System and Disorders

When non-compaction is associated with left ventricular dysfunction it is called left ventricular non-compaction cardiomyopathy. Blood flow into and out of these recesses can provide a spectacular view on colour Doppler echocardiography, almost looking like flames of fire near the apex, in the apical four chamber view.