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Systemic Circulation in Advanced Heart Failure and Cardiogenic Shock: State-of-the-Art Review

Circulation: Heart Failure

The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. Circulation: Heart Failure, Ahead of Print. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle.

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Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development

Open Heart

Background The relationship between speckle tracking assessed global longitudinal strain (GLS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops is poorly elucidated.

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Abstract 4143363: Direct Left Ventricular Unloading Vs Counter Pulsation Support Exhibits Differential miRNA Expression In The Left Ventricle Of Cardiogenic Shock Patients

Circulation

Background:Various temporary mechanical circulatory support device (t-MCS) options are available for supporting patients in cardiogenic shock. While each device has a different physiological impact on the heart, limited studies compare genetic changes in the heart t-MCS. and 4 bridged with IABP.

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Advanced hemodynamics for prognostication in heart failure: the pursuit of the patient-specific tipping point

Frontiers in Cardiovascular Medicine

Methods Here, a mathematical and physiological framework to define the patient-specific tipping point of myocardial energetics is defined. A novel hemodynamic parameter known as the myocardial performance score (MPS), a marker of power and efficiency, is introduced that allows for the objective assessment of the physiological tipping point.

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Magenta Medical, Developer of World’s Smallest Heart Pump, Closes $105M Financing Round

DAIC

FDA for two clinical indications: high-risk percutaneous coronary intervention (HR-PCI) and cardiogenic shock (CS). Because of these potential advantages, Magenta's Elevate System was granted Breakthrough Device Designation by the U.S. Magenta completed a U.S. Early Feasibility Study with the HR-PCI indication in 2023.

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Abstract 4143844: Multidisciplinary management of a pregnant patient with advanced systolic heart failure

Circulation

However, stabilization was expected to be temporary due to ongoing physiologic changes of pregnancy. After discharge, she was scheduled for a 2-week postpartum visit including echocardiogram, EKG, and NT-proBNP.Discussion:Given the patient's acute decompensation and fluid overload, medical optimization was essential prior to delivery.

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Diffuse Subendocardial Ischemia on the ECG. Left main? 3-vessel disease? No!

Dr. Smith's ECG Blog

Authors' commentary: Cardiogenic shock in the setting of severe aortic stenosis. This patient’s severe aortic stenosis (AS) and associated severe cardiogenic shock likely created the ECG pattern, resulting in a very difficult challenge for our inpatient team. If you can use Doppler, then you can diagnose it.