Science Daily - Heart Disease

MAY 13, 2024

People with the heart condition obstructive cardiomyopathy were able to use significantly more oxygen while exercising after taking the investigational drug aficamten, according to a new study.

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Exercise Cardiomyopathy 113

American College of Cardiology

NOVEMBER 20, 2024

In this week’s View, Dr. Eagle looks at exercise training in patients with hypertrophic cardiomyopathy (HCM).

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Exercise Cardiomyopathy Article 58

American College of Cardiology

APRIL 8, 2024

Treatment with AT-001, a highly selective aldose reductase inhibitor, had no significant effect on exercise capacity as measured by peak oxygen uptake (VO2) among individuals with diabetic cardiomyopathy (DbCM), according to results from a Late-Breaking Clinical Trial.

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Exercise Cardiomyopathy Diabetes Article 53

Heart BMJ

APRIL 25, 2024

Clinical introduction A patient in his 60s with a history of ischaemic cardiomyopathy and severely reduced left ventricular ejection fraction of 20% presents with worsening dyspnoea on exertion. mL/kg/min) despite maximal effort. The test was stopped due to shortness of breath. Plots 1 and 2 from the CPET are shown in figure 1A and B.

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American Heart News - Heart News

MAY 8, 2024

WASHINGTON and DALLAS (May 8, 2024) – The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM).

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HeartRhythm

OCTOBER 19, 2023

Hypertrophic cardiomyopathy (HCM)-related sudden cardiac death (SCD) rates with contemporary management are low; however, high-intensity exercise can induce fatal arrhythmias in HCM patients. Thus, current guidelines recommend avoiding high-intensity exercise in HCM patients at high risk for SCD1,2.

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Exercise Cardiomyopathy Sudden Cardiac Death Cardiovascular Disease 40

DAIC

JULY 10, 2024

Findings from an observational analysis of ARISE-HF trial participants, newly-published in the Journal of the American College of Cardiology, JACC, shed light on the racial and ethnic disparities in diabetic cardiomyopathy (DbCM), which researchers note may have the potential to inform clinical practice, interventions, and policies.

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Cardiomyopathy Diabetes Health Disparities Exercise 113

Physiologically Speaking

FEBRUARY 28, 2024

These numbers indicate rising participation — an increase in people involved in chronic endurance exercise training for the sake of competition and health. We know exercise, and especially a marathon, stresses the heart. ” Isn’t exercise good for us? ” Isn’t exercise good for us? 

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Exercise Sudden Cardiac Death Physiology Congenital 98

Nature Reviews - Cardiology

MAY 27, 2024

Nature Reviews Cardiology, Published online: 28 May 2024; doi:10.1038/s41569-024-01044-8 Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves quality of life in patients with symptomatic obstructive hypertrophic cardiomyopathy.

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Cardiomyopathy Quality of Life Exercise 64

American College of Cardiology

JULY 2, 2024

What is the effect of AT-001, an aldose reductase inhibitor, on exercise capacity among individuals with diabetic cardiomyopathy (DbCM) with reduced exercise capacity and at high risk for progression to overt heart failure (HF)?

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Cardiomyopathy Diabetes Exercise Heart Failure 53

HeartRhythm

APRIL 30, 2024

Introduction: Pathogenic desmoplakin (DSP) variants are associated with left or biventricular arrhythmogenic cardiomyopathy. Exercise promotes penetrance and sustained ventricular arrhythmias (VA) in classic ARVC. It is unknown if exercise affects risk in DSP variant carriers.

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Nature Reviews - Cardiology

APRIL 22, 2024

Nature Reviews Cardiology, Published online: 23 April 2024; doi:10.1038/s41569-024-01032-y According to data from the IMPROVE-HCM trial, ninerafaxstat is well tolerated by patients with symptomatic non-obstructive hypertrophic cardiomyopathy and improves exercise performance among those who are most symptomatically limited.

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Cardiomyopathy Exercise 59

Open Heart

NOVEMBER 27, 2024

Introduction Atrial fibrillation (AF)-induced cardiomyopathy (AIC) is retrospectively defined after normalisation of left ventricular ejection fraction (LVEF) in sinus rhythm. It is unclear why some patients develop AIC. Hypothesis Patients with AIC have a subtle cardiomyopathic process that precedes their AF-mediated LVEF reduction.

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Atrial Fibrillation Cardiomyopathy Ablation Cardiac Function 52

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

Hypertrophic cardiomyopathy is the most common genetic cardiac disorder and is defined by the presence of left ventricular (LV) hypertrophy in the absence of a condition capable of producing such a magnitude of hypertrophy. Over the past decade, guidelines on the screening, diagnostic, and management protocols of pediatric primary (i.e.,

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Pediatrics Cardiomyopathy Heart Failure Exercise 87

HCPLive

MAY 9, 2024

Compass Pathways reports positive results for psilocybin in PTSD treatment, showing safety and symptom improvement in an open-label phase 2 study.

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Exercise Cardiomyopathy 72

DAIC

APRIL 9, 2024

Maron, MD “Our findings provide enthusiasm that a novel drug therapy with ninerafaxstat may provide nonobstructive HCM patients an opportunity to achieve a better quality of life by decreasing symptom burden and improving exercise capacity,” said Martin S. For more information on hypertrophic cardiomyopathy, visit CardioSmart.org/HCM.

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Cardiomyopathy Quality of Life Preserved Ejection Fraction Chest Pain 52

NEJM Journal Watch - Cardiology

MAY 11, 2024

New recommendations include exercise prescription and treatment with cardiac myosin inhibitors.

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HeartRhythm

APRIL 30, 2024

Hypertrophic cardiomyopathy (HCM) is associated with a predisposition to lethal ventricular arrhythmias. LGE scar burden on MRI is thought to contribute to this risk, but its impact on electrophysiological substrate is not well understood.

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Cardiomyopathy Electrophysiology Exercise Arrhythmia 40

DAIC

MAY 9, 2024

The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). Ommen, MD, FACC , medical director of the Mayo Hypertrophic Cardiomyopathy Clinic and chair of the guideline writing committee.

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Cardiomyopathy Pediatrics Quality of Life Sudden Cardiac Death 52

HeartRhythm

APRIL 30, 2024

Autonomic remodeling is known to occur in premature ventricular contraction-induced cardiomyopathy (PVC-CM). However, the functional significance of this finding remains unclear.

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Cardiomyopathy Exercise 40

The American Journal of Cardiology

SEPTEMBER 21, 2024

Publication date: Available online 20 September 2024 Source: The American Journal of Cardiology Author(s): Agostina M. Fava, Zoran B Popovic, Alaa Alashi, Maran Thamilarasan, Bo Xu, Milind Y.

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Exercise Cardiomyopathy 40

Med Page Today

MAY 13, 2024

(MedPage Today) -- The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean change in the peak oxygen uptake.

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Exercise Cardiomyopathy 52

NEJM Journal Watch - Cardiology

APRIL 30, 2024

The highly selective aldose reductase inhibitor AT-001 did not improve exercise capacity in a randomized trial.

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Cardiomyopathy Diabetes Exercise Outcomes 81

Circulation: Genomic and Precision Medicine

NOVEMBER 28, 2023

Background:Limiting high-intensity exercise is recommended for patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) due to its association with penetrance, arrhythmias, and structural progression. Guidelines recommend shared decision-making (SDM) for exercise level, but there is little evidence regarding its impact.

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Exercise Cardiomyopathy Arrhythmia Circulation 40

European Journal of Heart Failure

SEPTEMBER 26, 2023

Exercise training in patients with advanced heart failure and left ventricular assist device (Ex-VAD) trial. 6MWT, 6-min walk test; KCCQ, Kansas City Cardiomyopathy Questionnaire physical domain score; peakVO 2 , peak oxygen consumption; RCT, randomized controlled trial. m (95% CI 16.9, p  = 0.0124), both after 12 weeks. m (95% CI 16.9,

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Exercise Heart Failure Quality of Life Cardiomyopathy 40

Circulation

OCTOBER 19, 2023

BACKGROUND:The consequences of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals remain unclear. Low PVC counts during exercise and recovery were both associated with MI/HF/LTVA risk, independently of clinical factors: adjusted hazard ratio (HR), 1.2 (1–5 years; 51.1% years; 51.1%

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Exercise Myocardial Infarction Heart Failure Cardiomyopathy 40

All About Cardiovascular System and Disorders

APRIL 30, 2024

Hypertrophic cardiomyopathy is a genetic disorder with a guarded prognosis which occurs in about 1:500 individuals. The most common symptom of hypertrophic cardiomyopathy is dyspnoea which occurs in 90% of cases and is due to elevated left ventricular diastolic pressures as a consequence of the diastolic dysfunction.

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Cardiomyopathy Bicuspid/Mitral Document Arrhythmia 40

Open Heart

JUNE 9, 2022

Background This review aimed to compare the relative effectiveness of different exercise-based cardiac rehabilitation (ExCR) delivery modes (centre-based, home-based, hybrid and technology-enabled ExCR) on key heart failure (HF) outcomes: exercise capacity, health-related quality of life (HRQoL), HF-related hospitalisation and HF-related mortality.

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Quality of Life Cardiac Rehabilitation Exercise Heart Failure 52

NEJM Journal Watch - Cardiology

JUNE 3, 2024

In a manufacturer-funded trial, aficamten improved exercise performance compared with placebo in patients with symptomatic obstructive HCM.

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Cardiomyopathy Exercise 40

European Journal of Heart Failure

DECEMBER 22, 2023

Abstract Background and aims In the EXPLORER-HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients.

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Cardiomyopathy Pharmacology Atrial Fibrillation Outpatient 40

EMS 12-Lead

MAY 20, 2022

She reports a known history of Hypertrophic Cardiomyopathy (HCM) with left ventricular outflow tract obstruction and is on daily beta blocker therapy. Furthermore, she denies any hydration since conclusion of exercise. Diagnosis and management of hypertrophic cardiomyopathy: Expert analysis. References Naidu, S. Tower-Rader, A.

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Cardiomyopathy Ischemia STEMI Coronary Angiogram 52

American College of Cardiology

SEPTEMBER 30, 2024

Treatment with aficamten in patients with obstructive hypertrophic cardiomyopathy (oHCM) was associated with broad clinical efficacy across multiple outcome domains, including rapid and sustained decreases in outflow gradients, meaningful improvements in functional class and quality of life, enhanced exercise capacity, and significant reductions in (..)

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Quality of Life Exercise Cardiomyopathy Outcomes 40

Circulation: Heart Failure

DECEMBER 18, 2023

RESULTS:In hypertrophic cardiomyopathy, RT (estimated marginal mean [95% CI]) was 3.4 (0.4–6.4) mm Hg with exercise (P<0.001). RESULTS:In hypertrophic cardiomyopathy, RT (estimated marginal mean [95% CI]) was 3.4 (0.4–6.4) mm Hg with exercise (P<0.001). mm Hg, increasing to 18.5 mm Hg, increasing to 18.5

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Preserved Ejection Fraction Exercise Cardiomyopathy Heart Failure 40

Heart BMJ

MAY 10, 2024

Objective The objective is to evaluate the 5-year follow-up results of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for hypertrophic obstructive cardiomyopathy (HOCM), including clinical status, electrocardiographic and echocardiographic characteristics. mm Hg, p<0.001; post exercise: from 130.5

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All About Cardiovascular System and Disorders

MAY 2, 2024

During aerobic exercise which is isotonic, the heart rate and stroke volume increases. Isometric exercise or weight training on the other hand causes only slight increase in cardiac output due to increase in heart rate. Effect of exercise on right ventricle. J point elevation and early repolarization pattern has been reported.

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Exercise Cardiomyopathy Blood Pressure Physiology 40

DAIC

APRIL 9, 2024

Decline in exercise ability is a hallmark of progression to overt heart failure. The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy.

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Heart Failure Diabetes Cardiomyopathy Exercise 52

DAIC

MAY 6, 2024

Patients who transitioned to the oral daily formulation after a lengthy treatment with the weekly IV formulation improved further in this assessment of exercise tolerance, which is the primary endpoint of the ongoing Phase 3 LEVEL study. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,

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